The investigators conduct a multicenter randomized controlled study to evaluate the diagnostic value and safety of 22G Adapt Aspiration puncture needle for histopathology of solid lesions.

Start Date01 Sep 2024

Sponsor / Collaborator

Huazhong University of Science & Technology

[+5]

ChiCTR2400083377 / SuspendedNot Applicable

Study on the safety and effectiveness of paravertebral nerve block in thoracoscopic mediastinal tumor surgery in children and the quality of postoperative recovery

Start Date23 Apr 2024

Sponsor / Collaborator-

ChiCTR2300077494 / RecruitingNot ApplicableIIT

Analysis of surgical strategy for superior vena cava reconstruction

Start Date12 Nov 2023

Sponsor / Collaborator

Shanghai Chest Hospital

100 Clinical Results associated with Mediastinal Cancer

100 Translational Medicine associated with Mediastinal Cancer

0 Patents (Medical) associated with Mediastinal Cancer

2,966

Literatures (Medical) associated with Mediastinal Cancer

01 Nov 2024·Journal of Thoracic Imaging

Mesothelioma Mimicking a Mediastinal Tumor in the Prevascular Compartment

Article

Author: Nomura, Masahiko ; Hattori, Hidekazu ; Horiguchi, Tomoya ; Ueda, Takahiro ; Nagata, Hiroyuki ; Hoshikawa, Yasushi ; Ozawa, Yoshiyuki ; Matsuda, Yasushi ; Takahashi, Tomoki ; Tsukamoto, Tetsuya ; Ohno, Yoshiharu ; Imaizumi, Kazuyoshi ; Kondo-Kawabe, Yuka

01 Nov 2024·Radiotherapy and Oncology

Impact of mediastinal tumor burden and lymphatic spread in locally advanced non-small-cell lung cancer: A secondary analysis of the multicenter randomized PET-Plan trial

Article

Author: Grosu, Anca-Ligia ; Brose, Alexander ; Gkika, Eleni ; Schimek-Jasch, Tanja ; Sahlmann, Jörg ; Adebahr, Sonja ; Nestle, Ursula ; Hecht, Markus ; Barth, Simeon Ari ; Stefaan Dejonckheere, Cas ; König, Jochem ; Miederer, Matthias ; Binder, Harald ; Dejonckheere, Cas Stefaan ; Ari Barth, Simeon ; Rimner, Andreas

PURPOSEThe aim of this secondary analysis of the prospective randomized phase 2 PET-Plan trial (ARO-2009-09; NCT00697333) was to evaluate the impact of mediastinal tumor burden and lymphatic spread in patients with locally advanced non-small-cell lung cancer (NSCLC).METHODSAll patients treated per protocol (n = 172) were included. Patients received isotoxically dose-escalated chemoradiotherapy up to a total dose of 60-74 Gy in 30-37 fractions, aiming as high as possible while adhering to normal tissue constraints. Radiation treatment (RT) planning was based on an ¹⁸F-FDG PET/CT targeting all lymph node (LN) stations containing CT positive LNs (i.e. short axis diameter > 10 mm), even if PET-negative (arm A) or targeting only LN stations containing PET-positive nodes (arm B). LN stations were classified into echelon 1 (ipsilateral hilum), 2 (ipsilateral station 4 and 7), and 3 (rest of the mediastinum, contralateral hilum). The endpoints were overall survival (OS), progression-free survival (PFS), and freedom from local progression (FFLP).RESULTSThe median follow-up time (95 % confidence interval [CI]) was 41.1 (33.8 - 50.4) months. Patients with a high absolute number of PET-positive LN stations had worse OS (hazard ratio [HR] = 1.09; 95 % CI 0.99 - 1.18; p = 0.05) and PFS (HR = 1.12; 95 % CI 1.04 - 1.20; p = 0.003), irrespective of treatment arm allocation. The prescribed RT dose to the LNs did not correlate with any of the endpoints when considering all patients. However, in patients in arm B (i.e., PET-based selective nodal irradiation), prescribed RT dose to each LN station correlated significantly with FFLP (HR=0.45; 95 % CI 0.24-0.85; p = 0.01). Furthermore, patients with involvement of echelon 3 LN stations had worse PFS (HR = 2.22; 95 % CI 1.16-4.28; p = 0.02), also irrespective of allocation.CONCLUSIONMediastinal tumor burden and lymphatic involvement patterns influence outcome in patients treated with definitive chemoradiotherapy for locally advanced NSCLC. Higher dose to LNs did not improve OS, but did improve FFLP in patients treated with PET-based dose-escalated RT.

01 Oct 2024·Radiology Case Reports

Unusual presentation of giant mature mediastinal teratoma in a young child: A case report

Article

Author: Dalero, Omar ; El Madi, Aziz ; Hassani, Zakarya Alami ; Andaloussi, Saad

Mature mediastinal teratoma is a rare benign tumor in children. Few cases have been reported in the literature. Moreover, this tumor is often characterized by slow growth, reaching a large volume and frequently causing nonspecific symptoms, making its diagnosis more difficult. It raises the question of differential diagnosis with malignant mediastinal tumors in pediatric patients, requiring histological confirmation by biopsy or excision. The purpose of this article is to report an atypical clinical finding characterized by spinal deformity, and to contribute to medical knowledge concerning this uncommon pediatric tumor.

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