The investigators conduct a multicenter randomized controlled study to evaluate the diagnostic value and safety of 22G Adapt Aspiration puncture needle for histopathology of solid lesions.

Start Date01 Sep 2024

Sponsor / Collaborator

Huazhong University of Science & Technology

[+5]

ChiCTR2400092218

/ RecruitingNot ApplicableIIT

Surgical Treatment of Invasive Mediastinal Tumors

Start Date01 Jul 2024

Sponsor / Collaborator-

100 Clinical Results associated with Mediastinal Cancer

100 Translational Medicine associated with Mediastinal Cancer

0 Patents (Medical) associated with Mediastinal Cancer

3,311

Literatures (Medical) associated with Mediastinal Cancer

31 Dec 2025·Annals of Medicine

An overview of downhill esophageal varices: a challenge for medical practice

Review

Author: Wang, Donghong ; Ma, Zhibin

OBJECTIVESUnlike the commonly seen uphill esophageal varices in clinical practice, downhill esophageal varices are caused by obstruction of the superior vena cava and azygous venous system. The predominant causes of downhill esophageal varices are hemodialysis in end-stage renal disease patients and mediastinal malignancies. The cornerstone of the treatment for downhill esophageal varices is to address the underlying primary causes. Without this, patients may suffer from recurrent bleeding, and the bleeding can be fatal.METHODSThis review is primarily summarized through previous case reports. Meanwhile, it emphasizes the significance of case reports.RESULTSClinicians should be conscious that esophageal varices are not necessarily caused by liver cirrhosis or non-cirrhotic portal hypertension.CONCLUSIONSSpecifically, when varices are only observed in the upper and middle esophagus, and the patient presents with evidence of superior vena cava obstruction, clinicians should be particularly vigilant for downhill esophageal varices. Moreover, a thorough investigation and definitive treatment of the underlying primary causes should be implemented.

01 May 2025·Journal of Pediatric Surgery

Comparison of Video-assisted Surgery and Open Surgery for Mediastinal Tumor Resection in Pediatric Population: A Systematic Review and Meta-analysis

Review

Author: Salvador, Isabella Cabianca Moriguchi Caetano ; Noleto da Nobrega Oliveira, Rachid Eduardo ; Passos, Felipe S ; Camarotti, Maria Tereza ; Fernandes Torres, Lucas Antônio

BACKGROUNDThe surgical management of mediastinal tumors in pediatric patients presents unique challenges due to the anatomical and physiological characteristics of this population. Video-assisted thoracoscopic surgery (VATS) has gained prominence as a minimally invasive alternative to open thoracotomy and median sternotomy (OT), offering potential benefits such as reduced postoperative pain and shorter recovery times. However, the relative effectiveness and safety of VATS compared to OT remain under debate.METHODSWe conducted a systematic review and meta-analysis following PRISMA guidelines, including retrospective studies comparing VATS and OT in pediatric patients undergoing mediastinal tumor resection. Statistical analyses were performed using random effects models, and heterogeneity was assessed with Cochran's Q-test and I² statistics.RESULTSSeven studies comprising 333 pediatric patients (41.7 % undergoing VATS and 58.2 % OT) met the inclusion criteria. VATS was associated with significantly reduced LOS (MD -3.23 days; 95 % CI: -5.57 to -0.89; p < 0.01), complications (OR 0.40; 95 % CI: 0.19 to 0.82; p = 0.01), intraoperative blood loss (MD -22.40 mL; 95 % CI: -38.59 to -7.22; p < 0.01), and intraoperative blood transfusion (OR 0.08; 95 % CI: 0.03 to 0.21; p < 0.01). No significant differences were observed between VATS and OT for recurrence (OR 0.37; 95 % CI: 0.08 to 1.75; p = 0.21) or mortality (OR 0.25; 95 % CI: 0.06 to 1.04; p = 0.06).CONCLUSIONThe results of this meta-analysis, including 333 pediatric patients, suggest that VATS is associated with significant reductions in LOS, complication rates, intraoperative blood loss, and transfusion requirements compared to OT, without compromising oncological outcomes. VATS can be performed safely with a low LOS, but more complex tumors will still require open surgery.TRIAL REGISTRYInternational Prospective Register of Systematic Reviews; Nº: CRD42025634968; URL: https://www.crd.york.ac.uk/prospero/.

01 May 2025·International Journal of Surgery Case Reports

Giant anterior mediastinal thymolipoma: A rare case of thoracoscopic resection and surgical management challenges

Article

Author: Bessrour, Habib ; Ragmoun, Wafa ; Tlili, Karima ; Hachicha, Saber ; Messaoudi, Houssem ; Lajmi, Mokhles

INTRODUCTIONThymolipoma is a rare benign anterior mediastinal tumor composed of thymic and adipose tissues. Early diagnosis and accurate surgical management are crucial to prevent misdiagnosis and optimize patient outcomes.CASE PRESENTATIONA 17-year-old male with no significant medical history presented to our thoracic surgery department with exertional dyspnea and a sensation of chest tightness. Given the worsening symptoms, a chest computed tomography (CT) scan was performed, revealing a well-circumscribed anterior mediastinal mass in the right paracardiac region, predominantly composed of fatty tissue. The patient underwent right thoracoscopic surgery, during which the tumor was successfully resected. The postoperative course was uneventful. Histopathological examination confirmed the diagnosis of a thymolipoma.DISCUSSIONThymolipomas are rare benign tumors composed of mature adipose tissue and thymic tissue, typically located in the anterior mediastinum. They account for less than 9 % of all thymic tumors and are often discovered incidentally. Patients with thymolipomas may present with nonspecific symptoms, such as dyspnea, chest pain, or recurrent respiratory infections, depending on the size and compressive effects of the tumor. Imaging plays a crucial role in identifying thymolipomas, with CT scan often showing a well-encapsulated mass with fat and soft tissue components. Complete surgical resection remains the cornerstone of treatment, ensuring both accurate diagnosis and symptomatic relief.CONCLUSIONThis case underlines the exceptional presentation of a thymolipoma, emphasizing its rarity and the critical role of surgical management in achieving optimal outcomes. Early recognition and intervention are crucial, especially for large or symptomatic lesions.

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