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Last update 23 Jan 2025

Mild depression

Last update 23 Jan 2025

Basic Info

Synonyms

Depression, mild, Mild depression, Mild depression (diagnosis)

+ [3]

Introduction-

Drugs associated with Mild depression

Psilocybin

Target

5-HT1A receptor x 5-HT2A receptor x 5-HT2C receptor x 5-HT6 receptor

Mechanism

5-HT1A receptor antagonists [+3]

Active Org.

Compass Pathways Plc [+31]

Originator Org.-

Active Indication

Depressive Disorder, Major [+40]

Inactive Indication

Major depressive disorder, moderate (MDD) [+3]

Drug Highest PhasePhase 3

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Yushuda Tablets

Target-

Mechanism-

Active Org.

Institute Of Traditional Chinese Medicine Chinese Academy Of Traditional Chinese Medicine [+1]

Originator Org.

Institute Of Traditional Chinese Medicine Chinese Academy Of Traditional Chinese Medicine

Active Indication

Mild depression [+1]

Inactive Indication-

Drug Highest PhasePhase 3

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Chaigui Granules

Target-

Mechanism-

Active Org.

Shanxi University

Originator Org.

Shanxi University

Active Indication

Mild depression [+1]

Inactive Indication-

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

136

Clinical Trials associated with Mild depression

DRKS00031707

/ SuspendedNot ApplicableIIT

iFightDepression App Evaluation of use Evaluation of incidental usage data for further improvement of the intervention

Start Date01 Jun 2025

Sponsor / Collaborator-

NCT06336538

/ Not yet recruitingNot ApplicableIIT

Community Engagement in the Development of an Abbreviated Mindfulness-Based Cognitive Therapy Intervention for Depression in Older African American/Black Breast Cancer Survivors (Community Minds)

The purpose of this research study is to develop and test an intervention designed to improve mood and reduce symptoms of depression.

Start Date01 May 2025

Sponsor / Collaborator

The Case Comprehensive Cancer Center

NCT06751784

/ Not yet recruitingPhase 2

Randomized Placebo-controlled Phase II Cross-over Study on the Influence of Fampridine on Working Memory in Mild Depression

Cognitive deficits, including working memory deficits, are often present in depression and there are currently no effective pharmacological treatments targeting working memory deficits. Papassotiropoulos et al. (2024) has recently demonstrated that fampridine, a potassium channel blocker, can enhance working memory in healthy individuals with lower baseline performance, suggesting it may hold potential for addressing cognitive deficits in clinical populations. The primary aim of this study is to evaluate whether fampridine improves working memory performance in mild depression

Start Date01 Apr 2025

Sponsor / Collaborator

University of Basel

[+1]

100 Clinical Results associated with Mild depression

100 Translational Medicine associated with Mild depression

0 Patents (Medical) associated with Mild depression

Literatures (Medical) associated with Mild depression

01 Feb 2025·Psychiatry Research

Unipolar mania over the course of a 15-year follow-up study

Article

Author: Jiang, De-Gua ; Shi, Hua-Meng

OBJECTIVEA proportion of patients with bipolar disorder (BD) manifests with only Unipolar mania (UM). We conducted a follow-up study of patients diagnosed with Unipolar mania and compared them as a group if they had a mild depressive episode with those who did not.METHOD248 subjects were prospectively followed-up to 15 years. During the 15-year follow-up study, Pure mania was defined as patients who did not experience mild depressive episodes(203) and Mania with mild depression was defined as patients who did experience mild depressive episodes(45). Then, we compare characterization of clinical features between Pure mania (PM) and Mania with mild depression (MMD).RESULTSCompared with the Mania with mild depression group, the Pure mania group had more psychotic symptoms, fewer suicidal behaviors, a higher proportion of morningness chronotype, better sleep quality, higher extraversion, lower neuroticism, and less harm avoidance personality traits. Substantially different lifetime comorbidity patterns were observed between the two groups.CONCLUSIONPatients with Pure mania exhibited distinct clinical and psychosocial features compared with patients with the Mania with mild depression. Further studies are warranted to investigate the underlying mechanisms for diverse presentations in subgroups of BDs.LIMITATIONSThese results apply to a relatively short outcome period, and the sample size is relatively small.

22 Dec 2024·Neuro endocrinology letters

First-episode mild depression in young adults is a pre-proatherogenic condition even in the absence of subclinical metabolic syndrome: lowered lecithin-cholesterol acyltransferase as a key factor.

Article

Author: Vasupanrajit, Asara ; Tunvirachaisakul, Chavit ; Jirakran, Ketsupar ; Maes, Michael ; Zhou, Bo ; Almulla, Abbas F

BACKGROUNDMajor depression is classified into distinct subtypes: simple (SDMD) and major dysmood disorder (MDMD). MDMD patients exhibit elevated atherogenicity and decreased reverse cholesterol transport (RCT). However, comprehensive data regarding lipid metabolism is absent in first episode (FE)-SDMD.AIMSIn this case-control study, plasma lipid levels, lecithin-cholesterol acyltransferase (LCAT), free cholesterol, apolipoprotein (Apo)A1, ApoB, and ApoE are compared between academic students with first episode SDMD (FE-SDMD) (n = 44) or SDMD (n = 64) and control students (n = 44), after excluding those with metabolic syndrome (MetS).RESULTSLCAT is decreased, and free cholesterol and ApoE increased in subjects with SDMD and FE-SDMD as compared with controls. There were no significant alterations in high-density lipoprotein cholesterol (HDLc), ApoA1, RCT, ApoB and triglycerides in SDMD. LCAT, free cholesterol and atherogenicity indices are significantly associated with suicidal behaviors and the SDMD phenome. The effects of LCAT on those phenome features is completely mediated by free cholesterol and brooding. SDMD and FE-SDMD patients without signs of subclinical MetS show lowered LCAT and increased free cholesterol as compared with normal controls. There are significant interactions between the SDMD and FE-SDMD diagnosis and subclinical MetS, which result in decreased HDLc and RCT, and an increased ApoB/ApoA ratio.DISCUSSIONFE-SDMD and SDMD are pre-proatherogenic states, because of decreased LCAT, and increased free cholesterol and ApoE, and their intersections with subclinical MetS. These aberrations may drive atherogenicity, and activation of peripheral and central oxidative, neuro-immune, and degenerative pathways. Individuals with FE-SDMD should be screened and treated for increased atherogenicity risk by measuring free cholesterol and ApoE.

01 Aug 2024·Neuroscience

Increased malondialdehyde and nitric oxide formation, lowered total radical trapping capacity coupled with psychological stressors are strongly associated with the phenome of first-episode mild depression in undergraduate students

Article

Author: Maes, Michael ; Tunvirachaisakul, Chavit ; Almulla, Abbas F ; Michelin, Ana Paula ; Brinholi, Francis F ; Matsumoto, Andressa K ; Barbosa, Décio S ; Vasupanrajit, Asara ; Semeão, Laura de O

Undergraduate students are frequently afflicted by major depressive disorder (MDD). Oxidative and nitrosative stress (O&NS) has been implicated in the pathophysiology of MDD. There is no information regarding whether mild outpatient MDD (SDMD) and first episode SDMD (FE-SDMD) are accompanied by O&NS. The current study compared lipid hydroperoxides (LOOH), malondialdehyde (MDA), advanced protein oxidation products, nitric oxide metabolites (NOx), thiol groups, plasma total antioxidant potential (TRAP), and paraoxonase 1 activities among SDMD and FE-SDMD patients versus healthy controls. We found that SDMD and FE-SDMD exhibit elevated MDA and NOx, and decreased TRAP and LOOH as compared with controls. There was a significant and positive correlation between O&NS biomarkers and adverse childhood experiences (ACEs), and negative life events (NLEs). O&NS pathways, NLEs and ACEs accounted for 51.7 % of the variance in the phenome of depression, and O&NS and NLS explained 42.9 % of the variance in brooding. Overall, these results indicate that SDMD and FE-SDMD are characterized by reduced total antioxidant defenses and increased aldehyde and NOx production. The combined effects of oxidative and psychological stressors are substantially associated with the manifestation of SDMD.

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Mild depression

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