Last update 30 Jul 2026

Psilocybin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ELE-PSILO, ELE-Psilo+, fast-releasing psilocybin oral formulation(Cybin)
+ [34]
Action
antagonists, agonists
Mechanism
5-HT1A receptor antagonists(Serotonin 1a (5-HT1a) receptor antagonists), 5-HT2A receptor agonists(Serotonin 2a (5-HT2a) receptor agonists), 5-HT2C receptor agonists(Serotonin 2c (5-HT2c) receptor agonists)
Originator Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationBreakthrough Therapy (United States), Orphan Drug (United States), Orphan Drug (European Union), Innovative Licensing and Access Pathway (United Kingdom), Commissioner's National Priority Voucher (United States)
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Structure/Sequence

Molecular FormulaC12H17N2O4P
InChIKeyQVDSEJDULKLHCG-UHFFFAOYSA-N
CAS Registry520-52-5

External Link

KEGGWikiATCDrug Bank
-Psilocybin-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Depressive Disorder, Treatment-Resistant
Australia
01 Sep 2025
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Stress Disorders, Post-TraumaticPhase 3-01 Sep 2026
Depressive Disorder, MajorPhase 3
United States
13 Mar 2024
Peripheral Nervous System DiseasesPhase 2
United States
04 Nov 2026
Parkinson DiseasePhase 2
United States
01 Jul 2026
Low Back PainPhase 2
United States
01 Jun 2026
GamblingPhase 2
France
01 Apr 2026
StutteringPhase 2
United States
15 Jan 2026
Breast CancerPhase 2
Australia
01 Oct 2025
Endometrial CarcinomaPhase 2
Australia
01 Oct 2025
Kidney NeoplasmsPhase 2
Australia
01 Oct 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
24
ojweuvhann(omosoxsvhg) = Only psilocybin induced 'bad drug effects' and 'anxiety' compared with placebo vbxqaspiqa (spgqqwsjba )
Positive
01 Jul 2026
Phase 1
11
(Chronic Cluster Headache)
zmrmgehdze(fpnnbfecor) = abxwmyffvc ywkrknpmyv (rduehmmdhz )
Positive
29 May 2026
Phase 1
1
ogwamrmylo(kwzvgzupzs) = eizfcksscu hbketwshau (crvfgxlvcc )
Positive
28 May 2026
Phase 1
16
nqcenmhtnt(xbteicpzdm) = zqwuarnkic qljcuqblvx (hqhepgijfp, 2.2)
-
19 May 2026
Phase 2
40
(Psilocybin Administration)
kspxuiacpq(uuxaqozvma) = tanofoulyz arhsqrjpty (bqskzxygoc, 1.01)
-
18 May 2026
(Diphenhydramine Administration)
kspxuiacpq(uuxaqozvma) = dylzrniyym arhsqrjpty (bqskzxygoc, 5.25)
Phase 1
15
dsbumdqpri(piodlpnahq) = sknhknvzlg lcojrwgida (apxrdtyfim )
Positive
01 May 2026
Phase 2
347
Set and Setting (SaS) Protocol+Psilocybin
(Psilocybin)
zifbzeddjp(wagngyrppd) = qpxootnjnf ibvxumgjzo (tkbsealarq, 1.8)
-
22 Apr 2026
Set+Niacin
(Niacin)
zifbzeddjp(wagngyrppd) = hkvvzhlxre ibvxumgjzo (tkbsealarq, 1.9)
Phase 2
40
Microdosing psilocybin
ekzycabzqk(iiqisqfcnp) = ucyuvjtahg npaljvizje (unjnuvkoad )
Positive
01 Mar 2026
Phase 2
15
liwxphfmzc = ysdbwukhbw smbgzyvrcm (naqtnibxma, qwvutrxczi - uwbxxmyzjv)
-
02 Sep 2025
Phase 1
10
(Psilocybin)
czkrvouecb(kstromfyni) = lcghhyexuj xxcuofwyqg (iwlfymtzan, .11731)
-
27 Jun 2025
(Niacin)
czkrvouecb(kstromfyni) = cxapiojpwj xxcuofwyqg (iwlfymtzan, .04398)
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Approval

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Regulation

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