Last update 01 Nov 2024

Laryngostenosis

Last update 01 Nov 2024

Basic Info

Synonyms

LARYNGEAL STENOSIS, Laryngeal Stenoses, Laryngeal Stenosis

+ [29]

Introduction

Developmental or acquired stricture or narrowing of the LARYNX. Symptoms of respiratory difficulty depend on the degree of laryngeal narrowing.

Drugs associated with Laryngostenosis

Olfactory mucosa-derived mesenchymal stem cells(Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus)

Target-

Mechanism

Stem cell replacements

Active Org.

Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus

Originator Org.

Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus

Active Indication

Laryngostenosis [+1]

Inactive Indication-

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Laryngostenosis

CTRI/2024/08/071943 / Not yet recruitingNot Applicable

To evaluate poor prognostic factors in laryngotracheal stenosis: An Ambispective study. - NIL

Start Date13 Aug 2024

Sponsor / Collaborator-

NCT03269396 / Enrolling by invitationNot ApplicableIIT

A Prospective Nonrandomized Study of Laryngeal Allograft Transplantation Clinical Investigation

The purpose of this proposed study is to obtain safety and efficacy data on human laryngeal allograft transplantation in an effort to safely use these procedures as a viable reconstructive option for patients with severe laryngeal or laryngotracheal incompetence.

Start Date19 May 2023

Sponsor / Collaborator

Mayo Clinic

NCT05688488 / RecruitingPhase 1/2IIT

Clinical Study of Curcumin in Preventing Postoperative Adhesion of Bilateral Vocal Cords

To provide a novel therapy idea and method to solve the clinical problem of postoperative adhesion of bilateral vocal cords, patients enrolled in this study will be applied with curcumin on both wound sites of bilateral vocal cords after the surgery on the bilateral vocal cord endoscopically.

Start Date05 May 2023

Sponsor / Collaborator

Fudan University Affiliated Eye & Ent Hospital

100 Clinical Results associated with Laryngostenosis

100 Translational Medicine associated with Laryngostenosis

0 Patents (Medical) associated with Laryngostenosis

899

Literatures (Medical) associated with Laryngostenosis

19 Sep 2024·Ear, nose, & throat journal

A Modified Epiglottis-Tongue Root Flap for Postoperative Laryngeal Stenosis in a Cancer Patient with a History of Radiotherapy.

Article

Author: Fan, Lixiao ; Liu, Jun ; Yang, Xin ; Wang, Dejuan ; Chen, Fei ; Zhao, Pengwei ; Jiang, Zheng

Introduction: Cricohyoidoepiglottopexy (CHEP) has emerged as a promising surgical technique for treating laryngeal stenosis, offering a low rate of restenosis and a high rate of successful decannulation. However, postoperative radiation therapy can complicate open surgery for some patients due to radiation-induced cellular and tissue damage. This damage can make adequate exposure or mobilization of the larynx challenging. Case Summary: A 71-year-old male, who had undergone a partial laryngectomy 3 years prior, developed laryngeal stenosis and difficulty plugging after 35 rounds of radiotherapy. Initially, CHEP was planned, but intraoperatively, it was found that traditional CHEP would result in excessive anastomotic tension. To prevent complications, we designed an epiglottis-tongue root flap for laryngeal function reconstruction. The patient experienced no restenosis and was successfully extubated. Discussion: By separating the preepiglottal space and mobilizing the base of the tongue to construct the epiglottis-tongue root flap, modified CHEP can achieve laryngeal function reconstruction in patients postradiotherapy. It is essential to conduct a comprehensive evaluation of the patient's overall condition, degree of stenosis, tongue-to-tongue root status, and cervical tissue adhesion before surgery.

19 Sep 2024·The Laryngoscope

JAK-inhibitor Tofacitinib in Severe Laryngeal Sarcoidosis: A Case Report.

Article

Author: Stoenchev, Kostadin ; Al Yaghchi, Chadwan ; Kouranos, Vasileios ; Demir, Meryem ; Morar, Nilesh ; Durham, Stephen R ; Sandhu, Guri S ; Scadding, Guy W ; Saleh, Hesham

Sarcoidosis is an inflammatory, non-caseating granulomatous multisystem disease associated with JAK-STAT (Janus kinases-signal transducer and activator of transcription proteins) pathway activation. We present a patient with severe multi-systemic sarcoidosis who showed marked improvement with tofacitinib with regards to pulmonary, cutaneous, nasal and laryngeal disease. Tofacitinib prevented critical laryngeal stenosis from progressing to tracheostomy, induced regression of cutaneous lesions and improved pulmonary function in this steroid-resistant and immunosuppressive intolerant case. This case report supports further the role of JAK-inhibitors in the treatment of systemic sarcoidosis. Laryngoscope, 2024.

01 Sep 2024·Iranian journal of otorhinolaryngology

Junctional Epidermolysis Bullosa Associated Laryngeal Stenosis: A Case Report and Review of Literature.

Article

Author: Al Harrasi, Ziyad ; Balushi, Firyal ; Al Farsi, Maathir ; Al Qurani, Marwa

IntroductionIntroduction: Junctional Epidermolysis Bullosa (JEB) is a rare subtype of the Epidermolysis Bullosa which itself is a rare genetic disorder. While mucosal involvement of pharynx and oesophagus has been reported, laryngeal involvement is rare.Case ReportA 7-month-old male child who was known to have Junctional Epidermolysis Bullosa presented to the emergency department with respiratory distress associated with a stridor which was eventfully found to have multiple level laryngeal stenosis.ConclusionsLongitudinal cohort studies are required to determine the long-term outcome and the anticipated behavior of epidermolysis bullosa in patients with laryngeal manifestation to avoid unnecessary surgical interventions.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Laryngostenosis

Basic Info

Related

Analysis