Last update 01 Nov 2024

Severe Fever With Thrombocytopenia Syndrome

Last update 01 Nov 2024

Basic Info

Synonyms

FTLS - Fever, thrombocytopenia, and leucopenia syndrome, FTLS - Fever, thrombocytopenia, and leukopenia syndrome, Infection, SFTS Virus

+ [13]

Introduction

A tick-borne infection with SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME BUNYAVIRUS of the genus Phlebovirus. It is associated with fever, THROMBOCYTOPENIA; LEUKOCYTOPENIA, and multiorgan dysfunction. It is found in parts of Asia including China, Japan, Korea and Vietnam and can be transmitted from infected domestic animals and humans.

Drugs associated with Severe Fever With Thrombocytopenia Syndrome

Favipiravir

Target

RdRp

Mechanism

RdRp inhibitors

Active Org.

R-Pharm Group [+3]

Originator Org.

Toyama Chemical Co., Ltd.

Active Indication

Severe Fever With Thrombocytopenia Syndrome [+3]

Inactive Indication

Hemorrhagic Fever, Ebola [+1]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date24 Mar 2014

VV261

Target-

Mechanism-

Active Org.

Shanghai Institute of Materia Medica Chinese Academy of Sci [+2]

Originator Org.

Wangshan Wangshui (Shanghai) Biomedicine Co., Ltd.

Active Indication

Severe Fever With Thrombocytopenia Syndrome

Inactive Indication-

Drug Highest PhaseIND Approval

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

SFTSV vaccine(Vernagen)

Target-

Mechanism

Immunostimulants

Active Org.

Vernagen Inc.

Originator Org.

Vernagen Inc.

Active Indication

Severe Fever With Thrombocytopenia Syndrome

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Severe Fever With Thrombocytopenia Syndrome

ChiCTR2400086176 / SuspendedNot ApplicableIIT

Analysis of Prognostic Risk Factors for Sever Fever with Thrombocytopenia Syndrome:A single center, retrospective study

Start Date01 Jul 2024

Sponsor / Collaborator-

ChiCTR2400082172 / SuspendedPhase 4IIT

Molnupiravir in severe fever with thrombocytopenia syndrome (SFTS): a multi-center, randomized controlled study

Start Date01 Apr 2024

Sponsor / Collaborator-

ChiCTR2400081631 / SuspendedEarly Phase 1IIT

Ruxolitinib plus standard case in severe fever with thrombocytopenia syndrome (SFTS): a multi-center, open-label, randomized controlled study

Start Date01 Apr 2024

Sponsor / Collaborator-

100 Clinical Results associated with Severe Fever With Thrombocytopenia Syndrome

100 Translational Medicine associated with Severe Fever With Thrombocytopenia Syndrome

0 Patents (Medical) associated with Severe Fever With Thrombocytopenia Syndrome

1,032

Literatures (Medical) associated with Severe Fever With Thrombocytopenia Syndrome

01 Jan 2025·Radiology Case Reports

Successful multimodal management of central nervous system solitary fibrous tumor: A case report

Article

Author: Jaouad, Mohamed Reda Cherkaoui ; Louraoui, Sidi Mamoune ; Mjabber, Reyzane El ; Gouach, Hanae El ; Chahid, Malak ; Mjabber, Reyzane EL ; Rami, Amal ; Mahdi, Youssef ; Alami, Rim ; Fliyou, Fadwa ; Kouhen, Fadila ; Karkouri, Mehdi

Solitary fibrous tumors (SFTs) are rare neoplasms that can occur in various locations, including the central nervous system (CNS). We present a case report of a 47-year-old male patient with an intracranial SFT who underwent subtotal resection followed by adjuvant radiotherapy. The patient initially presented with chronic left temporal headache and was diagnosed with an intra-axial double-component mass in the left temporoparietal lobe. Histopathological examination confirmed the diagnosis of SFT, and immunohistochemical staining demonstrated positivity for CD34, Bcl-2, and STAT6. Following the incomplete resection, the patient received adjuvant radiotherapy using volumetric modulated arc therapy (VMAT) technique. During radiotherapy, the patient experienced a spontaneous encephalocele rupture but recovered without complications. One year postradiotherapy, the patient showed no recurrence of symptoms or radiological evidence of tumor recurrence. This case highlights the challenges in the diagnosis and management of CNS SFTs and suggests that subtotal resection followed by adjuvant radiotherapy may be an effective treatment approach in achieving favorable outcomes for these rare neoplasms.

31 Dec 2024·Emerging Microbes & Infections

The first reported cases of severe fever with thrombocytopenia syndrome virus from domestic sick camel to humans in China

Article

Author: Ren, Zhenyong ; Liu, Wei ; Liu, Hui ; Ruan, Chunlai ; Sun, Yulan ; Chen, Zhihai ; Wang, Quanyi ; Zhang, Daitao ; Li, Dan ; Du, Zhizhong ; Xue, Hui ; Jin, Haoyuan ; Dou, Xiangfeng ; Ge, Ziruo

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease with an increasing annual incidence rate. In this case report, we presented two patients infected with the SFTS virus, suggesting a potential direct transmission route from camels to humans through blood contact. Both patients developed symptoms after engaging in the slaughtering of one sick camel, while their family members living in the same environment or co-diners remained unaffected. Subsequent detection revealed a high viral load of SFTS virus, reaching 10¹⁰ viral RNA copies/ml, in the sample obtained from the sick camel. Metagenomic sequencing did not identify any other pathogens. The SFTS virus was successfully isolated from both patient and camel samples. The complete nucleotide sequences obtained from the infected patients demonstrated a remarkable 100% similarity to those found in the camel, and genetic evolution analysis classified the virus as genotype A. Additionally, partial sequences of the SFTS virus were identified in ticks captured from the camel rearing environment, however, these sequences showed only 95.9% similarity to those found in camel and humans. Furthermore, immunoglobulin M and immunoglobulin G antibodies were detected in serum samples collected from the patient. Our findings provide evidence that camel may serve as a competent reservoir for transmitting the SFTS virus to humans. Further in vitro investigations into SFTS virus infections in large animals are warranted to understand their role in viral maintenance and transmission.

01 Dec 2024·Acta Tropica

Identification of severe fever with thrombocytopenia syndrome virus isolates in the northwest of Hubei Province, China

Article

Author: Qin, Xueqin ; Song, Fangmin ; Liu, Mingming ; Fu, Peixi ; Xu, Tianyi ; Meng, ZhongJi ; Cui, Fangfang ; He, Yuqian ; Wang, Chuanmin ; Peng, Yong ; Qiu, Guangyu ; Meng, Zhongji ; Peng, Yanli ; Liu, Yang ; Qin, Xin

Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral disease that is increasingly affecting human being worldwide. The clinical manifestations and mortality rates of SFTS can vary depending on the geographic region and the specific genotype of the SFTS virus (SFTSV). From July 2022 to August 2023, we collected serum samples from 83 patients with suspected SFTSV infection in the northwest of Hubei Province, China. From which, 13 patients tested positive for SFTSV. Phylogenetic analysis of the SFTSV L, M, and S gene segments was performed using the maximum likelihood method to determine the genetic diversity of the isolates. At least 2 SFTSV genotypes (A and F) were identified in the northwest of Hubei Province. The clinical manifestations and laboratory findings on the first day of admission were investigated. Results showed that bleeding and disturbance of consciousness, and significant elevated AST and APTT, are valuable for assessing the prognosis for SFTS patients. This study disclosed the genomic sequences and genotypes of SFTSV spreading in the northwest of Hubei Province for the first time, providing information of genetically etiology for SFTS in the local district. Furthermore, certain symptoms and/or laboratory findings may indicate adverse clinical outcomes, highlighting the importance of identifying the symptoms and monitoring specific laboratory markers. Future research is needed to investigate the threshold values of these markers and to closely observe the indicative symptoms in order to early identify and timely management of critically ill patients within clinical settings.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Severe Fever With Thrombocytopenia Syndrome

Basic Info

Related

Analysis