Favipiravir

RICHMOND, Va.--(BUSINESS WIRE)-- Aditxt, Inc. (NASDAQ: ADTX) (“Aditxt” or the “Company”), a global innovation company focused on innovation and activation of precision medicine therapeutics and technologies that monitor and modulate the immune system, is pleased to provide an important update regarding its innovation programs and strategic M&A initiatives. At Aditxt, our DNA is focused on bringing some of the most needed and promising health innovations and solutions to life in a faster, more efficient way. We believe strongly in the power of precision medicine, precision diagnostics and monitoring, precision prevention, and precision treatment. People deserve better than a one-size-fits-all approach to disease prevention, diagnostics, and treatments—in every area of health, including autoimmune diseases, oncology, neurology, and viral infections. As we near the end of the third quarter of 2023 and look ahead to 2024, we are focused on expanding our portfolio to include: 2 current programs in monitoring and treating autoimmunity and organ transplantation: Adimune and Pearsanta. a human clinical trial with Mayo Clinic studying the central nervous system disorder Stiff-Person Syndrome using our proprietary ADI-100™. For Q2 2023 and the first half of the Q3 2023, we have been heavily focused on ongoing conversations around promising innovations. We also mutually agreed to terminate the non-binding letter of intent with Natural State Genomics and Natural State Laboratories. Since the founding of Aditxt, we have believed that commercializing health innovations deserves a new approach driven by stakeholders. For far too long, game-changing innovations never see the light of day. Highly promising innovations, drug molecules, therapeutics, screening devices, or pieces of hardware or software, are tabled due to lack of critical infrastructure, expertise, and resources needed to survive and thrive—including, operations, finance, M&A, global partnerships, content and marketing, access to labs and research facilities, and more. We believe that the Aditxt model offers the foundation innovations needed to succeed. Finally, Aditxt was built and designed to harness the power of global capital markets and partners—from medical research institutions to software and hardware companies, manufacturing, and commercialization. As we expand, so does our ability to accelerate innovation. We are committed to advancing healthcare through innovation and precision medicine. At Aditxt, we strive to make promising innovations possible, together. Leadership Weighs In “Aditxt takes a stakeholder-driven approach to developing and deploying some of the most promising health innovations such as Pearsanta’s immune monitoring platform, and Adimune’s immune modulation therapeutic,” says Amro Albanna, Aditxt CEO, Chairman and Co-Founder. “Our goal is to get our current programs to reach key clinical or commercial stage and expand our portfolio of innovations to address additional markets such as oncology and neurology.” Aditxt Portfolio Updates Adimune™, Inc. Immune modulation program Adimune, Inc.’s immune modulation technologies are designed to retrain the immune system to restore tolerance in autoimmune diseases and allergies, and to induce tolerance in allogeneic skin transplantation. Program Highlights and Next Steps Adimune and Mayo Clinic signed a clinical trial agreement to test ADI-100™ in patients with Stiff-Person Syndrome, a rare central nervous system autoimmune disease mediated by a target antigen also implicated in T1D. - U.S. human trials are expected to be underway in Q4 2023. - Mayo Clinic is currently working to enroll 15 to 20 patients and initial screenings have begun. ADI-100™ prevented checkpoint-inhibitor-induced T1D without preventing its effectiveness in reducing cancer tumor size, demonstrating selective upregulation of regulatory cells. Clinical trial applications for psoriasis and T1D are expected to be filed with the German Health Authority in Q1 2024. Clinical grade manufacturing of clinical grade drug substances (DNA plasmids) has been completed and GMP formulation of clinical grade ADI-100™, to be used for the first-in-human studies in subjects with psoriatic lesions, is expected to be initiated. Completed the in-life portion of the toxicology studies. Safety data are recorded and Adimune is awaiting immunotoxicology data. Leadership Weighs In “This is an exciting time for Adimune. ADI-100™ is now part of an investigator sponsored study at the Mayo Clinic this year in patients with Stiff-Person Syndrome, a very severe progressive central nervous system autoimmune disorder,” says Adimune co-CEO Joachim-Friedrich Kapp, M.D., Ph.D. “Once the stability program is completed, we intend to finalize the CTA documents and apply for regulatory approval to perform clinical trials in two additional indications, T1D and psoriasis. We are optimistic that the findings in the human trials will confirm what has been established in the vast number of animal safety and efficacy studies.” Pearsanta™, Inc. “Lab testing anytime and anywhere” Pearsanta, Inc. is committed to building a “lab testing anytime and anywhere” model through three channels: Traditional lab developed tests (“LDT”s); Point of Care (“POC”) devices (i.e., “lab on a chip,”); and Direct to Consumers (“DTC”) offerings. Program Highlights and Next Steps Established immune monitoring center in Richmond, VA in 2021, for centralized and decentralized lab services. An advanced multi-spectral sensor technology platform for at-home testing is currently under development for decentralized lab services. Market roll out for at-home testing is expected to begin in Q2 2024 through brick-and-mortar retailers along with a DTC eCommerce online marketing strategy coupled with social media influencers. Continuing to expand product pipeline, research, and development, and have wider commercial reach with patients with a POC testing platform. Working to identify M&A opportunities to access new territories and markets for additional innovation expertise in the field of genetics, products, and services to deliver Pearsanta’s “Health by the Numbers” for improved health outcomes. Exploring future partnerships for the development, implementation, and distribution of a rapid PCR-based testing platform. Rapid test results will have the potential to enable almost real-time clinical decision making in prescribing the most appropriate treatment protocol for Covid, influenza, respiratory syncytial virus (RSV), urinary tract infections (UTIs), sexually transmitted Infections (STIs), strep throat, and others. Leadership Weighs In “Pearsanta’s lab testing platform is a paradigm shift in how consumers can access their healthcare on demand for immediate care,” says Ernie Lee, Head of Pearsanta. “As an example, positive lab test results from UTIs, Covid, flu, RSV, and STIs respond most effectively when treatments are started within a few days of symptoms. Through the platform, you could potentially be tested, see a health care provider, receive a prescription for a medication, if one is needed, and have the prescription filled—all in one encounter.” Adivir™, Inc. Antiviral therapeutics Adivir, Inc. is focused on catalyzing discoveries that prevent and cure infectious diseases. Program Highlights and Next Stage Continue to work towards completing the transaction for the acquisition of 50 percent ownership in G Response Aid FZCO, which includes the license to develop and commercialize 200MG Avigan® (Favipiravir), an antiviral that may be used as a mono treatment or in combination therapies. About Aditxt, Inc. Aditxt®, Inc. (NASDAQ: ADTX) is a global innovation company focused on innovation and activation of precision medicine therapeutics and technologies that monitor and modulate the immune system. Headquartered in Richmond, Virginia, with operations in Silicon Valley, California, and New York, Aditxt’s mission of “Making Promising Innovations Possible, Together” is defined by our growing ecosystem of research institutions, global industry partners, and shareholders who inform and inspire our mission. Aditxt’s diverse innovation portfolio includes: Adimune™, Inc., developing and designing a new class of therapeutics for retraining the immune system to address organ rejection, autoimmunity, and allergies; Adivir™, Inc., focused on identifying, developing and commercializing new ways to treat infectious diseases; and Pearsanta™, Inc., which offers personalized immune monitoring for a wide range of health conditions, including hereditary cancer, wounds and cardiomyopathy. For more information, visit the Company’s websites at , , and Follow us on LinkedIn for the latest company news. Forward-Looking Statements Certain statements in this press release constitute "forward-looking statements" within the meaning of federal securities laws. Forward-looking statements include statements regarding the Company's intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things, the Company's ongoing and planned product and business development; the Company’s ability to finance and execute on its strategic M&A initiatives; the Company’s ability obtain the necessary funding and partner to commence clinical trials; the Company's intellectual property position; the Company's ability to develop commercial functions; expectations regarding product launch and revenue; the Company's results of operations, cash needs, spending, financial condition, liquidity, prospects, growth and strategies; the Company’s ability to raise additional capital; the industry in which the Company operates; and the trends that may affect the industry or the Company. Forward-looking statements are not guarantees of future performance and actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors, as well as market and other conditions and those risks more fully discussed in the section titled "Risk Factors" in the Company's most recent Annual Report on Form 10-K, as well as discussions of potential risks, uncertainties, and other important factors in the Company's other filings with the Securities and Exchange Commission. All such statements speak only as of the date made, and the Company undertakes no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

This agreement is a significant step for Aditxt as it expands its portfolio to include innovative therapies for infectious diseases; Aditxt will partner with global logistics leader Agility to address a growing global market need for effective antivirals RICHMOND, Va.--(BUSINESS WIRE)-- Aditxt, Inc. (NASDAQ: ADTX) (“Aditxt” or the “Company”), a global innovation company focused on therapeutics and technologies that monitor and modulate the immune system, is pleased to announce the signing of an asset purchase agreement with Cellvera, Ltd. (”Cellvera”) that grants Aditxt (whether directly or in its recently formed wholly owned subsidiary Adivir, ™ Inc. (“Adivir”), a 50% ownership in G Response Aid FZE (“GRA” or “Global Response Aid”) with the other 50% owned by global logistics leader Agility, Inc. (KW: AGLTY) (“Agility”). The consideration for the transaction is (A) $24.5 million, comprised of: (i) the forgiveness of Aditxt’s $14.5 million loan to Cellvera, and (ii) $10 million in cash, and (B) future royalties for 7 years. Together with Dr. Reddy’s Laboratories, Ltd. (NYSE: RDY), GRA holds an exclusive, worldwide license for Avigan® 200mg, excluding Japan, China and Russia. In connection with the closing of this transaction, the Share Exchange Agreement previously entered as of December 28, 2021, between Cellvera Global Holdings, LLC f/k/a AiPharma Global Holdings, LLC (together with other affiliates and subsidiaries) and Aditxt and all other related agreements will be terminated. The closing of the transaction remains subject to a number of conditions, including but not limited to, among others, approval by Aditxt’s board of directors to enter into this transaction, financing of the purchase price, regulatory approvals for the transfer of shares, the resolution and satisfaction of all of Cellvera’s creditors inclusive of those creditors who have initiated claims, and securing the rights to additional 3rd-party IP assets. No assurance can be given that all of the conditions to closing will be obtained or satisfied, or that the transaction will ultimately close. “We believe this acquisition has the potential to help drive Aditxt’s strategic revenue and growth, as we move forward to help address a growing market need for more effective antivirals,” said Amro Albanna, co-founder, chairman and CEO of Aditxt. “We are excited by the opportunity to play a key role in the development of Avigan in terms of clinical and commercial opportunities. We believe that Avigan can play a vital role in the treatment of a range of infectious diseases, due to the broad-spectrum nature of the molecule. Although we have only recently entered into the therapeutics market, our goal is to drive a paradigm shift in the treatment and prevention of infectious diseases globally through our newly formed subsidiary Adivir.” GRA CEO Mitch Wilson said: “We’re very excited about the partnership with Aditxt. Aditxt knows how to assess, develop, and commercialize promising innovations with a focus on immune health. Its expertise is critical in helping GRA bring Avigan to its full potential.” About Aditxt, Inc. Aditxt,® Inc. (NASDAQ: ADTX) is a global innovation company focused on therapeutics and technologies that monitor and modulate the immune system. Aditxt’s mission of “Making Promising Innovations Possible, Together” is defined by our growing ecosystem of research institutions, global industry partners and shareholders who inform and inspire our mission. Aditxt’s diverse innovation portfolio includes: Adimune, Inc.™, developing and designing a new class of therapeutics for retraining the immune system to address organ rejection, autoimmunity, and allergies; Adivir, Inc.™, focused on identifying, developing and commercializing new ways to treat infectious diseases; and Pearsanta, Inc.™, which offers personalized immune monitoring intended to be informative for a wide range of health conditions, including hereditary cancer, wounds and cardiomyopathy. For more information, visit the Company’s websites at , and . Follow us on LinkedIn for the latest company news. About Agility Agility is a global leader in supply chain services, infrastructure, and innovation with 45,000+ employees across six continents. The company is a pioneer in emerging markets and specializes in growing and scaling businesses. Agility’s companies include the world’s largest aviation services company (Menzies Aviation); a global fuel logistics business (TriStar); the market leader in logistics parks across the Middle East, South Asia, and Africa (Agility Logistics Parks); and a commercial real-estate company developing a $1.2 billion mega-mall in the UAE (UPAC). Other Agility companies: customs digitization services, remote-site infrastructure services, ecommerce-enablement and digital logistics. Agility invests in supply chain innovation, sustainability, and resilience, and has stakes in a growing portfolio of listed and non-listed companies looking to reshape their respective industries across various sectors. For more information visit: . Twitter: twitter.com/agility. LinkedIn: linkedin.com/company/agility. YouTube: youtube.com/user/agilitycorp About Global Response Aid (GRA) Global Response Aid, based in Dubai, was established to address the market challenges created by the COVID-19 pandemic and other threats to public health. GRA delivers innovative, effective healthcare solutions through a range of pharmaceutical products and technology platforms. It works closely with governments, regulatory authorities, hospitals, clinics, healthcare providers, life sciences companies, NGOs and public institutions to develop strategies that allow them to tackle public health challenges. For more information visit: Forward-Looking Statements Certain statements in this press release constitute "forward-looking statements" within the meaning of federal securities laws. Forward-looking statements include statements regarding the Company's intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things, the Company's ongoing and planned product and business development; the Company’s ability to finance and execute on its strategic M&A initiatives; the Company's intellectual property position; the Company's ability to develop commercial functions; expectations regarding product launch and revenue; the Company's results of operations, cash needs, spending, financial condition, liquidity, prospects, growth and strategies; the industry in which the Company operates; and the trends that may affect the industry or the Company. Forward-looking statements are not guarantees of future performance and actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors, as well as market and other conditions and those risks more fully discussed in the section titled "Risk Factors" in the Company's most recent Annual Report on Form 10-K, as well as discussions of potential risks, uncertainties, and other important factors in the Company's other filings with the Securities and Exchange Commission. All such statements speak only as of the date made, and the Company undertakes no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.