Ligament pain

Main purpose: This study uses the arginine ibuprofen granules (specification: 0.4g (in terms of ibuprofen)) certified by Sichuan Xinston Pharmaceutical Co., Ltd. as the test preparation and the arginine ibuprofen granules (trade name: Sparta, specification: 0.4g (in terms of ibuprofen)) certified by Hainan Zanbang Pharmaceutical Co., Ltd. as the reference preparation to conduct a human bioequivalence test under fasting/postprandial conditions to evaluate the bioequivalence of the test preparation and the reference preparation in healthy subjects. Secondary purpose: Observe the safety of the test preparation and the reference preparation in healthy subjects.

Primary objective: To study the pharmacokinetics of arginine ibuprofen granules (specification: 0.4g (in terms of ibuprofen), test preparation) held by Renhe Yikang Huize Pharmaceutical Hebei Co., Ltd. in healthy subjects under fasting and postprandial conditions, using arginine ibuprofen granules (trade name: Spodek®; specification: 0.4g (in terms of ibuprofen)) held by Hainan Zanbang Pharmaceutical Co., Ltd. as the reference preparation, and evaluate whether the test preparation and the reference preparation are bioequivalent. Secondary objective: To observe the safety of the test preparation and the reference preparation in healthy subjects.

The arginine ibuprofen tablets (specification: 0.4g) produced by Hainan Zambang Pharmaceutical Co., Ltd. were used as the reference preparation to evaluate the bioequivalence of arginine ibuprofen tablets (specification: 0.4g) developed by Hainan Celik Pharmaceutical Co., Ltd. with the reference preparation.