Dihydropyrimidine Dehydrogenase Deficiency

MINNEAPOLIS--(BUSINESS WIRE)-- OneOme announces its new approach to improving medication safety for cancer patients through focused germline pharmacogenomics (PGx) testing.1,2 RightMed Oncology is uniquely designed to help oncologists elevate their standard of care – to decrease the risk of chemotherapy-induced toxicity and improve medication safety and efficacy for supportive care medications for mental health, pain management, and chemotherapy-induced nausea and vomiting. This may be achieved by tailoring medications and dosages to match the unique genetic makeup of individual patients based on established guidelines. The RightMed oncology portfolio empowers innovative health systems, oncology practices and prescribers to be as focused or comprehensive as their program requires. OneOme offers single-gene RightMed tests including DPYD (c.557A>G, HapB3, *2A, *13, and c.2846A>T variants), UGT1A1 and TMPT/NUDT15, as well as the RightMed Oncology panel test, which covers dozens of medications used as chemotherapy and supportive care. Fluorouracil injection, one chemotherapy medication covered by the RightMed Oncology test and DPYD single-gene test, recently updated labeling in collaboration with FDA to include: “Patients with certain homozygous or compound heterozygous variants in the DPYD gene are at increased risk for acute early-onset toxicity and serious, including fatal, adverse reactions... Inform patients of the potential for serious and life-threatening adverse reactions due to DPD deficiency and discuss with your patient whether they should be tested for genetic variants of DPYD that are associated with an increased risk of serious adverse reactions from the use of fluorouracil.”3 OneOme’s Chief Medical Officer, James Kelley, MD, PhD, said, “Precision medicine is enabling cancer treatment to become personalized. Using PGx can inform usage and dosage decisions for a wide range of chemotherapy and supportive care medications. It is another tool in reducing adverse drug events, predicting drug efficacy, and improving patient care.” RightMed Oncology incorporates insights from practicing oncology clinicians, a feasibility study with Mayo Clinic4, recent scientific and clinical literature, and established PGx guidelines such as the Clinical Pharmacogenetics Implementation Consortium (CPIC®) and FDA labeling. For more information about RightMed Oncology, please visit OneOmeInstitute.com/Oncology or reach out directly to discuss a PGx program for your health system. OneOme is a leader in precision medicine, providing pharmacogenomic solutions, population-level value-based care analyses, and clinical decision support solutions to health systems, health insurers, and self-insured employers. OneOme aims to improve patient safety, reduce overall cost of care, and improve patients' health outcomes. Co-founded by the Mayo Clinic, from its headquarters in Minneapolis, OneOme offers its services to clients around the world. For more information, visit . 1. Deenen MJ, Meulendijks D, Cats A, et al. Upfront genotyping of DPYD*2A to individualize fluoropyrimidine therapy: a safety and cost analysis. J Clin Oncol. 2016;34(3):227-34. 2. Hulshof EC, de With M, de Man FM, et al. UGT1A1 genotype-guided dosing of irinotecan: A prospective safety and cost analysis in poor metaboliser patients. Eur J Cancer. 2022;162:148-57. 3. FDA approves safety labeling changes regarding DPD deficiency for fluorouracil injection products, available at: . (March 21, 2024). 4. Kasi PM, Koep T, Schnettler E, Shahjehan F, Kamatham V, Baldeo C, Hughes CL. Feasibility of Integrating Panel-Based Pharmacogenomics Testing for Chemotherapy and Supportive Care in Patients With Colorectal Cancer. Technol Cancer Res Treat. 2019 Jan 1;18:1533033819873924. doi: 10.1177/1533033819873924. PMID: 31533552; PMCID: PMC6753511. View source version on businesswire.com: Contacts Travis Thompson Senior Director of Marketing, OneOme, LLC travisthompson@oneome.com Source: OneOme View this news release online at:

ROBERTS, Wis., Aug. 15, 2022 /PRNewswire/ -- Joel S. Stoeckeler, MD, is being recognized by Continental Who's Who as a Top Pinnacle Achiever for his professional excellence in Family Practice and Emergency Medicine and in acknowledgment of his achievements with Baldwin Area Medical Center (currently Western Wisconsin Health, Baldwin WI) and Aspirus Stanley Hospital in Stanley, WI. Continue Reading Joel S. Stoeckeler A board-certified physician with 37 years of experience, Dr. Stoeckeler is now semi-retired. However, he continues to practice emergency medicine as a locum tenens at Aspirus Stanley Hospital, a Level 3 Trauma Center in Stanley, WI. During his years in full-time medical practice, Dr. Stoeckeler was a Family Medicine physician for over 26 years. He additionally served as the EMS medical director for the Baldwin Ambulance Service for 18 years. In pursuit of his higher education, Dr. Stoeckeler obtained a Bachelor of Science in Experimental Psychology with a minor in Biochemistry at the University of Minnesota in 1976. He also studied classical guitar during his undergraduate studies and performed with the university's jazz ensemble. He continued his studies at the University of Minnesota, where he attended medical school, obtaining his Medical Degree in 1985. He later completed a Master of Science in Health Informatics during his Residency in Family Practice. Following medical school, Dr. Stoeckeler completed an internship in Pediatrics and a residency in Family Medicine at the University of Minnesota. Throughout his medical school and residency, he trained in Electron Microscopy and took part in medical research. He authored software for the NICU at the University of Minnesota while working on his Master's in Health Informatics. Subsequently, he co-authored medical articles focusing on his research, one of which was published in the New England Journal of Medicine in 1985, titled "Familial Pyrimidinemia and Pyrimidinuria Associated with Severe Fluorouracil Toxicity." These publications were some of the highlights of his medical education. Upon completing his Family Practice Residency, he became board-certified in Family Medicine. He joined a primary care practice in Baldwin, WI, where he continued to practice full-spectrum Family Practice for 26 years. This included family medicine clinic, obstetrics, 80,000 hours of E.R. coverage, hospitalist coverage, and general surgical assists. He also trained in upper and lower G.I. and endoscopy, performing approximately 2000 of these procedures. Additionally, he pursued coursework in Metabolism and Functional Medicine, which he applied to his Family Practice. Dr. Stoeckeler was recognized as one of America's top family doctors for 2002 – 2003 by the Consumer's Research Council of America and received a 2005 businessman of the year award from the Business Advisory Council of the National Republican Congressional Committee. He maintains professional membership with the American Academy of Family Practice and the American Board of Family Medicine, among his professional affiliations. Dr. Stoeckeler continued to enjoy music throughout his life, playing guitar and piano. In addition to his primary career path, he contributed nearly three years of community service with the Armed Forces Professional Entertainment Overseas Program (AFPEO), currently called Armed Forces Entertainment (AFE) and USO. He volunteered intermittently as a civilian DOD contractor between 1978 and 1996, producing and performing in overseas musical entertainment for U.S. military personnel stationed at remote and forward operating bases worldwide. Some of the operations supported include the following: Desert Storm, Operation Deny Flight, Operation Safe Haven, Operation Uphold Democracy, and Operation Joint Endeavor. Dr. Stoeckeler recalls these experiences as some of the highlights of his life and provided great insights and conversations with the many veterans he cared for in his medical practice. On a personal note, Dr. Stoeckeler is happily married, and his immediate family includes his wife, his daughter, and a son who is married with two children. He spends his free time enjoying family, the outdoors, hunting, hobby farming, playing piano, writing, and recording. Dr. Stoeckeler wishes to dedicate this honorable recognition with special thanks to his mother and father, the USO, AFPEO/AFE, and his colleague and mentor, Dr. Neal Melby, who greatly inspired him during his career. Contact: Katherine Green, 516-825-5634, [email protected] SOURCE Continental Who's Who