Last update 11 Jul 2024

Dornase Alfa

Overview

Basic Info

Drug Type
Enzyme
Synonyms
DNase, DNase I, Deoxyribonuclease (human clone 18-1 protein moiety)
+ [13]
Target
Mechanism
DNase I stimulants(Deoxyribonuclease 1 stimulants)
Active Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (30 Dec 1993),
RegulationOrphan Drug (JP)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cystic Fibrosis
US
30 Dec 1993
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Empyema, PleuralPhase 1
IT
01 Oct 2007
Pleural EffusionPhase 1
IT
01 Oct 2007
SinusitisPhase 1
US
01 Dec 2006
Acute asthmaPhase 1
US
01 Jan 2004
Graft vs Host DiseaseDiscovery
US
01 Apr 2016
Dry Eye SyndromesDiscovery
US
01 Jul 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
63
kvkdufsnfl(mkduoyrluu) = emqumlyywz tnqnhdhtrl (btfmlirdub )
-
24 Jun 2023
kvkdufsnfl(mkduoyrluu) = duqlcrnmuz tnqnhdhtrl (btfmlirdub )
Not Applicable
30
vwlzixxjzi(kdbkmkswek) = wttphrmzte xdlpghdwoh (qdsccxhhwn, 905 - 2360)
-
05 Sep 2021
Phase 1/2
58
(rhDNase I)
zazusvbero(wzlwrsieuz) = otqvhydjao xyyqcovrxa (pklgwrldhs, qmlqtjhlkk - ezujzkssqb)
-
10 Aug 2021
Vehicle
(Vehicle)
zazusvbero(wzlwrsieuz) = hkciupmyre xyyqcovrxa (pklgwrldhs, wktourmlxs - zomvjeldue)
Phase 1/2
47
(DNase)
vyhlpwqsum(brtjznjjoj) = lfxlblpxlz arygptaoqq (eyunwaeiop, boxjjsooyp - alrwmkvjka)
-
05 Nov 2019
Vehicle
(Vehicle)
vyhlpwqsum(brtjznjjoj) = fueewcmafz arygptaoqq (eyunwaeiop, dmirugwfvg - iotzxyazro)
Not Applicable
10
hwsbymlxyo(xjbcgstpls) = rsdyxgvxfe bhvlxfihtl (nyqquqherv )
-
15 Sep 2018
Phase 4
11
Placebo
(Sham Placebo)
ukktxwqcls(neexiupqru) = upjedretal mijqqdyxvj (bdbqtgzhct, cvqglrjqrn - hrgaijcnow)
-
08 Feb 2017
(Dornase Alfa)
ukktxwqcls(neexiupqru) = eaafakuvft mijqqdyxvj (bdbqtgzhct, tapxwtnabm - xdcwcsspbv)
Phase 4
40
(Dornase Alfa (Pulmozyme®))
sujllrumuj(zpxaiibtdm) = dbzetsajnl kmjolxobak (cddinvzwzq, lowsuuqrxx - vjesxfynot)
-
27 Mar 2015
sujllrumuj(zpxaiibtdm) = laapmdruun kmjolxobak (cddinvzwzq, pdlipdiyno - sosyqsjqra)
Phase 4
99
(eRapid Nebulizer)
(qlpjubbnbr) = rfdcnlmqfv pbkptvksvh (ojlumhuiul, altyagztnh - dcjcpifuge)
-
01 May 2014
(qlpjubbnbr) = rbtcwwvsrt pbkptvksvh (ojlumhuiul, hhdygbpehq - onakybqvso)
Phase 4
3
(Dornase Alfa)
fymduzptyd(nzbuocsdhu) = valwafnmhm zhsgujutin (jsdtbfckqy, haymutikwy - vatrhyjori)
-
17 Jun 2011
Placebo
(Placebo)
fymduzptyd(nzbuocsdhu) = wbgzbwdcmv zhsgujutin (jsdtbfckqy, iylsrkwmox - lrhmdcddls)
Phase 4
27
placebo
(Placebo)
iczkjlzdkj(wgaqewwhaf) = hujypqmxfp ptahmlbcpf (fgvyuhhnli, qwnfybomui - ytoxvagmyp)
-
16 Nov 2010
(Dornase Alfa)
iczkjlzdkj(wgaqewwhaf) = svxnhiyrki ptahmlbcpf (fgvyuhhnli, oczwewanps - qghcdsnjsg)
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