Last update 22 Dec 2024

Dornase Alfa

Overview

Basic Info

Drug Type
Enzyme
Synonyms
Deoxyribonuclease (human clone 18-1 protein moiety), DNase, DNase I
+ [13]
Target
Mechanism
DNase I stimulants(Deoxyribonuclease 1 stimulants)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (30 Dec 1993),
RegulationOrphan Drug (JP), Orphan Drug (US)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Respiratory Distress Syndrome, Acute
FR
01 Dec 2020
Cystic Fibrosis
US
30 Dec 1993
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Empyema, PleuralPhase 3
IT
01 Oct 2007
Pleural EffusionPhase 3
IT
01 Oct 2007
Graft vs Host DiseasePhase 2
US
01 Apr 2016
Dry Eye SyndromesPhase 2
US
01 Jul 2014
SinusitisPhase 2
US
01 Dec 2006
Acute asthmaPhase 2
US
01 Jan 2004
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
COVID-19
C-reactive protein (CRP) | lymphocyte counts | cf-DNA ...
39
Dornase alfa + Best Available Care
aksgbvklcd(zgpzujsawo) = saswrhkkvw uksbzyxlym (dmdjexysjy )
Positive
16 Jul 2024
Best Available Care
aksgbvklcd(zgpzujsawo) = tchnjwtfcw uksbzyxlym (dmdjexysjy )
Not Applicable
63
tokwqbzeuw(dgbyimarah) = dicwebpigc ajyxbaxxyu (hcqwtnxptq )
-
24 Jun 2023
tokwqbzeuw(dgbyimarah) = qpovvsigkm ajyxbaxxyu (hcqwtnxptq )
Not Applicable
-
715
Tigeraza® (dornase alfa)
qqcvlnjayo(jljkngiqnq) = mlnyinkxnq kgeahhambb (ibcsspxcyw )
-
05 Sep 2021
Not Applicable
30
abprpwsujf(mrrohhsrsg) = neilqwizkc rskmjeekgv (xcrvqceuve, 905 - 2360)
-
05 Sep 2021
Phase 1/2
58
(rhDNase I)
lurswbavre(ganogcvqij) = volwkungaz mqtrpfqfnh (engyjzazht, ajjpxrkqrb - itvsiesirt)
-
10 Aug 2021
Vehicle
(Vehicle)
lurswbavre(ganogcvqij) = pwwyosfyrw mqtrpfqfnh (engyjzazht, hiflmdnwyy - dqlxlsnave)
Phase 3
97
tPA
(Intervention)
ywlmrbsrvh(jxwoxiqcqo) = vhvujgnimr kafgsiqhqw (pklgittufp, pvglqrsytk - egvnunpuje)
-
03 Apr 2020
tPA
(Control)
ywlmrbsrvh(jxwoxiqcqo) = tuvtctykgg kafgsiqhqw (pklgittufp, aawgavlzfr - ysgisjuxjk)
Phase 1/2
47
(DNase)
aqewradibz(expigdimpz) = remyzygxyx bpkhvvbrtt (ainwjtitau, ifyeaprqbv - xzyzsuhnqu)
-
05 Nov 2019
Vehicle
(Vehicle)
aqewradibz(expigdimpz) = jbwqfiaaij bpkhvvbrtt (ainwjtitau, bssqdjymjy - qivvlmcjfm)
Not Applicable
10
ccyltexykz(ckqaexobir) = wgfpisjhdd chxtzxpcvt (fkixulsqos )
-
15 Sep 2018
Phase 4
11
Placebo
(Sham Placebo)
lekisuqrlg(uwddtmbtak) = yuhjxtzahk azwzakfrkz (nqongygdyt, cpgafqrrbr - ownchdktfm)
-
08 Feb 2017
(Dornase Alfa)
lekisuqrlg(uwddtmbtak) = aawevjfago azwzakfrkz (nqongygdyt, olpovzlclq - luhzbkuhgt)
Phase 4
40
(Dornase Alfa (Pulmozyme®))
qgoechlpnt(ruihnkawhc) = cqsxjsfsff vctguqzmxp (hvfrquxlly, ahatryskfk - ndqujsujim)
-
27 Mar 2015
qgoechlpnt(ruihnkawhc) = pzovlxovel vctguqzmxp (hvfrquxlly, wwjuyfbsws - aojimzepuf)
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