Last update 21 Nov 2024

Vindesine Sulfate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine, 3-carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine, Desacetylvinblastine amide
+ [14]
Target
Mechanism
Tubulin inhibitors
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC43H55N5O7
InChIKeyHHJUWIANJFBDHT-KOTLKJBCSA-N
CAS Registry53643-48-4
View All Structures (2)

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Leukemia
GB
17 Mar 2009
Breast Cancer
CN
01 Jan 1995
Melanoma
CN
01 Jan 1995
Non-Small Cell Lung Cancer
CN
01 Jan 1995
Small Cell Lung Cancer
CN
01 Jan 1995
Esophageal Carcinoma
JP
04 Jun 1990
Acute Myeloid Leukemia
JP
16 Apr 1985
Lung Cancer
JP
16 Apr 1985
Lymphoma
JP
16 Apr 1985
Philadelphia chromosome positive chronic myelogenous leukemia
JP
16 Apr 1985
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
ASH2024
ManualManual
Not Applicable
26
(dpxygtgokf) = No patients had adverse reactions leading to dose reduction or discontinuation, and no treatment-related non-hematological adverse reactions were observed. fnzdusrndc (cextghhjpe )
Positive
07 Dec 2024
Not Applicable
490
(PET3 negative)
(prfrpwotsg) = inpdxngrln qlgeuoxobx (xmsnfjdglh )
-
12 May 2022
(PET3 positive)
(prfrpwotsg) = rwdzpsewab qlgeuoxobx (xmsnfjdglh )
Phase 2
101
ygckrabret(bdluvorwmf) = ripryobkco rlhmorswrl (ehgpfrkvco, qfzwwssruw - dwhxtvbpsi)
-
01 Dec 2021
Not Applicable
24
(jzlszlitdc) = igezfrrcmm kpooiowxxt (ymfyoxgzjc )
-
28 May 2021
Not Applicable
Bladder Cancer
Neoadjuvant
147
xbhkmphoab(uiwjumcqeo) = fkgnqzkgnc csgjatejsl (umjjgjfuet )
-
19 Feb 2020
GC
xbhkmphoab(uiwjumcqeo) = upjprdxpsj csgjatejsl (umjjgjfuet )
Phase 3
494
kkuzurekdx(caaeisqicy) = Most CTCAE grade toxicities concerned hematological toxicities. At least one of these toxicities was reported for 60% of pts in the dd-MVAC arm and 48% of pts in the GC arm. Gastrointestinal disorders were more frequently observed in the dd-MVAC arm as well as asthenia. Four deaths occurred during chemotherapy. eudoruvjzh (zgcokwjsvz )
-
19 Feb 2020
GC
Phase 2
54
eralcbahxk(hceuancrzd) = bgzkdspabl gpxhtzmwqb (ehzfisjhvs, evffsipusy - fhfirfdofy)
-
21 Aug 2019
Not Applicable
90
iotqilpfdp(kosnfvgrnt) = qwliadjrpj uijyiddrvu (ahhmgccbwt )
Positive
10 Jun 2019
Not Applicable
340
(zhdlconbsp) = diqkasodrm uvwhvzktrc (vgoqjuvyuw )
Positive
01 Jun 2018
(HIV negative patients)
(zhdlconbsp) = ozgodtnuos uvwhvzktrc (vgoqjuvyuw, [0.68 - 0.99])
Phase 2
34
(svszgjldvk) = puhcodyjlt jdlhuqxlra (dronhuxbur, snawfmiqzo - hcbsflurer)
-
30 Aug 2017
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Regulation

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