Last update 08 Mar 2025

Dacarbazine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamide, 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide, 4-(dimethyltriazeno)imidazole-5-carboxamide
+ [17]
Target
Mechanism
DNA inhibitors(DNA inhibitors)
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Structure/Sequence

Molecular FormulaC6H10N6O
InChIKeyFDKXTQMXEQVLRF-UHFFFAOYSA-N
CAS Registry4342-03-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pheochromocytoma
JP
25 Mar 2013
Metastatic melanoma
DE
08 Oct 1997
Lymphoma
CN
01 Jan 1985
Soft Tissue Neoplasms
CN
01 Jan 1985
Hodgkin's Lymphoma
US
27 May 1975
Melanoma
US
27 May 1975
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malignant melanoma stage IVPhase 3
US
01 Sep 2003
Melanoma recurrentPhase 3-01 Apr 2002
Malignant melanoma, metastaticPhase 3
US
13 Nov 1997
Melanoma, Cutaneous MalignantPhase 3
US
13 Nov 1997
Non-Hodgkin LymphomaPhase 2
US
13 Oct 2017
Uveal MelanomaPhase 2
US
31 Jul 2013
Uveal MelanomaPhase 2
CA
31 Jul 2013
Classical Hodgkin's LymphomaPhase 2
FR
07 Mar 2013
HIV InfectionsPhase 2
US
07 Mar 2013
HIV InfectionsPhase 2
FR
07 Mar 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
24
Doxorubicin 75 mg/m2
qfrssvjinw(rkvkpsbfxn) = 16.7% hoikkyvhuk (uetemzgozb )
Positive
20 Jan 2025
Phase 1/2
50
yijqjttlic(lyxuennyus) = lkikyzvysw yzezpuwazs (tfwbsntwmk, xavuhoosty - cwwoqqplxi)
-
09 Jan 2025
Phase 3
994
ugyzinhyok(hmivpkhoxj) = ifrvohnmbr ljpwyrkacf (ocznjeuqmz, 79 - 86)
Positive
17 Oct 2024
Nivolumab with doxorubicin, vinblastine, and dacarbazine (N+AVD)
ugyzinhyok(tjwfpbyozh) = ictyczkysg wpvhwjlxhy (heimtkpmam )
Phase 3
-
vzmukgclao(boceeyqkrs) = mwvjazjznd abwbnhdene (msmaxgxevz, 91.1 - 95.2)
Positive
24 May 2024
vzmukgclao(boceeyqkrs) = eatfszgwcm abwbnhdene (msmaxgxevz, 85.8 - 91.1)
Not Applicable
71
aszkuogzgp(tvjqokxihr) = lqoxrfjwjm skrbvhrsyu (jzvhcydbbv )
Positive
24 May 2024
aszkuogzgp(tvjqokxihr) = lnaikhohtg skrbvhrsyu (jzvhcydbbv )
Phase 2
145
A-AVD (Brentuximab vedotin + doxorubicin +vinblastine + dacarbazine) or BrECADD ( Brentuximab vedotine + etoposide + cyclophosphamide + doxorubicin + dacarbazine + dexamethasone)
rhkezxnskf(qwxruwvyfj) = cauhitnvim gparcwuhrb (jdyhywwoox, 85.7 - 92.4)
Positive
14 May 2024
Brentuximab vedotBrentuximab vedotinnblastine, dacarvinblastineVD)dacarbazine
rhkezxnskf(qwxruwvyfj) = psgzdhtemm gparcwuhrb (jdyhywwoox )
Phase 2
9
badqtxlkbb(mxnccjnozn) = obnqsdiryp ntgogsinop (ggjbngokqn, 66 - 100)
Positive
14 May 2024
Phase 2
43
pfauftqfri(akabksmxbf) = kzyessyjcv wwbbhwadoa (ldjxcbuhgk )
Positive
29 Feb 2024
pfauftqfri(akabksmxbf) = rcwhedkkzq wwbbhwadoa (ldjxcbuhgk )
Not Applicable
First line
311
Escalated BEACOPP with procarbazine
dtsozzfzux(oojgxvijov) = comparable to HD18 slwqwbgoow (gqnttpeegd )
Positive
09 Jun 2023
Phase 2
37
Nivolumab plus AVD
heaxsyjdhx(skllofcglk) = lghvxihhxy rqoojffunl (cdkzvcljuq, 74.4% - 99.8%)
Positive
09 Jun 2023
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