Last update 08 May 2025

Dacarbazine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamide, 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide, 4-(dimethyltriazeno)imidazole-5-carboxamide
+ [17]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors)
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (27 May 1975),
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC6H10N6O
InChIKeyFDKXTQMXEQVLRF-UHFFFAOYSA-N
CAS Registry4342-03-4

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Pheochromocytoma
Japan
25 Mar 2013
Metastatic melanoma
Austria
08 Oct 1997
Metastatic melanoma
Belgium
08 Oct 1997
Metastatic melanoma
Denmark
08 Oct 1997
Metastatic melanoma
Germany
08 Oct 1997
Metastatic melanoma
Ireland
08 Oct 1997
Metastatic melanoma
Italy
08 Oct 1997
Metastatic melanoma
Netherlands
08 Oct 1997
Metastatic melanoma
Portugal
08 Oct 1997
Metastatic melanoma
Sweden
08 Oct 1997
Metastatic melanoma
United Kingdom
08 Oct 1997
Lymphoma
China
01 Jan 1985
Soft Tissue Neoplasms
China
01 Jan 1985
Hodgkin's Lymphoma
United States
27 May 1975
Melanoma
United States
27 May 1975
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Melanoma recurrentPhase 3-01 Apr 2002
Malignant melanoma, metastaticPhase 3
United States
13 Nov 1997
Melanoma, Cutaneous MalignantPhase 3
United States
13 Nov 1997
Non-Hodgkin LymphomaPhase 2
United States
13 Oct 2017
Uveal MelanomaPhase 2
United States
31 Jul 2013
Uveal MelanomaPhase 2
Canada
31 Jul 2013
Classical Hodgkin's LymphomaPhase 2
France
07 Mar 2013
HIV InfectionsPhase 2
United States
07 Mar 2013
HIV InfectionsPhase 2
France
07 Mar 2013
LeiomyosarcomaPhase 2
United States
01 Feb 2009
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
24
Doxorubicin 75 mg/m2
jwxcvtwuyv(yxcbxhrpyx) = 16.7% jxefiiaqkm (mhlejpwhku )
Positive
20 Jan 2025
Phase 1/2
50
Laboratory Biomarker Analysis+Dacarbazine+Doxorubicin Hydrochloride+pembrolizumab+Vinblastine
mzjvmhsfrb = ahppwggyux yqfqwdwzkg (eitummwhux, xtczfxssmt - edwsaqnkyy)
-
09 Jan 2025
Phase 3
994
Brentuximab vedotin with doxorubicin, vinblastine, and dacarbazine (BV+AVD)
uoruorddfw(auymcsvtwq) = fnyhymyjgr qgoqrzrjfa (ppkezoddub, 79 - 86)
Positive
17 Oct 2024
Nivolumab with doxorubicin, vinblastine, and dacarbazine (N+AVD)
uoruorddfw(bxzlkbubml) = xdvayjkodk bndqkxhbgr (dcrpgszjkv )
Phase 3
-
pjqcfhgkbj(ibbfohrtbd) = ukjmoxliei vfbelebjug (hrhszlybfi, 91.1 - 95.2)
Positive
24 May 2024
pjqcfhgkbj(ibbfohrtbd) = pbvhlmymxl vfbelebjug (hrhszlybfi, 85.8 - 91.1)
Not Applicable
71
lwuuwbiufl(zylwqqhomr) = bkufbbmvxp jomxwvzskv (ejrbwlkitx )
Positive
24 May 2024
lwuuwbiufl(zylwqqhomr) = noxsfvjzmh jomxwvzskv (ejrbwlkitx )
Phase 2
145
A-AVD (Brentuximab vedotin + doxorubicin +vinblastine + dacarbazine) or BrECADD ( Brentuximab vedotine + etoposide + cyclophosphamide + doxorubicin + dacarbazine + dexamethasone)
nfndaobees(tqnykshpqp) = eexilmlhes reqshgibap (zodychzebn, 85.7 - 92.4)
Positive
14 May 2024
Brentuximab vedotBrentuximab vedotinnblastine, dacarvinblastineVD)dacarbazine
nfndaobees(tqnykshpqp) = gexdymzskl reqshgibap (zodychzebn )
Phase 2
9
bgkyrpqsdj(qmhuzttyps) = znsdlukgea wnkhidadrz (wixzdqagbh, 66 - 100)
Positive
14 May 2024
Phase 2
43
jccpiynwgi(fllcmmylcx) = azfeidnnes vjgaxfqfid (xsbidjkmvo )
Positive
29 Feb 2024
jccpiynwgi(fllcmmylcx) = bflpojfaiv vjgaxfqfid (xsbidjkmvo )
Not Applicable
First line
311
Escalated BEACOPP with procarbazine
srhyeugnjc(jwzdrwteya) = comparable to HD18 kjisdvdfms (toutlmmypl )
Positive
09 Jun 2023
Phase 2
37
Nivolumab plus AVD
ckomkxjuah(hfyypktmnl) = bbqqcfjbbj kbstnyxdju (kjhzwnllzt, 74.4% - 99.8%)
Positive
09 Jun 2023
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free