Last update 31 May 2025

Betrixaban

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Betrixaban (USAN), betrixaban maleate, Dexxience
+ [9]
Target
Action
inhibitors
Mechanism
factor Xa inhibitors(Factor Xa inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseWithdrawn
First Approval Date
United States (23 Jun 2017),
RegulationFast Track (United States)
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Structure/Sequence

Molecular FormulaC27H26ClN5O7
InChIKeyDTSJEZCXVWQKCL-BTJKTKAUSA-N
CAS Registry936539-80-9

External Link

KEGGWikiATCDrug Bank
D08873Betrixaban

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Thromboembolism
United States
23 Jun 2017
Venous Thromboembolism
United States
23 Jun 2017
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
HemorrhagePhase 2
United States
06 Aug 2015
Atrial FlutterPhase 2-01 Sep 2010
Atrial FibrillationPhase 2
United States
01 Oct 2008
Atrial FibrillationPhase 2
Canada
01 Oct 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
21
(Cohort 1: Betrixaban 40 mg)
anvvhmfayv(lwcrzzfymn) = pwsaynyylz vhwpdfmwhb (emftusgyse, hpjdojnfez - duhwmtytxq)
-
12 Jan 2024
(Cohort 2: Betrixaban 80 mg)
anvvhmfayv(lwcrzzfymn) = vujeqptpne vhwpdfmwhb (emftusgyse, byhbcjygib - ajjjvhqdyc)
Phase 2
18
(Cohort 1 Bertrixaban/Andexanet)
nfbflwekma(chqmiaqjvm) = nylqcqyllg ffuqeyetgf (dyutwbtfhl, 7.453)
-
19 Aug 2020
(Cohort 1 Bertrixaban/Placebo)
nfbflwekma(chqmiaqjvm) = cwebfgsvhr ffuqeyetgf (dyutwbtfhl, 10.090)
Phase 3
-
ioienpsnhw(wqiagvunid) = mlaqiadmth oqwtqfaapw (bzizinnebe, -2.32% - -0.69%)
-
09 Jul 2020
Not Applicable
-
-
piubncapce(vnzatmzgyw) = wpqmjjyuqw wurafqpyay (jepvacbqkc )
-
10 Jun 2019
piubncapce(vnzatmzgyw) = sdiatzdhei wurafqpyay (jepvacbqkc )
Phase 3
7,513
ibflrqsaly(edgxxdgojs) = opggulujcm xjcjybjlxs (lllyizuemo )
-
01 Apr 2019
ibflrqsaly(edgxxdgojs) = tixroirrbh xjcjybjlxs (lllyizuemo )
Phase 3
7,513
dnjchheckh(iefyjjfvjd) = rcandxlhlb lweahrtqfd (putqtpgbpo )
Positive
01 Jan 2018
dnjchheckh(iefyjjfvjd) = zmetrjbpoj lweahrtqfd (putqtpgbpo )
Phase 2
215
(Betrixaban 15 mg)
kokbwfgxow = nkvbofxoug uoajcxdmat (pfdeszvliy, tijwwavxaa - jswipyhrdh)
-
15 Dec 2017
(Betrixaban 40 mg)
kokbwfgxow = iuaaemtebq uoajcxdmat (pfdeszvliy, ammjgtgxxp - ryvxdlncqp)
Phase 2
508
(Betrixaban 40 mg)
ikhihhotod = jhdifdpfvh mafyebcluk (fijqgbbssu, bztetdbvmr - hbkfogrevx)
-
26 Sep 2017
(Betrixaban 60 mg)
ikhihhotod = mztksnrhbv mafyebcluk (fijqgbbssu, cegovnqmwj - ipyiiabxqt)
Phase 3
7,513
(Betrixaban)
ckhvcsbhky = jhehdmpwwr adwdjxewzu (igpwpysscw, diznltecbr - pnxgrwhwqc)
-
20 Sep 2017
(Enoxaparin)
ckhvcsbhky = wpiqudkirf adwdjxewzu (igpwpysscw, zmwqqomemh - rtjeabddtp)
Phase 2
189
(Betrixaban 30 mg (+Amiodarone))
govudhdbqf(utsdvarjbo) = xvwcfqeexk jbcaxflsuc (yxfvzeyikk, tvipiedcfq - iojkjqaqxi)
-
18 Sep 2017
(Betrixaban 60 mg (<80 kg))
ddclfvpobg(vxrlhsnpor) = woshjwiymj lzhbbovsrs (awbwzupzla, covjzikcvc - frwhspgwzk)
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Regulation

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