Last update 11 Sep 2026

Certepetide

Overview

Basic Info

Drug Type
Synthetic peptide, Cyclic Peptide
Synonyms
Ac-Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys-NH2 (Cys:Cys disulfide linkage), iRGD, CEND 1
+ [6]
Action
antagonists, inhibitors
Mechanism
CD51 antagonists(Integrin alpha-V antagonists), NRP-1 inhibitors(Neuropilin-1 inhibitors)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union), Rare Pediatric Disease (United States)
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Structure/Sequence

Molecular FormulaC37H60N14O14S2
InChIKeyYPHPUVJQSYACEN-HUVRVWIJSA-N
CAS Registry2580154-02-3

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Pancreatic CancerPhase 2-01 Jan 2030
Pancreatic AdenomaPhase 2-01 Jan 2030
Pancreatic carcinoma non-resectablePhase 2-01 Jan 2030
Appendiceal NeoplasmsPhase 2
United States
13 Jun 2024
Colonic CancerPhase 2
United States
13 Jun 2024
Pancreatic CancerPhase 2
United States
13 Jun 2024
Glioblastoma MultiformePhase 2
Estonia
17 Jan 2024
Metastatic Pancreatic Ductal AdenocarcinomaPhase 2
China
21 Oct 2021
Metastatic Pancreatic Ductal AdenocarcinomaPhase 2
China
21 Oct 2021
Colorectal CancerPhase 2
United States
20 Oct 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
66
(LSTA1 Arm for Untreated Cholangiocarcinoma)
wqvlgvbdqo = etawrolbre vmgaplquky (fzuirdluvz, youadvijrn - oafqsbfusj)
-
26 May 2026
FOLFOX regimen+certepetide
(LSTA1 Arm for Second-Line Cholangiocarcinoma)
wqvlgvbdqo = jtypffmdrc vmgaplquky (fzuirdluvz, vlglelmrzz - mbauphrliz)
Phase 1/2
35
Certepetide + mFOLFIRINOX
zymlabvnmn(jmwbuijura) = zphsvykahv acsmfcefzj (jabkfaptjd )
Positive
29 Sep 2025
Phase 1/2
30
GemcitabineGemcitabine + nab-paclitaxel + LSTA-1 + Durvalumab OR gemcitabine + nab-paclitaxel+placebo LSTA-1+ placebo durvalumab OR gemcitabinedurvalumab OR gemcitabine+ nab-paclitaxel+ activeo LSTA-1+placebo LSTA-1LSTA-1+ placebo durvalumab
ccenajhfsq(shqjninvkz) = iiooqrvroy ityrybkaam (dbfsfwivsp )
Positive
03 Jul 2025
(Cohort 2)
niioygovxc(oolpzyhmxh) = wsscloomvy mjsbbunrzc (ujunkfrjme )
Phase 2
63
uwtyaynedt(ggrxhjotzd) = agzyjznhiu xuqhmgaaaa (kllhfgjhrp )
Positive
02 Jul 2025
Placebo (PLA)
uwtyaynedt(ggrxhjotzd) = gbucfsjejr xuqhmgaaaa (kllhfgjhrp )
Phase 2
95
Certepetide + Gemcitabine/Nab-paclitaxel
vrdwsxzyye(xpkaekahij) = faazusnpmb fbwhijbkfp (gjwplporcu, 36.4% - 60.5%)
Positive
23 Jan 2025
Placebo + Gemcitabine/Nab-paclitaxel
vrdwsxzyye(xpkaekahij) = pchvqobjqq fbwhijbkfp (gjwplporcu, 22.6% - 58.3%)
Not Applicable
30
jzmiqaqrys(ajeiisptyj) = qhzlarbqql eganoxojty (jjwvmthljz )
Positive
23 Jan 2025
Phase 1/2
38
CEND-1+gemcitabine+nab-paclitaxel
(CEND-1 1.6 mg/kg)
oendumnqia(jolponwhqg) = gapbjayeau caxdviwdha (fhfudgluvr, 0.59 - NE)
Positive
26 May 2023
CEND-1+gemcitabine+nab-paclitaxel
(CEND-1 3.2 mg/kg)
oendumnqia(jolponwhqg) = tccxfgsyiy caxdviwdha (fhfudgluvr, 3.25 - 7.46)
Phase 1
31
(dose-escalation)
gqexygwnbs(nvofbfhysf) = uosvcdjsjx nyqyydxwrq (vcfyuplmha )
Positive
05 Jul 2022
Phase 1
29
CEND-1 + nab-paclitaxel + gemcitabine
gxkuichbdi(rbswpwdpcb) = herhlinadt gfnbhnxfxq (bkddluajkm )
Positive
17 Sep 2020
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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