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Last update 19 May 2025
Brinzolamide/Timolol Maleate
Last update 19 May 2025
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms Azarga, Brinzolamide and Timolol Maleate, Brinzolamide/timolol + [5] |
Target |
Action inhibitors, antagonists |
Mechanism CA2 inhibitors(Carbonic anhydrase II inhibitors), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date European Union (25 Nov 2008), |
Regulation- |
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Structure/Sequence
Molecular FormulaC29H49N7O12S4 |
InChIKeyFKDJRZZKCVSAFW-WILCOHJVSA-N |
CAS Registry2449762-58-5 |
Related
20
Clinical Trials associated with Brinzolamide/Timolol MaleateCTIS2023-506494-35-00
A Therapeutic Non-Inferiority, Randomized, Observer-blind, Active-reference, Two-arm, Parallel Group, Multi-center Clinical Trial for Comparing the Efficacy and Tolerability of a Generic Fixed Combination of Brinzolamide 10mg/ml + Timolol 5mg/ml Eye Drops versus Azarga® 10mg/ml + 5mg/ml Eye Drops in the Treatment of Intraocular Pressure in Patients with Open Angle Glaucoma or Ocular Hypertension - BECRO/OV/BRINZOTIM
EUCTR2016-000946-69-AT
A PHASE III, MULTICENTRE, RANDOMISED, INVESTIGATOR-MASKED, CROSS- OVER, COMPARATIVE CLINICAL TRIAL EVALUATING THE EFFICACY AND SAFETY OF THE GENERIC BRINZOLAMIDE 10 MG/ML + TIMOLOL 5 MG/ML EYE DROPS SUSPENSION (AZAD PHARMA AG) WITH BRINZOLAMIDE 10 MG/ML + TIMOLOL 5 MG/ML EYE DROPS SUSPENSION AZARGA® (ALCON LTD) IN OPEN- ANGLE GLAUCOMA AND OCULAR HYPERTENSION PATIENTS - Azad Brinolamid/Timolol combination generic study
NCT02325518
The Efficacy and Safety of Brinzolamide 1%/Timolol 0.5% Fixed Combination Versus Dorzolamide 1%/Timolol 0.5% in Patients With Open-Angle Glaucoma and Ocular Hypertension
100 Clinical Results associated with Brinzolamide/Timolol Maleate
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100 Translational Medicine associated with Brinzolamide/Timolol Maleate
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100 Patents (Medical) associated with Brinzolamide/Timolol Maleate
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26
Literatures (Medical) associated with Brinzolamide/Timolol Maleate01 Dec 2023American journal of ophthalmology case reports
PreserFlo Microshunt for the management of intraocular pressure elevation in iridocorneal endothelial syndrome
Author: Eadie, Brennan D ; Ruparelia, Sunil ; Darwich, Rami
01 Jan 2022Vestnik oftalmologii
Efficacy and safety of a fixed combination drug Brinzolol Duo in the treatment of patients with primary open-angle glaucoma
Article
Author: Loskutov, I A ; Lisitsyn, A B ; Kolotilina, N E ; Poromov, A A ; Bleskina, M Yu
10 Aug 2020Journal of Ophthalmology
Daily Costs and Cost Effectiveness of Glaucoma Fixed Combinations in China
Article
Author: Liu, Wei ; Ji, Jian ; Huang, Dandan ; Guo, Ruru ; Xu, Chenjia
100 Deals associated with Brinzolamide/Timolol Maleate
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External Link
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
R&D Status
10 top approved records. to view more data
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| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Glaucoma | Japan | 20 Sep 2013 | |
| Glaucoma, Open-Angle | European Union | 25 Nov 2008 | |
| Glaucoma, Open-Angle | Iceland | 25 Nov 2008 | |
| Glaucoma, Open-Angle | Liechtenstein | 25 Nov 2008 | |
| Glaucoma, Open-Angle | Norway | 25 Nov 2008 | |
| Ocular Hypertension | European Union | 25 Nov 2008 | |
| Ocular Hypertension | Iceland | 25 Nov 2008 | |
| Ocular Hypertension | Liechtenstein | 25 Nov 2008 | |
| Ocular Hypertension | Norway | 25 Nov 2008 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Not Applicable | 38 | rhyqudgdbz(blikoyytvv) = tnfjsxczug pgeintiiox (azihtgidzb ) | - | 01 Sep 2016 | |||
rhyqudgdbz(blikoyytvv) = vykwmzmuzj pgeintiiox (azihtgidzb ) | |||||||
Phase 4 | 57 | qwhzbrxtvv(qkczjmfokx) = zcqzpefnvm yknlmhuhzs (ynwxhzicuj, 3.150) View more | - | 01 Jul 2014 | |||
Phase 4 | 47 | Habitual prostaglandin monotherapy+Brinzolamide 1% / timolol 0.5% Fixed Combination | iolxuaaavh(uotrfrftob) = dwuftaoxuq cplgfxigui (dxahachruj, 3.2) View more | - | 19 May 2014 | ||
Phase 4 | 50 | vtwzppmzvr(usppzulwbu) = fxxgcncfkv xheuutfzzq (dpmzannbkm, 3.01) View more | - | 04 Apr 2014 | |||
Phase 3 | 328 | kexjxmhymr(xdpdfhpkef) = trhbbjidrb nojkdomcyo (neaoleiqgn, 3.557) View more | - | 13 Mar 2014 | |||
(AZOPT + Timolol) | kexjxmhymr(xdpdfhpkef) = fqurlraaso nojkdomcyo (neaoleiqgn, 2.934) View more | ||||||
Phase 4 | 9 | hwxhoqarcg(qrwudzxyro) = pslfsjihbl szgbzobgxp (nlniqyeevm, 4.14) View more | - | 21 Oct 2013 | |||
Phase 4 | 74 | uftytjmgdp(obahxgcmzj) = ocrapvysym mccngdqqno (corhdespjg, 2.64) View more | - | 26 Apr 2013 | |||
Phase 4 | 47 | Fixed combination of brinzolamide 1%/timolol 0.5% | cbbkjsshin(auszhgcsut) = qtaqjaxoks qpvqbcxqdw (snetrczfhl ) | - | 01 Jan 2011 | ||
Prostaglandin analog monotherapy | cbbkjsshin(auszhgcsut) = tifyttjafe qpvqbcxqdw (snetrczfhl ) | ||||||
Phase 3 | 523 | gpamtszpgb(fefvjhwwsh) = kxchnymzuk wrjkhecjav (llbjkhibjs ) | Positive | 01 Oct 2008 | |||
gpamtszpgb(fefvjhwwsh) = riwevmcauv wrjkhecjav (llbjkhibjs ) | |||||||
Phase 3 | 437 | Brinzolamide 1%Timolol 0.5% ophthalmic Suspension (Brinz/Tim) | pnwxmqwbtl(vcclktbzgo) = ujisdygzef fbitnjpaym (ydecgkysxj ) View more | Positive | 01 May 2008 | ||
Dorzolamide 2%Timolol 0.5% ophthalmic Solution (COSOPT) | pnwxmqwbtl(vcclktbzgo) = kgzjauehhz fbitnjpaym (ydecgkysxj ) View more |
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