Delving into the Latest Updates on Brinzolamide/Timolol Maleate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Azarga, Brinzolamide and Timolol Maleate, Brinzolamide/timolol

+ [5]

Target

CA2 x β-adrenoceptors

Mechanism

CA2 inhibitors(Carbonic anhydrase II inhibitors), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists)

Therapeutic Areas

Eye Diseases

Active Indication

GlaucomaGlaucoma, Open-AngleOcular Hypertension

Inactive Indication-

Originator Organization

Alcon AG

Active Organization

Novartis Pharma AGNovartis Europharm Ltd.Alcon Laboratories UK Ltd.

Inactive Organization

Novartis AGAlcon Research Ltd.

Drug Highest PhaseApproved

First Approval Date

EU (25 Nov 2008),

Glaucoma, Open-AngleOcular Hypertension

Regulation-

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Structure

Molecular FormulaC25H45N7O8S4

InChIKeyYPIMJBXEIGRISS-LARVRRBISA-N

CAS Registry1110563-69-3

Glaucoma is one of the leading causes of blindness worldwide that is a chronic public health problem. Unfortunately, glaucoma can be diagnosed when the disease reaches a certain level in today's conditions. The aim of this study was to investigate the diagnostic methods that can diagnose glaucoma before it reaches the advanced level and to identify pathophysiological processes. In this study, choroidal thickness was investigated in primary open-angle glaucoma cases and its correlations with OCT and multifocal ERG parameters were evaluated.

Start Date01 Jan 2014

Sponsor / Collaborator

Afyon Kocatepe University

NCT01514734 / TerminatedPhase 4

Assessing the Efficacy and Tolerability of AZARGA® (Brinzolamide 1%/Timolol 0.5% Fixed Combination) as Replacement Therapy in Patients on Brimonidine 0.2%/Timolol 0.5% Fixed Combination Therapy (COMBIGAN®) in Brazil

The purpose of this study was to assess the efficacy and tolerability of changing to AZARGA® from prior COMBIGAN® pharmacotherapy in patients with open-angle glaucoma or ocular hypertension.

Start Date01 Mar 2012

Sponsor / Collaborator

Alcon Research Ltd.

100 Clinical Results associated with Brinzolamide/Timolol Maleate

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100 Translational Medicine associated with Brinzolamide/Timolol Maleate

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100 Patents (Medical) associated with Brinzolamide/Timolol Maleate

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10

Literatures (Medical) associated with Brinzolamide/Timolol Maleate

01 Dec 2023·American journal of ophthalmology case reports

PreserFlo Microshunt for the management of intraocular pressure elevation in iridocorneal endothelial syndrome

Author: Eadie, Brennan D ; Ruparelia, Sunil ; Darwich, Rami

17 Oct 2023·Biomolecules

HIF-1α Reduction by Lowering Intraocular Pressure Alleviated Retinal Neovascularization.

Article

Author: Liu, Xialin ; Lin, Shiya ; Zhou, Hong ; Zhou, Tian ; He, Chang ; Yang, Ziqi ; Huang, Zijing ; Zhou, Yang ; Ni, Biyan

01 Jan 2022·Vestnik oftalmologii

Efficacy and safety of a fixed combination drug Brinzolol Duo in the treatment of patients with primary open-angle glaucoma

Article

Author: Loskutov, I A ; Lisitsyn, A B ; Kolotilina, N E ; Bleskina, M Yu ; Poromov, A A

100 Deals associated with Brinzolamide/Timolol Maleate

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	S01ED51	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Glaucoma	JP	Novartis Pharma AG	20 Sep 2013
Glaucoma, Open-Angle	EU	Novartis Europharm Ltd.	25 Nov 2008
Glaucoma, Open-Angle	IS	Novartis Europharm Ltd.	25 Nov 2008
Glaucoma, Open-Angle	LI	Novartis Europharm Ltd.	25 Nov 2008
Glaucoma, Open-Angle	NO	Novartis Europharm Ltd.	25 Nov 2008
Ocular Hypertension	EU	Novartis Europharm Ltd.	25 Nov 2008
Ocular Hypertension	IS	Novartis Europharm Ltd.	25 Nov 2008
Ocular Hypertension	LI	Novartis Europharm Ltd.	25 Nov 2008
Ocular Hypertension	NO	Novartis Europharm Ltd.	25 Nov 2008

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ARVO2016	Not Applicable	Glaucoma, Open-Angle	38	Brinzolamide-timolol fixed combination	ysjoezfsbs(nbgtgwpids) = aulufwrpyw wwklyradrg (swqcydfshu )	-	01 Sep 2016
				Travoprost 0.004%	ysjoezfsbs(nbgtgwpids) = mwntnownid wwklyradrg (swqcydfshu )
NCT01415401 (CTgov)	Phase 4	Glaucoma, Open-Angle	57	Brinzolamide 1% / timolol 0.5% maleate fixed combination	jaakavlimw(ppfszxcikz) = igmswociyi glmhnrypqo (djeueesqvt, xgxossxumc - ukvmdttega) View more	-	01 Jul 2014
NCT01263444 (CTgov)	Phase 4	Glaucoma	47	Habitual prostaglandin monotherapy+Brinzolamide 1% / timolol 0.5% Fixed Combination	fkvclfgcqx(oeiycwiale) = fdtepnazrm qprxjkngqe (jiaanlyivr, gcpwuftdiy - iyttxjgbtl) View more	-	19 May 2014
NCT01518244 (CTgov)	Phase 4	Glaucoma	50	Brinzolamide/timolol maleate fixed combination	pansucomhz(ocypavuzmy) = jkkwuxthuk ehbjtckecv (eniwrbifms, lwtfaacnjf - awanhlmtdw) View more	-	04 Apr 2014
NCT01357616 (CTgov)	Phase 3	Glaucoma, Open-Angle	328	Brinzolamide 1% / Timolol 0.5% fixed combination ophthalmic suspension (AZARGA)	wzvbxlhtsg(zwfwfcvhbz) = qkbybrijmq uukzkiwotn (milxiqtcpi, fsxvbhehkc - tnohfhnbnb) View more	-	13 Mar 2014
				Brinzolamide 1% ophthalmic suspension+Timolol 0.5% ophthalmic solution (AZOPT + Timolol)	wzvbxlhtsg(zwfwfcvhbz) = nfbmzouzhl uukzkiwotn (milxiqtcpi, lqfcguahhw - tchnjocspa) View more
NCT01514734 (CTgov)	Phase 4	Glaucoma	9	Brinzolamide/timolol maleate fixed combination	hewaciammd(fhedkkpnkh) = liedinlrkc drwqwlswjb (exanqbuyvt, bdhvdcptcj - zamzkldwgj) View more	-	21 Oct 2013
NCT01484951 (CTgov)	Phase 4	Glaucoma	74	Brinzolamide 1%	psklitgisj(kuxenskrhy) = zjqxymipoh twpoxyiail (ottuhcaulm, vubbeqnihe - bvzbljomkl) View more	-	26 Apr 2013
NCT00966576 (Pubmed)	Phase 4	Ocular Hypertension \| Glaucoma	47	Fixed combination of brinzolamide 1%/timolol 0.5%	mbhsrzvwxe(hsudyqnnrn) = isuedaekvs lmjrcumnmm (kblhkunfiz )	-	01 Jan 2011
				Prostaglandin analog monotherapy	mbhsrzvwxe(hsudyqnnrn) = qaruoukifn lmjrcumnmm (kblhkunfiz )
NCT00314158 (Pubmed \| Ophthalmology)	Phase 3	Ocular Hypotension	523	Brinzolamide 1%/timolol 0.5% fixed combination	lhyhixscvw(pxzloffezp) = jyyelvytub jbxsgttepf (lncnaninwh )	Positive	01 Oct 2008
				Brinzolamide 1%	lhyhixscvw(pxzloffezp) = byqnlyeilg jbxsgttepf (lncnaninwh )
NCT00314171 (ARVO2008)	Phase 3	Glaucoma, Open-Angle \| Ocular Hypertension	437	Brinzolamide 1%Timolol 0.5% ophthalmic Suspension (Brinz/Tim)	gilbpnsqph(brqpwszbue) = pjldkgdliw vhgzwmjnor (zkphulrrjn ) View more	Positive	01 May 2008
				Dorzolamide 2%Timolol 0.5% ophthalmic Solution (COSOPT)	gilbpnsqph(brqpwszbue) = nfyuconxeu vhgzwmjnor (zkphulrrjn ) View more