iStent Infinite and iDose TR for Management of Moderate to Severe Primary Open Angle Glaucoma Are a Safe and Effective Alternative to Filtering Surgery for IOP Reduction in Patients With Medically Uncontrolled Glaucoma. (POAG)

The Investigators will investigate the efficacy of combining the standalone iStent infinite and iDose that are minimally invasive surgical and drug depot options are a safe and effective alternative to filtering surgery for intraocuar pressure reduction in patients with medically uncontrolled open angle glaucoma.

Start Date05 Jan 2026

Sponsor / Collaborator

Wills Eye Institute

[+1]

NCT07400926

/ RecruitingNot Applicable

Clinical In-use Observational Trial to Evaluate the Updated Inserter for the Travoprost Intracameral Implant 75 mcg

Clinical in-use observational trial to evaluate the updated inserter for the Travoprost Intracameral implant using the updated inserter (Model G2-TRIO)

Start Date17 Dec 2025

Sponsor / Collaborator

Glaukos Corp.

100 Clinical Results associated with Travoprost

100 Translational Medicine associated with Travoprost

100 Patents (Medical) associated with Travoprost

788

Literatures (Medical) associated with Travoprost

01 Jul 2026·EYE

Regional variation and trends in prostaglandin analogue prescribing for glaucoma in England 2019–2024

Article

Author: Robinson, David Grant ; Whitaker, Angela

Abstract:

Background:

Prescribing for glaucoma drops constitutes a large proportion of the NHS medicines budget for ophthalmology. NICE guidelines direct clinicians towards the prescription of a generic prostaglandin analogue (PGA) as a first-line topical hypotensive for lowering intraocular pressure. Between 2009 and 2018 the cost-effectivity of PGA prescribing at a national level in England was questionable. This study aimed to examine the variation and trends of PGA prescription at a regional level from 2019 to 2024.

Methods:

Using an online open-access source, monthly data relating to General Practitioner prescription of latanoprost, bimatoprost, travoprost and tafluprost were collected. Data gathered related to PGA prescription activity from each of the individual Clinical Commissioning Groups (CCGs) in England. Descriptive statistics and choropleth maps were produced to display outcomes.

Results:

Total PGA prescribing cost over 5 years was £166 M for 21.9 M prescriptions. A broad trend towards generic prescribing was identified. Branded and preservative free prescribing, in preference to a generic equivalent, resulted in an additional cost of approximately £54 M. Latanoprost was most readily prescribed in the South West and South East regions. Bimatoprost and travoprost were prescribed more in the North East and the East of England respectively.

Conclusions:

Regional variation in PGA prescribing exists in England. Further investigation is required to determine the primary cause for the reported differences. Reducing variations so that prescribing clinicians are directed towards the most cost-effective PGA choice has the potential for considerable cost savings to NHS budgets.

01 Apr 2026·Ophthalmology and Therapy

Safety and Feasibility of the Exchange Procedure for the Travoprost Intracameral Implant for Open-Angle Glaucoma or Ocular Hypertension

Article

Author: Katz, L Jay ; Sarkisian, Steven R ; Applegate, David ; Kothe, Angela C ; Navratil, Tomas ; Lehmann, Robert P ; Jones, Jason J ; Berdahl, John P

INTRODUCTION:

We conducted a prospective, single-arm, open-label study to evaluate the feasibility and safety of an exchange procedure for the travoprost intracameral implant.

METHODS:

Adult subjects with open-angle glaucoma or ocular hypertension who had previously received a travoprost intracameral implant were enrolled at 12 sites in the United States and one in the Philippines. Subjects were administered a new travoprost intracameral implant followed by removal of the previous implant ("exchange" procedure). The primary outcome measures were treatment-emergent adverse events, and other ocular safety parameters (i.e., endothelial cell density, visual acuity, slit-lamp biomicroscopy, and visual fields).

RESULTS:

Thirty-three subjects who had received a travoprost intracameral implant for a mean duration of 4.2 years prior were recruited. All subjects were successfully implanted with a new implant, and the previous implant was successfully removed. There were no treatment-related serious adverse events, or severe treatment-related adverse events in the eye that underwent the exchange procedure. No subject required a subsequent explantation.

CONCLUSIONS:

Travoprost intracameral implant demonstrated an acceptable safety profile both during and after the exchange procedure, supporting its re-administration.

CLINICALTRIALS:

gov NCT04615403.

01 Feb 2026·DRUGS & AGING

Implants to Treat Glaucoma: Promising or Not?

Review

Author: Kolko, Miriam ; Cvenkel, Barbara

Glaucoma is one of the leading causes of blindness and its prevalence increases with age. The most common form, primary open-angle glaucoma, is a chronic, slowly progressive optic neuropathy characterised by the loss of retinal ganglion cells and their axons, leading to irreversible visual field loss. Elevated intraocular pressure (IOP) is the only modifiable risk factor for glaucoma. Reducing IOP to a level that is safe for the patient's eye has been shown to slow disease progression. Lowering IOP in open-angle glaucoma is achieved by eye drops, selective laser trabeculoplasty (SLT) and/or surgery. Many patients are treated with IOP-lowering eye drops, which require lifelong continuous instillation. However, as with other chronic, asymptomatic diseases, adherence to glaucoma treatment is poor for various reasons and is associated with faster disease progression. The purpose of this review is to discuss several sustained-release systems that have been investigated to reduce IOP over time, to address barriers to adherence and improve quality of life. Among these, non-invasive drug-eluting delivery systems such as contact lenses, punctal plugs, and conjunctival ocular inserts have not reached the market. Currently, only two intracameral implants have been approved by the Food and Drug Administration for single use due to corneal safety issues. The biodegradable bimatoprost implant releases the drug continuously for 4-6 months, and its effect on IOP may extend for up to 2 years in 25% of patients. The non-biodegradable intracameral implant releases travoprost for 36 months, when it needs to be removed. However, additional data are needed to assess safety following repeated administration, as well as in broader patient populations and in combination with other treatment approaches such as SLT. Several other biodegradable intracameral implants that release prostaglandin analogues are undergoing clinical trials. In the future, intraocular implants containing genetically modified cells that secrete neurotrophic factors may potentially offer an IOP-independent neuroprotective strategy, complementing existing IOP-lowering implants in glaucoma management.

167

News (Medical) associated with Travoprost

01 Sep 2026

·www.globenewswire.com

Ocular Therapeutix™ to Participate in September and October Investor and Scientific Conferences

BEDFORD, Mass., Sept. 01, 2026 (GLOBE NEWSWIRE) -- Ocular Therapeutix, Inc. (NASDAQ: OCUL, “Ocular”), an integrated biopharmaceutical company committed to redefining the retina experience, today announced participation in several upcoming investor and scientific conferences in September and October 2026. Upcoming Investor Conferences: Wells Fargo 21st Annual Healthcare Conference:Date: Thursday, September 10, 2026Ocular Therapeutix to host investor one-on-one meetingsLocation: Boston, MA Baird 2026 Global Healthcare Conference:Date: Tuesday, September 15, 2026Fireside Chat: 10:50 – 11:20 AM EDTPresenter: Pravin U. Dugel, MD, Executive Chairman, President and CEOLocation: New York, NY A live webcast of the Baird fireside chat can be accessed by visiting the Ocular Therapeutix website on the Events and Presentations section of the Investor Relations page. A replay of the webcasts will be archived for at least 30 days following the presentation. Upcoming Scientific Conferences: The Retina Society 59th Annual Scientific Meeting: September 23 – 26, 2026Los Angeles, CA Presentation: Efficacy and Safety of Intravitreal Axitinib Hydrogel (OTX-TKI) in Neovascular Age-related Macular Degeneration: Results from the Phase 3 SOL-1 Superiority TrialSession: AMD IPresentation Date/Time: Thursday, September 24, 2026, 11:30 – 11:34 AM PDTPresenter: Dilsher S. Dhoot, MD Ophthalmology Futures Forums (OFF) Retina Forum 2026: September 30, 2026Vienna, Austria Presentation: Ocular Therapeutix: Redefining the Retina ExperiencePresenter: Nadia K. Waheed, MD, MPH, Chief Medical Officer, Ocular Therapeutix Euretina Innovation Spotlight (EIS): September 30, 2026Vienna, Austria Presentation Title: Ocular Therapeutix: Redefining the Retina Experience Presenter: Peter K. Kaiser, MD, Chief Development Officer, Ocular Therapeutix 26th Euretina Congress: October 1 - 4, 2026Vienna, Austria Presentation Title: Efficacy and Safety of Intravitreal Axitinib Hydrogel (OTX-TKI) in Neovascular Age-related Macular Degeneration: Results from the Phase 3 SOL-1 Superiority Trial Session: AMD/CSCSession Date/Time: Friday, October 2, 2026, 13:24 – 13:30 PM CESTPresenter: Adnan Tufail, MBBS, MD, FRCOphth Symposium Title: Redefining the Management of nAMD: The Impact of Durability and Sustained Disease ControlSymposium Date/Time: Friday, October 2, 2026, 9:45 – 10:45 AM CESTFaculty: Arshad M. Khanani, MD, MA, FASRS; Patricio G. Schlottmann, MD; Adnan Tufail, MBBS, MD, FRCOphth; Dilsher S. Dhoot, MD Exact medical conference presentation times may be subject to change. About Ocular Therapeutix, Inc.Ocular Therapeutix, Inc. is an integrated biopharmaceutical company committed to redefining the retina experience. AXPAXLI™ (also known as OTX-TKI), Ocular’s investigational product candidate for retinal disease, is an axitinib intravitreal hydrogel based on its ELUTYX™ proprietary bioresorbable hydrogel-based formulation technology. AXPAXLI is currently in Phase 3 clinical trials for wet age-related macular degeneration (wet AMD), and diabetic retinal disease, including non-proliferative diabetic retinopathy (NPDR). Ocular’s pipeline also leverages the ELUTYX technology in its commercial product DEXTENZA®, an FDA-approved corticosteroid for the treatment of ocular inflammation and pain following ophthalmic surgery in adults and pediatric patients and ocular itching associated with allergic conjunctivitis in adults and pediatric patients aged two years or older, and in its investigational product candidate OTX-TIC, which is a travoprost intracameral hydrogel that has completed a Phase 2 clinical trial for the treatment of open-angle glaucoma or ocular hypertension. Ocular is currently evaluating next steps for the OTX-TIC program. Follow the Company on its website, LinkedIn, or X. DEXTENZA® is a registered trademark of Ocular Therapeutix, Inc. The Ocular Therapeutix logo, AXPAXLI™, ELUTYX™, and Ocular Therapeutix™ are trademarks of Ocular Therapeutix, Inc. Investors & MediaOcular Therapeutix, Inc.Bill SlatteryVice President, Investor Relationsbslattery@ocutx.com

01 Sep 2026

·www.biospace.com

Ocular Therapeutix™ to Participate in September and October 2026 Investor and Scientific Conferences

BEDFORD, Mass., Sept. 01, 2026 (GLOBE NEWSWIRE) -- Ocular Therapeutix, Inc. (NASDAQ: OCUL, “Ocular”), an integrated biopharmaceutical company committed to redefining the retina experience, today announced participation in several upcoming investor and scientific conferences in September and October 2026. Upcoming Investor Conferences : Wells Fargo 21 st Annual Healthcare Conference : Date: Thursday, September 10, 2026 Ocular Therapeutix to host investor one-on-one meetings Location: Boston, MA Baird 2026 Global Healthcare Conference : Date: Tuesday, September 15, 2026 Fireside Chat: 10:50 – 11:20 AM EDT Presenter: Pravin U. Dugel, MD, Executive Chairman, President and CEO Location: New York, NY A live webcast of the Baird fireside chat can be accessed by visiting the Ocular Therapeutix website on the Events and Presentations section of the Investor Relations page. A replay of the webcasts will be archived for at least 30 days following the presentation. Upcoming Scientific Conferences : The Retina Society 59 th Annual Scientific Meeting: September 23 – 26, 2026 Los Angeles, CA Presentation: Efficacy and Safety of Intravitreal Axitinib Hydrogel (OTX-TKI) in Neovascular Age-related Macular Degeneration: Results from the Phase 3 SOL-1 Superiority Trial Session: AMD I Presentation Date/Time: Thursday, September 24, 2026, 11:30 – 11:34 AM PDT Presenter: Dilsher S. Dhoot, MD Ophthalmology Futures Forums (OFF) Retina Forum 2026 : September 30, 2026 Vienna, Austria Presentation: Ocular Therapeutix: Redefining the Retina Experience Presenter: Nadia K. Waheed, MD, MPH, Chief Medical Officer, Ocular Therapeutix Euretina Innovation Spotlight (EIS) : September 30, 2026 Vienna, Austria Presentation Title: Ocular Therapeutix: Redefining the Retina Experience Presenter: Peter K. Kaiser, MD, Chief Development Officer, Ocular Therapeutix 26 th Euretina Congress : October 1 - 4, 2026 Vienna, Austria Presentation Title: Efficacy and Safety of Intravitreal Axitinib Hydrogel (OTX-TKI) in Neovascular Age-related Macular Degeneration: Results from the Phase 3 SOL-1 Superiority Trial Session: AMD/CSC Session Date/Time: Friday, October 2, 2026, 13:24 – 13:30 PM CEST Presenter: Adnan Tufail, MBBS, MD, FRCOphth Symposium Title: Redefining the Management of nAMD: The Impact of Durability and Sustained Disease Control Symposium Date/Time: Friday, October 2, 2026, 9:45 – 10:45 AM CEST Faculty: Arshad M. Khanani, MD, MA, FASRS; Patricio G. Schlottmann, MD; Adnan Tufail, MBBS, MD, FRCOphth; Dilsher S. Dhoot, MD Exact medical conference presentation times may be subject to change. About Ocular Therapeutix, Inc. Ocular Therapeutix, Inc. is an integrated biopharmaceutical company committed to redefining the retina experience. AXPAXLI™ (also known as OTX-TKI), Ocular’s investigational product candidate for retinal disease, is an axitinib intravitreal hydrogel based on its ELUTYX™ proprietary bioresorbable hydrogel-based formulation technology. AXPAXLI is currently in Phase 3 clinical trials for wet age-related macular degeneration (wet AMD), and diabetic retinal disease, including non-proliferative diabetic retinopathy (NPDR). Ocular’s pipeline also leverages the ELUTYX technology in its commercial product DEXTENZA ® , an FDA-approved corticosteroid for the treatment of ocular inflammation and pain following ophthalmic surgery in adults and pediatric patients and ocular itching associated with allergic conjunctivitis in adults and pediatric patients aged two years or older, and in its investigational product candidate OTX-TIC, which is a travoprost intracameral hydrogel that has completed a Phase 2 clinical trial for the treatment of open-angle glaucoma or ocular hypertension. Ocular is currently evaluating next steps for the OTX-TIC program. Follow the Company on its website, LinkedIn, or X. DEXTENZA ® is a registered trademark of Ocular Therapeutix, Inc. The Ocular Therapeutix logo, AXPAXLI™, ELUTYX™, and Ocular Therapeutix™ are trademarks of Ocular Therapeutix, Inc. Investors & Media Ocular Therapeutix, Inc. Bill Slattery Vice President, Investor Relations bslattery@ocutx.com

Phase 3

13 Aug 2026

·www.biospace.com

Ocular Therapeutix™ Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) - August 13, 2026

BEDFORD, Mass., Aug. 13, 2026 (GLOBE NEWSWIRE) -- Ocular Therapeutix, Inc. (NASDAQ: OCUL, “Ocular” or the “Company”), an integrated biopharmaceutical company committed to redefining the retina experience, today announced that it has granted inducement awards to Ms. Beth Rada, the Company’s new SVP, Government Affairs and Public Policy. The awards were made as an inducement material to the recipient’s acceptance of employment with Ocular under Ocular’s 2019 Inducement Stock Incentive Plan in accordance with Nasdaq Listing Rule 5635(c)(4). The inducement equity awards granted to Ms. Rada were effective as of August 10, 2026 and consist of a non-statutory stock option award to purchase up to 85,000 shares of Ocular’s common stock and restricted stock unit awards representing the right to receive an aggregate of 28,000 shares of Ocular’s common stock. Ms. Rada’s stock option award has an exercise price of $9.24 per share, equal to the closing price of Ocular’s common stock on The Nasdaq Global Market on the effective date of grant. The stock option award has a ten-year term and vests over four years, with 25% of the original number of shares vesting on the one-year anniversary of the date of grant, and the remainder vesting in equal monthly installments over the three years after such date, subject to the recipient’s continued service to Ocular through the applicable vesting dates. The restricted stock unit awards vest over three years, in equal annual installments on the first, second and third anniversaries of the date of grant, subject to the recipient’s continued service to Ocular through the applicable vesting dates. The inducement equity awards are subject to the terms and conditions of the award agreements covering the grants and Ocular’s 2019 Inducement Stock Incentive Plan. About Ocular Therapeutix, Inc. Ocular Therapeutix, Inc. is an integrated biopharmaceutical company committed to redefining the retina experience. AXPAXLI™ (also known as OTX-TKI), Ocular’s investigational product candidate for retinal disease, is an axitinib intravitreal hydrogel based on its ELUTYX™ proprietary bioresorbable hydrogel-based formulation technology. AXPAXLI is currently in Phase 3 clinical trials for wet age-related macular degeneration (wet AMD), and diabetic retinal disease, including non-proliferative diabetic retinopathy (NPDR). Ocular’s pipeline also leverages the ELUTYX technology in its commercial product DEXTENZA ® , an FDA-approved corticosteroid for the treatment of ocular inflammation and pain following ophthalmic surgery in adults and pediatric patients and ocular itching associated with allergic conjunctivitis in adults and pediatric patients aged two years or older, and in its investigational product candidate OTX-TIC, which is a travoprost intracameral hydrogel that has completed a Phase 2 clinical trial for the treatment of open-angle glaucoma or ocular hypertension. Ocular is currently evaluating next steps for the OTX-TIC program. Follow the Company on its website, LinkedIn, or X. DEXTENZA ® is a registered trademark of Ocular Therapeutix, Inc. The Ocular Therapeutix logo, AXPAXLI™, ELUTYX™, and Ocular Therapeutix™ are trademarks of Ocular Therapeutix, Inc. Investors & Media Ocular Therapeutix, Inc. Bill Slattery Vice President, Investor Relations bslattery@ocutx.com

Phase 3Phase 2Drug Approval

100 Deals associated with Travoprost

External Link

KEGG	Wiki	ATC	Drug Bank
D01964	Travoprost	S01EE04	DB00287

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Glaucoma	Japan	Novartis Pharmaceuticals Corp.	31 Jul 2007
Glaucoma, Open-Angle	United States	Alcon Pharmaceuticals Ltd.	16 Mar 2001
Ocular Hypertension	United States	Alcon Pharmaceuticals Ltd.	16 Mar 2001

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Hypertension	NDA/BLA	United States	Glaukos Corp.	05 May 2023
Glaucoma-Related Pigment Dispersion Syndrome	Phase 3	-	Alcon Research Ltd.	01 Nov 2011
Glaucoma, Angle-Closure	Phase 3	United States	Alcon Research Ltd.	01 Jan 2000
Glaucoma, Angle-Closure	Phase 3	Australia	Alcon Research Ltd.	01 Jan 2000
Exfoliation Syndrome	Clinical	United States	Alcon Research Ltd.	01 Sep 2003

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05335122 (CTgov)	Phase 2	Ocular Hypertension \| Glaucoma, Open-Angle \| Glaucoma	83	Bimatoprost	ozwbxbtrve(ffwganenqh) = myheenjvkh bcziubwsbk (gojpcaevkx, 3.567) View more	-	03 Sep 2026
ARVO2026	Not Applicable	Glaucoma, Open-Angle	40	bimatoprost	hrtkibivdc(ilwtylexdo) = lcbuowedaq yemufggznb (fpzjriydfd ) View more	Negative	03 May 2026
NCT06582732 (Pubmed \| Ophthalmol Ther)	Phase 2	Glaucoma, Open-Angle	210	Travoprost Intracameral Implant	lzkviqxufp(urtmkymtah) = golvgndqdr wydhmkpyzo (oohdtvushd )	Positive	24 Mar 2025
NCT06061718 (Pubmed \| Ther Adv Ophthalmol)	Phase 3	Ophthalmologic surgical procedures	60	Travoprost intracameral implant + Cataract surgery	klsbwsukch(etinhkqkff) = Study eye adverse events were reported in 8.3% of patients qpshsvwvjc (tkajabzjum ) View more	Positive	01 Jan 2025
NCT06582732 (CTgov)	Phase 2	Glaucoma, Open-Angle	210	Travoprost Intracameral Implant exchanged at Month 12 (Cohort 1 (12-month Exchange))	huesjfrkkk(immwpxmpce) = nptfgkiwzn kmjmrhfgln (kotnadeves, 3.02) View more	-	15 Oct 2024
				Travoprost Intracameral Implant exchanged at Month 3 (Cohort 2 (3-month Exchange))	qejtyvzekn(uoguhxokht) = njzbjbadqr yfrtjxudsv (gkyqtfioqu, 2.50) View more
NCT04360174 (CTgov)	Phase 1	Ocular Hypertension \| Glaucoma, Open-Angle	19	OTX-TIC (OTX-TIC-Cohort 1)	idcgokpchv = mbshhdzpuz xpaecfmmyr (sflhjgjpnp, cgmbfbvqvm - syhgoflbpl) View more	-	01 Oct 2024
				OTX-TIC (OTX-TIC-Cohort 2)	idcgokpchv = pruhmibijc xpaecfmmyr (sflhjgjpnp, xykqitomve - gckrzmndub) View more
NCT03519386 \| NCT03868124 (Pubmed)	Phase 3	Glaucoma, Open-Angle \| Ocular Hypertension	133	Travoprost Intracameral Implant	wnhnwlpkio(dojxjpecux) = lqaiijdzgy xdwpvgqlix (tvrinmbaic )	Positive	10 Jul 2024
				Topical Prostaglandin Analog	wnhnwlpkio(dojxjpecux) = czkdwrnafz xdwpvgqlix (tvrinmbaic )
NCT05335122 (GlobeNewswire) Manual	Phase 2	Glaucoma, Open-Angle	-	26 µg of PAXTRAVA	zaxpnebcqm(sapkaifrsn) = vnvjbykopg gijzvndrkr (krluigfkmz )	Positive	06 Apr 2024
				DURYSTA	-
NCT03519386 (Pubmed \| Ophthalmol Ther)	Phase 3	Ocular Hypertension \| Glaucoma, Open-Angle	590	Travoprost intracameral SE-implant	fuuclktxzh(guivufxlhe) = nuguwikoja zufkscosky (ghtlpreoou, < 1.5 mmHg at all six timepoints and < 1 mmHg at three or more timepoints)	Positive	01 Apr 2024
				Travoprost intracameral FE-implant	fuuclktxzh(guivufxlhe) = rvitmzdvxa zufkscosky (ghtlpreoou, < 1.5 mmHg at all six timepoints and < 1 mmHg at three or more timepoints)
NCT02754596 (Pubmed \| Drugs)	Phase 2	Ocular Hypertension \| Glaucoma, Open-Angle	-	Fast-eluting implant (FE implant)	oyaovabkmp(xlxdncdxqg) = bxsdxtcanu oowfusiksz (cfnvkkrtnf )	Positive	01 Jan 2024
				Slow-eluting implant (SE implant)	oyaovabkmp(xlxdncdxqg) = msbpildnkl oowfusiksz (cfnvkkrtnf )

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