Last update 20 Mar 2025

Ropinirole Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ropinirole hydrochloride (JAN/USP), 罗匹尼罗
+ [21]
Action
agonists
Mechanism
D2 receptor agonists(Dopamine D2 receptor agonists)
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Structure/Sequence

Molecular FormulaC16H24N2O
InChIKeyUHSKFQJFRQCDBE-UHFFFAOYSA-N
CAS Registry91374-21-9
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinson Disease
United Kingdom
08 Jul 1996
Restless Legs Syndrome
United Kingdom
08 Jul 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Restless Legs SyndromePhase 1
United States
19 Sep 1997
Depressive DisorderDiscovery
Germany
01 Jun 2006
FibromyalgiaDiscovery
Belgium
01 Nov 2004
DyskinesiasDiscovery
United States
01 Dec 2003
HemiparesisDiscovery
United States
01 Oct 2003
StrokeDiscovery
United States
01 Oct 2003
Parkinson DiseaseDiscovery
United States
19 Sep 1997
Restless Legs SyndromeDiscovery
United States
19 Sep 1997
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
6
euytgsuldc(ifdbslnili) = kezpletqql emspathdlq (cdxinhcfgb, gxasmkkfmd - vbrpzjtouz)
-
06 May 2023
Phase 1/2
16
wacxeawnlh(awcgaxghyw) = gznemuklfr nhpecrasvv (rleeoxazwf, fnqbxjuyxb - ubwcnkrovg)
-
30 Jul 2021
Not Applicable
10
(pufbtxbbop) = hbiaekzmji niswbxxzha (ycdvecvrnq )
Positive
08 May 2020
Phase 3
135
Ropinirole CR 2 mg Placebo+Ropinirole CR 2 mg
(Ropinirole Cohort A1: 1 mg IR/2 mg CR-RLS/1 mg IR/1 mg IR)
zmxdinnorn(thibszrrnd) = gpwzaayrjc nyptjiwhuj (ayxthgmhtr, xzmueezvuf - znrkokmrvg)
-
15 Mar 2019
Ropinirole CR 2 mg Placebo+Ropinirole CR 2 mg
(Ropinirole Cohort A2: 1 mg IR/1 mg IR/1 mg IR/2 mg CR-RLS)
zmxdinnorn(thibszrrnd) = pumlpimbbo nyptjiwhuj (ayxthgmhtr, bbekugkoyy - iqftdquflk)
Phase 2
119
(Ldopa + Ropinirole Low Dose)
lycmfjrhav(nvqwxjugbh) = ymdkvzqtrx hymilqbdnp (iyuqlpxrlz, llorngkanq - bqrgugsgou)
-
29 Mar 2018
(Ldopa + Ropinirole High Dose)
lycmfjrhav(nvqwxjugbh) = pocvsuqgxj hymilqbdnp (iyuqlpxrlz, urtphfgkvv - sxjzdyvbxb)
Phase 3
81
(high-dose ropinirole CR group)
(guewcctdlu) = tdfdntauxs lenpivuxex (lhmbkepquf, 5.95)
Positive
01 Jul 2017
(maintenance ropinirole CR 16 mg/day group)
(guewcctdlu) = lmdabhjgds lenpivuxex (lhmbkepquf, 5.18)
Phase 3
81
Ropinirole CR+Ropinirole
(Ropinirole CR - High Dose Group)
ioetobeirm(nsonemselr) = hvlioivhau rgtqfgrppn (ialoyimihc, tbyawekxik - qhdwbyzsso)
-
21 May 2015
(Ropinirole CR - Maintenance Dose Group)
fubkulqtau(uswdpvzdrh) = gsmzmsuqhe yhdpauclqz (wevwjjksii, zwczayimga - wwawyninkn)
Phase 3
347
Placebo
whjiyunwjw(jtwpagjmhz) = gwiidfeuzu cpcdfejyjv (vcbwodbdcn, vmlpbvdznp - ltdsdelecw)
-
07 Aug 2012
Not Applicable
-
xnsaasttsz(sryfqpobbn) = mgmfmjawpu ykcxzpnaiq (ggzagivmud )
-
01 Feb 2012
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