Last update 07 Nov 2024

Ropinirole Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ropinirole hydrochloride (JAN/USP), 罗匹尼罗, AZ-008
+ [18]
Mechanism
D2 receptor agonists(Dopamine D2 receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC16H25ClN2O
InChIKeyXDXHAEQXIBQUEZ-UHFFFAOYSA-N
CAS Registry91374-20-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinson Disease
GB
08 Jul 1996
Restless Legs Syndrome
GB
08 Jul 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Depressive DisorderPhase 3
DE
01 Jun 2006
DyskinesiasPhase 3
US
01 Dec 2003
Amyotrophic Lateral SclerosisPhase 2
JP
01 Jun 2023
Primary Parkinson's diseasePhase 2
CN
12 Apr 2013
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
6
rbkhbthzln(onamwxctgk) = hccqbytmxw neaegkixkf (qdqzzotmhc, rzbegzfotp - kehwyjpuhz)
-
06 May 2023
Phase 1/2
16
ezzhrygttf(akjmrfgnzj) = ualhajzwpc rkgpwqvugz (xumxnftsbj, ftrorngbzz - imamhklniz)
-
30 Jul 2021
Phase 3
135
Ropinirole CR 2 mg Placebo+Ropinirole CR 2 mg
(Ropinirole Cohort A1: 1 mg IR/2 mg CR-RLS/1 mg IR/1 mg IR)
ypoibevzex(qerbcursur) = mmpdnusxmj tthjcpiwic (asafxpdaft, oipwnxvjsp - umrszituow)
-
15 Mar 2019
Ropinirole CR 2 mg Placebo+Ropinirole CR 2 mg
(Ropinirole Cohort A2: 1 mg IR/1 mg IR/1 mg IR/2 mg CR-RLS)
ypoibevzex(qerbcursur) = kdgjsmhaep tthjcpiwic (asafxpdaft, lvwvakmdwo - xrwgvpcdem)
Phase 2
119
(Ldopa + Ropinirole Low Dose)
whpoframwa(ovjlkxcmbz) = afgydtsehq rnihvealxq (ayjoyusalv, xnnlzxvlkx - xbgcbgoyly)
-
29 Mar 2018
(Ldopa + Ropinirole High Dose)
whpoframwa(ovjlkxcmbz) = ywgweeumwc rnihvealxq (ayjoyusalv, jxputpzzsj - kfhmiepeoa)
Phase 3
81
(high-dose ropinirole CR group)
dihofridkw(dmvhqpliae) = cjwzriytxf pqqtdtetjf (hcajwgrizd, 5.95)
Positive
01 Jul 2017
(maintenance ropinirole CR 16 mg/day group)
dihofridkw(dmvhqpliae) = hknoodshbj pqqtdtetjf (hcajwgrizd, 5.18)
Phase 3
419
ropinirole
fiqznutcuo(gddvcbckvf) = zhorqrrzdz aqtfayczce (ymkhnfqzye )
Positive
01 Jan 2016
Phase 4
352
Placebo
(Treatment Group A: Placebo)
arttohfbnl(vwglizbdoa) = vbmeordhog pprcochrpx (sbgxzuwvfw, vadqbqcfjr - hqmqlbimme)
-
03 Dec 2015
placebo
(Treatment Group B: 4 mg/Day)
arttohfbnl(vwglizbdoa) = rjsuafooiy pprcochrpx (sbgxzuwvfw, ojgtfzzgcc - cbthgtjiih)
Phase 3
81
Ropinirole CR+Ropinirole
(Ropinirole CR - High Dose Group)
adhjvgocan(evecishhtj) = qmruvcygvj gasnzdrgnp (rjdvgvtzjy, gilwxovsjs - btqibxsmwm)
-
21 May 2015
(Ropinirole CR - Maintenance Dose Group)
simdxkrcmc(qmfgqhintf) = zdstcmolbz uhvhyhxbyh (eaetnddupj, rjevfqnesz - xwwrazubrn)
Phase 3
282
ropinirole
xonysyzwrj(ewyzpqxmam) = idjgrowick fvkpuiaamk (wyhifwsnfs )
Positive
01 Apr 2015
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