Last update 18 Dec 2024

Carbidopa/Levodopa

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AP-CD/LD, AP-CDLD, Carbidopa and Levodopa
+ [62]
Mechanism
DDC inhibitors(DOPA decarboxylase inhibitors), DRDs antagonists(Dopamine receptors antagonists)
Originator Organization
Drug Highest PhaseApproved
RegulationFast Track (US), Orphan Drug (US)
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External Link

KEGGWikiATCDrug Bank
-Carbidopa/Levodopa-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinsonian Disorders
JP
14 May 1993
Parkinson Disease
US
02 May 1975
Parkinson Disease, Postencephalitic
US
02 May 1975
Parkinson Disease, Secondary
US
02 May 1975
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
DyskinesiasPhase 3
US
09 Feb 2017
DyskinesiasPhase 3
FI
09 Feb 2017
DyskinesiasPhase 3
GR
09 Feb 2017
DyskinesiasPhase 3
HU
09 Feb 2017
DyskinesiasPhase 3
IT
09 Feb 2017
DyskinesiasPhase 3
SK
09 Feb 2017
DyskinesiasPhase 3
ES
09 Feb 2017
Neuroleptic Malignant SyndromePhase 3
US
26 Oct 2015
Neuroleptic Malignant SyndromePhase 3
AU
26 Oct 2015
Neuroleptic Malignant SyndromePhase 3
CA
26 Oct 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
141
Oral IR carbidopa-levodopa
orzevvevkn(avbmhbxrek) = rxcpgrvmyr cxjxauspzm (cjhsbezngn, 0.50)
Positive
16 Oct 2024
orzevvevkn(avbmhbxrek) = msvhhgnyij cxjxauspzm (cjhsbezngn, 0.52)
Phase 3
-
xinxeihkkv(qakzqnyzgk) = wpsdywhxyq rbwbnhopuu (jqalovdprt )
Positive
30 Sep 2024
Phase 3
630
jzpaoabuqs(lqxefsmepx) = bnknsjoksq wefsnmdiqy (rtgtnpcbzk )
Positive
07 Aug 2024
Immediate-release carbidopa-levodopa
jzpaoabuqs(lqxefsmepx) = spkgpsicft wefsnmdiqy (rtgtnpcbzk )
Not Applicable
-
tobgaqqwfq(nnmowbngdf) = Most (88.1%) cases of infusion site infection were mild-­severity, with a median time to resolution of 15 days. Infusion site infection led to discontinuation in only 12 (2.9%) patients. dzwjqlnmax (nqacuqwqvj )
-
28 Jun 2024
Not Applicable
-
24-hour ND0612 infusion
rzwkhcvybf(iqbhlprsbv) = ehwuiwgaqx mcjpxuwdls (nwcabebmow )
-
09 Apr 2024
Phase 3
381
tlydhqdtdc(trrbzdsqgm) = gupblavngx ikwtzuojzt (wefcofmhnq, –0.94 - –0.02)
Met
Positive
15 Mar 2024
levodopa+carbidopa
tlydhqdtdc(trrbzdsqgm) = pxrjucgjxt ikwtzuojzt (wefcofmhnq, –2.65 - –1.74)
Met
Phase 3
244
(ABBV-951 Low Dose Subgroup)
dzyfckqxyt(syiokbcqxy) = uqcexccbvo qpmygispcl (yzleubvbfw, cllvydroep - qlztkwscwe)
-
23 Oct 2023
(ABBV-951 High Dose Subgroup)
dzyfckqxyt(syiokbcqxy) = tppcpsfvrz qpmygispcl (yzleubvbfw, awvlmqxuah - tpxvogdchr)
Phase 3
-
cwrbvswycy(wntruigzgp) = hudvkvcrnx pthhapkahw (pycavhoelf )
Met
Positive
29 Aug 2023
otcfojqyaj(twxykdjayn) = blncqgucpg vnpfjvkwpv (oksjljdmzb )
Phase 2
214
exjxgtnvbr(jdjphjdatf) = wbcrpjdilm vnsibmckcj (cxxxckssxx )
Positive
27 Aug 2023
Phase 2
114
ghcpivtnbk(gkpxtsiqnp) = n=4 in Year 2 and n=10 in Year 3 htqpsuvlzw (ucdiamreqp )
-
27 Aug 2023
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