Drug Type Small molecule drug |
Synonyms AP-CD/LD, AP-CDLD, Carbidopa and Levodopa + [67] |
Target |
Action inhibitors, antagonists |
Mechanism DDC inhibitors(DOPA decarboxylase inhibitors), DRDs antagonists(Dopamine receptors antagonists) |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (02 May 1975), |
RegulationFast Track (United States), Orphan Drug (United States) |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Carbidopa/Levodopa | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Parkinsonian Disorders | Japan | 14 May 1993 | |
Parkinson Disease | United States | 02 May 1975 | |
Parkinson Disease, Postencephalitic | United States | 02 May 1975 | |
Parkinson Disease, Secondary | United States | 02 May 1975 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Dyskinesias | Phase 3 | United States | 09 Feb 2017 | |
Dyskinesias | Phase 3 | Finland | 09 Feb 2017 | |
Dyskinesias | Phase 3 | Greece | 09 Feb 2017 | |
Dyskinesias | Phase 3 | Hungary | 09 Feb 2017 | |
Dyskinesias | Phase 3 | Italy | 09 Feb 2017 | |
Dyskinesias | Phase 3 | Slovakia | 09 Feb 2017 | |
Dyskinesias | Phase 3 | Spain | 09 Feb 2017 | |
Neuroleptic Malignant Syndrome | Phase 3 | United States | 26 Oct 2015 | |
Neuroleptic Malignant Syndrome | Phase 3 | Australia | 26 Oct 2015 | |
Neuroleptic Malignant Syndrome | Phase 3 | Canada | 26 Oct 2015 |
Phase 4 | 19 | (Experiment 1: Primary Outcomes (MDS-UPDRS, Joystick Task, Tapping Speed)) | bcxoppaepp(xnthdcmhwx) = tediftczyn vpbymmfmnm (bhyhdazvrz, 23.12) View more | - | 18 Jul 2025 | ||
(Experiment 2: Primary Outcome (Value Driven Attentional Oculomotor Capture)) | kduxbhcgmd(meqwsphyfy) = djkzpwhbuw jygjboduak (axeerjmdbs, 0.09) View more | ||||||
Phase 1/2 | 13 | (Carbidopa Monotherapy and Carbidopa-Levodopa) | uiiyzmbhbg(bzzrghzxzk) = obonpseyki iaoektcfoa (dfmsvbujxo, 0.14) View more | - | 17 Jun 2025 | ||
Placebo 1 (Placebo) | uiiyzmbhbg(bzzrghzxzk) = swdatixqsu iaoektcfoa (dfmsvbujxo, 0.18) View more | ||||||
Phase 3 | - | 495 | ujzzkiibrk(vwxfvfdmhm) = yzpidwthax znptffrdnr (bbirbdufvw ) | Positive | 07 Apr 2025 | ||
Immediate-Release Carbidopa-Levodopa (IR CD-LD) | ujzzkiibrk(vwxfvfdmhm) = fyhspmjykj znptffrdnr (bbirbdufvw ) | ||||||
Phase 3 | Parkinson Disease levodopa-equivalent-daily-dose (LEDD) of DA | - | cnxmkjgliz(lrubbppfzp) = thgiccxipi ahifddiule (pvnnsyrwzq ) | Positive | 07 Apr 2025 | ||
Dopamine agonist LEDD ≤200mg | cnxmkjgliz(lrubbppfzp) = vqdjjxbddo ahifddiule (pvnnsyrwzq ) | ||||||
Phase 3 | 232 | qixrjcasaq(rfwaqazjvi) = ykfxewwhos quccavapfg (zxcnbhzmkf ) | Positive | 07 Apr 2025 | |||
Immediate-Release Levodopa/Carbidopa (IR-LD/CD) | qixrjcasaq(rfwaqazjvi) = jvmqhvwxag quccavapfg (zxcnbhzmkf ) | ||||||
Phase 3 | - | eeemzodhcc(acomdfwhfj) = wovgaawhlf btqrumulkk (iamxsmmhks ) View more | Positive | 30 Sep 2024 | |||
NCT03670953 (FDA_CDER) Manual | Phase 3 | 630 | rerxojnipq(tjupaywvyp) = ndfkyygbpy muknchbyyn (oxexoaslwn ) View more | Positive | 07 Aug 2024 | ||
rerxojnipq(tjupaywvyp) = ikianmhfgi muknchbyyn (oxexoaslwn ) View more | |||||||
Phase 2 | 19 | 24h ND0612 infusion | ughmvedglk(behholuyqz) = 73.7% of patients self-reported an improvement (including 36.8% very much/much improved) in their global impression of health on Day 3 baixobjfiz (rgxsowuogr ) | Positive | 28 Jun 2024 | ||
Phase 3 | - | Levodopa/carbidopa infusion (ND0612) | uwwlafjdli(foplxnlnxw) = Occurrence of adverse events (AEs) and serious AEs were generally consistent across subgroups (age, gender, region, and BMI). Consistent with the data for the full safety population, the most common AEs with ND0612 treatment across all subgroups were infusion site reactions. Overall, no relevant differences between subgroups were observed for AEs of particular interest, including dyskinesia, hallucinations, or falls. guvuyititj (ahjjqqjzie ) | Positive | 28 Jun 2024 |