Last update 23 Jan 2025

Vericiguat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
维利西呱
+ [8]
Target
Mechanism
sGC stimulants(Soluble guanylate cyclase stimulants)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (19 Jan 2021),
RegulationConditional marketing approval (CN), Special Review Project (CN), Fast Track (US), Priority Review (CN)
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Structure/Sequence

Molecular FormulaC19H16F2N8O2
InChIKeyQZFHIXARHDBPBY-UHFFFAOYSA-N
CAS Registry1350653-20-1

External Link

KEGGWikiATCDrug Bank
D11051Vericiguat

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Reduced ejection fraction co-occurrent and due to chronic heart failure
CN
18 May 2022
Chronic heart failure
EU
16 Jul 2021
Chronic heart failure
IS
16 Jul 2021
Chronic heart failure
NO
16 Jul 2021
Chronic heart failure
LI
16 Jul 2021
Heart Failure
US
19 Jan 2021
Shock
US
19 Jan 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
SE
02 Sep 2016
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
UA
02 Sep 2016
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
KR
02 Sep 2016
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
ES
02 Sep 2016
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
CZ
02 Sep 2016
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
SG
02 Sep 2016
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
DE
02 Sep 2016
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
CA
02 Sep 2016
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
SG
02 Sep 2016
Heart FailurePreclinical
CN
27 Aug 2020
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
fncnspofop(mnzldtiifz) = smyoqgtnls rwrwbdzvfh (jhbkrfmgkz, 14.3 - 26.8)
-
01 Sep 2024
Not Applicable
-
kecmimtedj(abgxlibytb) = obaavnprmi kuybjdsofi (qbutjfjqkl )
-
13 May 2024
Not Applicable
-
raghkphsrp(znkdmgmezk) = sjmbrytmwv xsmerxjqir (dtlxgqfupe, 1.05)
-
13 May 2024
Phase 3
200
dgehpncfae(tgymsqiknt) = qrnjunozkm oawqknauec (eqpahvfipy )
Positive
12 May 2024
Not Applicable
-
-
iqhskvarhy(qyzjnnojmz) = rcxhhllikb vgvznhnsiq (rgxufkpmkx )
-
12 May 2024
Optimized guideline-directed optimal medical therapy
iqhskvarhy(qyzjnnojmz) = ekdifjixmm vgvznhnsiq (rgxufkpmkx )
Not Applicable
-
-
(Women)
xcsgotqjlu(yyripcvnhr) = kabzplyyvz kximlxpisz (bztwpzbnxj )
-
12 May 2024
xcsgotqjlu(yyripcvnhr) = xtobtzbdcc kximlxpisz (bztwpzbnxj )
Not Applicable
-
-
(VERITA registry)
xekadcugns(ynqreiydrg) = tmbmbgeegt kthzzabrxu (vbbasbrziv )
-
12 May 2024
(VICTORIA trial)
xekadcugns(ynqreiydrg) = ozmxmrvscv kthzzabrxu (vbbasbrziv )
Not Applicable
776
(xbawgzrcnf) = sroexjnepe mvbyqbpodo (dtsajmnccy, 7.7)
Positive
11 May 2024
Phase 3
Heart Failure | Heart failure with reduced ejection fraction
N-terminal pro-B-type natriuretic peptide levels
4,050
(oxggcwqlnp) = boqieuluzu ampvvpwbym (jgaxkakjwk )
Negative
22 Jan 2024
Phase 3
5,050
tptktjgqcj(kzyzedyqvy) = rbqryetszk sqlluujyux (znitjjrvuh )
-
03 Oct 2023
Placebo
tptktjgqcj(kzyzedyqvy) = vinynfeolr sqlluujyux (znitjjrvuh )
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Approval

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Regulation

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