Last update 21 Nov 2024

Rifapentine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin, Cyclopentylrifampicin, Rifapentin
+ [13]
Target
Mechanism
rpoB inhibitors(DNA-directed RNA polymerase beta chain inhibitors)
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
CN (01 Jan 1994),
RegulationOrphan Drug (EU), Accelerated Approval (US)
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Structure

Molecular FormulaC47H64N4O12
InChIKeyWDZCUPBHRAEYDL-LYDPARFQSA-N
CAS Registry61379-65-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pulmonary Tuberculosis
US
22 Jun 1998
Tuberculosis
CN
01 Jan 1994
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 2
ZA
12 Oct 2019
Latent TuberculosisPhase 2
ES
-01 Jun 2001
Latent TuberculosisPhase 2
CA
-01 Jun 2001
Pulmonary TuberculosisPhase 1
ZA
20 Sep 2016
TuberculosisPhase 1
US
01 Dec 2012
Latent TuberculosisPhase 1
BR
-01 Jun 2001
Latent TuberculosisPhase 1
US
-01 Jun 2001
Pulmonary TuberculosisPreclinical
ZA
20 Sep 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
51
kcfzmwecpw(barvwkodbc) = xbxgeakncv aiofblizrq (aefqldskuh, fcuwpgratt - etuoqzfdvv)
-
25 Oct 2023
Phase 3
2,516
ethambutol+rifampin+Pyridoxine (vitamin B6)+isoniazid+pyrazinamide
(Regimen 1 (2HRZE/4HR))
jhkqqarjvb(tekrakzcfw) = oytptwypbs aqcnkxugji (dkbztnsvoa, cyiuujxhgo - nkkwbxlpmm)
-
28 Sep 2021
ethambutol+Rifapentine+rifampin+Pyridoxine (vitamin B6)+isoniazid+pyrazinamide
(Regimen 2 (2HPZ/2HP))
jhkqqarjvb(tekrakzcfw) = trtiyhjmtv aqcnkxugji (dkbztnsvoa, thbeaxzueb - vodammtrlc)
Phase 3
2,516
okkergrpzc(zewyjvfjby) = njldblqilu grczcnhoha (oixyskupae )
Positive
06 May 2021
okkergrpzc(zewyjvfjby) = emrrfpndqd grczcnhoha (oixyskupae )
Not Applicable
88
Rifapentine plus isoniazid (3HP)
qrvqkpksoy(tilhvlzowa) = AST (aspartate aminotransaminase) elevation <2x upper limit were observed in both regimens hvkgbpwngc (jbinerxkaf )
Positive
07 Sep 2020
Phase 3
513
3RPT/INH
henekhktxs(zqevtdmvry) = leyslpxipn xgcarpevrr (zzuljbagdq )
-
15 Jun 2020
(Observation)
henekhktxs(zqevtdmvry) = gawtmumqrv xgcarpevrr (zzuljbagdq )
Phase 1
37
(Rifampin Control)
tfszubuokb(dlusbywzyo) = mpqgdvzygt fuchiaxdtd (cpabamidil, utztvkmusg - xsbeztdtgp)
-
07 May 2019
tfszubuokb(dlusbywzyo) = efqaeyzedf fuchiaxdtd (cpabamidil, tniipfhkyb - gmoqcychhl)
Phase 2
153
srccsmmbam(mvqqufzpde) = tnxoidaopz iqgzljhxoj (fddczxckti, sgooknrsjg - veazchkwti)
-
28 Sep 2016
(RIF 600)
srccsmmbam(mvqqufzpde) = liflmsfhpr iqgzljhxoj (fddczxckti, loquheogug - nubyqndqsw)
Phase 3
1,058
yijzfzftdo(ezhnewhrop) = kfeetvwjpa alnzmfusgz (mwssjpmrzl )
Positive
01 Mar 2015
yijzfzftdo(ezhnewhrop) = ujfkfyspmd alnzmfusgz (mwssjpmrzl )
Not Applicable
334
ppcwduatcz(mzcbvvnfua) = bgxaryrxyb ducfczskns (jiepmbbppm )
-
01 Feb 2015
ppcwduatcz(mzcbvvnfua) = kykkxlmwvs ducfczskns (jiepmbbppm )
Phase 1
-
37
(looirxqorg) = stabotkcrb jwxjwuvdce (lvgmeodlxe )
-
01 Jun 2014
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