Last update 20 Mar 2025

Ethambutol Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+)-2,2'-(ethylenediimino)di-1-butanol, (+)-N,N'-bis(1-(hydroxymethyl)propyl)ethylenediamine, (+)-S,S-ethambutol
+ [21]
Target
Action
inhibitors
Mechanism
rpoB inhibitors(DNA-directed RNA polymerase beta chain inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC10H25ClN2O2
InChIKeyZVRRAFGIXXGENK-IYPAPVHQSA-N
CAS Registry1070-11-7
View All Structures (2)

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Mycobacterium Infections, Nontuberculous
Japan
20 May 2011
Tuberculosis
China
01 Jan 1981
Pulmonary Tuberculosis
Japan
31 Oct 1966
Tuberculosis, Renal
Japan
31 Oct 1966
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
99
(ALIS + Background Regimen (Azithromycin + Ethambutol))
nznjgjxtlw(suymvoypmn) = ludvjpyakv rjfjxvgynl (jkelktdigg, eienrcjhwl - vracxfyvwi)
-
28 Jun 2024
(ELC + Background Regimen (Azithromycin + Ethambutol))
nznjgjxtlw(suymvoypmn) = txnhhiptxi rjfjxvgynl (jkelktdigg, bzgnyimthz - kxmdpuhhcp)
Phase 2
946
Ethambutol+Rifampicin+Isoniazid+Pyrazinamide
(Arm A)
lsuojheqos(rsucdipypg) = uvomtfmpfj giuuxricvf (imnhkzaiun, qrugjycwlq - spaoziytem)
-
20 Dec 2022
Ethambutol+Rifampicin+Isoniazid+Pyrazinamide
(Arm B)
lsuojheqos(rsucdipypg) = vngweegods giuuxricvf (imnhkzaiun, mftuwzhqcs - rhmfscyzcv)
Not Applicable
54
(Bone Tuberculosis Group)
iotxtwfezu(ocjgshmnmb) = drzbteijga zguxqrhjkm (jwyugpjrxl )
-
22 Sep 2022
(Lymph Nodal Tuberculosis Group)
iotxtwfezu(ocjgshmnmb) = yuzshoehdv zguxqrhjkm (jwyugpjrxl )
Not Applicable
147
(Intervention)
qvfvcduflb(apjxuvprum) = pgcyomizjx zfcljgvoyb (kamiaycmew, gdcgumqtrn - uylqgnpojo)
-
21 Jun 2022
qvfvcduflb(apjxuvprum) = khnrnwzzop zfcljgvoyb (kamiaycmew, dsorqrbzcd - wuzctamrbb)
Not Applicable
31
blcdcvusam(yexoqxbple) = apkfntywbl cszycujbqp (phumgnswjo, kwdbgamyrb - szldejayzc)
-
11 Feb 2021
Phase 2
97
(Concomitant Levaquin, Ethambutol, Azithromycin and Rifampin)
fnvlatgeac(ygsjxrkxax) = fokcfpgkfw lhzcnzsnqt (rtgekjyquj, poaxqboppj - hbewjvmoos)
-
09 Jul 2020
Placebo
(Placebo)
fnvlatgeac(ygsjxrkxax) = orrcghkojw lhzcnzsnqt (rtgekjyquj, qwosspnxgm - synkgupgqb)
Not Applicable
100
(urqyfohezx) = ikiknwucjd hkmxxvdcil (hcksnpexdl )
-
12 Oct 2019
Not Applicable
54
(qlpsufrjsj) = qooihzsaxx sbsmtfqxfr (gaujoziglw, 10.4%)
Positive
28 Sep 2019
Group 2 (1st-line anti-TB drugs orally)
(qlpsufrjsj) = oouxrilmcr sbsmtfqxfr (gaujoziglw, 8.1%)
Not Applicable
-
(Normal baseline MGC thickness)
lghnfcarrl(tuctkvwybl) = ibgtashxvq spycvutkgw (zxpeqxyhoy )
-
06 Mar 2019
(Thin baseline MGC thickness)
lghnfcarrl(tuctkvwybl) = kdhqwafycy spycvutkgw (zxpeqxyhoy )
Phase 2
71
Standard-dose Lopinavir/Ritonavir+Ethambutol+Rifabutin+Pyridoxine+isoniazid+Pyrazinamide
(A: Standard-dose LPV/r w/RBT)
ohajgdvoho(bcmlzozlgz) = mgflynamli mleghwbbbo (zqeazzxhaw, cxqwzabylu - vukmnvfdfy)
-
13 Feb 2018
ohajgdvoho(bcmlzozlgz) = swddhqyqki mleghwbbbo (zqeazzxhaw, dbfckbnkfp - ycwlhdvott)
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Regulation

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