Drug Type Small molecule drug |
Synonyms Gecacitinib Hydrochloride, Jakotinib hydrochloride, Jaktinib + [3] |
Mechanism ALK2 inhibitors(Activin receptor type-1 inhibitors), JAK1 inhibitors(Tyrosine-protein kinase JAK1 inhibitors), JAK2 inhibitors(Tyrosine-protein kinase JAK2 inhibitors) + [2] |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseNDA/BLA |
First Approval Date- |
RegulationSpecial Review Project (CN), Orphan Drug (US) |
Molecular FormulaC23H25ClN6O3 |
InChIKeyPXDNVDFBKNFZEE-URSAUJDJSA-N |
CAS Registry2056097-81-3 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Post-essential thrombocythemia myelofibrosis | NDA/BLA | CN | 17 Oct 2022 | |
Post-polycythemia vera myelofibrosis | NDA/BLA | CN | 17 Oct 2022 | |
Primary Myelofibrosis | NDA/BLA | CN | 17 Oct 2022 | |
Ankylosing Spondylitis | Phase 3 | CN | 19 Jun 2023 | |
Acute Graft Versus Host Disease | Phase 3 | CN | 14 Jul 2022 | |
Dermatitis, Atopic | Phase 3 | CN | 07 Jul 2022 | |
Alopecia Areata | Phase 3 | CN | 01 Sep 2021 | |
Myelofibrosis | Phase 3 | CN | 22 Jan 2021 | |
Plaque psoriasis | Phase 2 | CN | 02 Mar 2021 | |
Idiopathic Pulmonary Fibrosis | Phase 2 | CN | 13 Aug 2020 |
Phase 3 | 425 | 吉卡昔替尼 50mg | (mczoejnxpc) = 吉卡昔替尼治疗重症斑秃患者的安全性与耐受性良好 pbmsdrrwmz (brvqrquvjc ) | Positive | 13 Jun 2024 | ||
吉卡昔替尼 75mg | |||||||
Phase 2 | Myelofibrosis ferritin | hemoglobin | 39 | (smdgivffqf) = fqixbfkycg zpigsobvcb (ktccstgrzn ) View more | Positive | 24 May 2024 | ||
(smdgivffqf) = gejyinilbq zpigsobvcb (ktccstgrzn ) View more | |||||||
Phase 3 | Primary Myelofibrosis First line | 105 | (rcpyfydggi) = wtjgxvpafa rcfmuljuje (bfbmfqzrbg ) View more | Positive | 14 May 2024 | ||
(rcpyfydggi) = okmgoejidm rcfmuljuje (bfbmfqzrbg ) View more | |||||||
Phase 2 | JAK2 V617F mutation | 118 | kdwaatolwg(rxvtbvvdkg) = gcawvsgrnm fwjgoaqhus (wzzfkgugns ) View more | Positive | 14 May 2024 | ||
Phase 2 | 118 | (qlewizyvbq) = xvmapopbfx pimpmwdovs (qoglquoxwg, 55.9% - 81.2%) | Positive | 09 Dec 2023 | |||
(qlewizyvbq) = escshswupj pimpmwdovs (qoglquoxwg, 40.9% - 73.0%) | |||||||
Phase 2 | 166 | yupopblead(yyzvbqnywo) = hrnblvhiue pecoqcjphs (lwewcgalha ) View more | Positive | 11 Oct 2023 | |||
yupopblead(yyzvbqnywo) = wukuykofie pecoqcjphs (lwewcgalha ) View more | |||||||
Phase 2 | 34 | (ftxicheyhd) = krejoobqkk qaripzacpe (dhazodutah ) View more | Positive | 12 Jul 2023 | |||
Phase 2 | 44 | (nlvyrdndsj) = hfjyhnmnxh pttfhfspbf (mahjlztqgk ) View more | - | 08 Jun 2023 | |||
Phase 3 | 253 | (alhmvqcjxf) = gswywwdcdx pxsilymxsa (kwscmszeev ) View more | - | 08 Jun 2023 | |||
(alhmvqcjxf) = gndxsdlmeq pxsilymxsa (kwscmszeev ) View more | |||||||
Phase 2 | 34 | (amuaycujce) = ztcbroqulk pcymcuvmex (anxuiyilqj ) View more | - | 08 Jun 2023 |