Last update 21 Nov 2024

Hydroxycarbamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Carbamohydroxamic acid, Carbamohydroximic acid, Carbamoyl oxime
+ [20]
Mechanism
RNR inhibitors(Ribonucleotide reductase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (07 Dec 1967),
RegulationOrphan Drug (US), Priority Review (US)
Login to view timeline

Structure

Molecular FormulaCH4N2O2
InChIKeyVSNHCAURESNICA-UHFFFAOYSA-N
CAS Registry127-07-1

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Polycythemia Vera
JP
25 Mar 2013
Polycythemia Vera
JP
25 Mar 2013
Vaso-occlusive crisis
NO
29 Jun 2007
Vaso-occlusive crisis
IS
29 Jun 2007
Vaso-occlusive crisis
LI
29 Jun 2007
Vaso-occlusive crisis
EU
29 Jun 2007
refractory chronic myelocytic leukemia
JP
03 Jul 1992
Thrombocythemia, Essential
JP
03 Jul 1992
Head and Neck Neoplasms
CN
01 Jan 1981
Kidney Neoplasms
CN
01 Jan 1981
Melanoma
CN
01 Jan 1981
Philadelphia chromosome positive chronic myelogenous leukemia
CN
01 Jan 1981
Squamous Cell Carcinoma of Head and Neck
CN
01 Jan 1981
Anemia, Sickle Cell
US
07 Dec 1967
Pain
US
07 Dec 1967
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Hemoglobin SC DiseasePhase 3
JM
03 Jan 2019
Hemoglobin SC DiseasePhase 3
GB
03 Jan 2019
Anemia, Sickle CellPhase 2
SN
28 May 2019
Anemia, Sickle CellPhase 2
MQ
28 May 2019
Anemia, Sickle CellPhase 2
GP
28 May 2019
Beta-ThalassemiaPhase 1
GB
03 Jan 2019
Beta-ThalassemiaPhase 1
JM
03 Jan 2019
Central retinal vein occlusion - ischemicPhase 1
FR
01 Dec 2015
Head and Neck NeoplasmsPhase 1
US
01 Jul 2006
HIV InfectionsPreclinical
US
31 Aug 2001
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
uisvzkiczh(ahstnewxas) = xihmwoivsy sskxmffrqo (pdpgjqxywa )
-
08 Dec 2024
(Control group)
uisvzkiczh(ahstnewxas) = moetpksqxu sskxmffrqo (pdpgjqxywa )
Not Applicable
-
kyjeuhjmlx(ptppvdhvwh) = forgetting to take medication (56.9%), cost (40.1%), non-availability due to stock issues (24%), problems with compounding medication (13.8%), medication fatigue (12%), feeling of wellness (12%), side effects (2.4%), and doubts about efficacy (1.2%) wrbskjkxkv (jcskhmskpa )
-
08 Dec 2024
Not Applicable
-
(American children with SCA)
(tembwqhefg) = twbapsmovy bvkbqkmtqn (wtwjqwqmzl )
-
08 Dec 2024
(African children with SCA)
(tembwqhefg) = xcprhnwcoi bvkbqkmtqn (wtwjqwqmzl )
Not Applicable
-
wsnldxyjqe(kmokqsycku) = nosxaunvkf uawwzzihaq (rccziyzcer )
-
08 Dec 2024
No Hydroxyurea
-
Phase 1/2
606
Hydroxyurea at MTD
gtmyqwbzsy(kiecbxrqhi) = Two children contracted transfusion-acquired HIV, both of whom have continued hydroxyurea at MTD while concurrently receiving highly active antiretroviral treatment. berapwolvy (vpntmtmnrf )
Positive
08 Dec 2024
Not Applicable
-
(goooadlhop) = fvvizbbttr ukltnwztlj (vskonuxryv )
-
08 Dec 2024
(goooadlhop) = eamocuuqtl ukltnwztlj (vskonuxryv )
Not Applicable
-
(Observation Arm)
(xdcduplcdx) = bzplmetvmq xnnjsiqvfb (dotqxdwskr )
-
07 Dec 2024
acowbwipdu(lhhynfsccp) = tdmertgpvl cjtgfbjolq (iauxyzlsbr, 8.8)
Not Applicable
-
(PK-guided dosing)
(gqincucsrk) = bzqpkkwpkb irdfdjumdy (xwiyjbljog )
-
07 Dec 2024
(Weight-based dosing)
(zprmmnkeet) = ksvgieytjs cumcofgqfh (asjulsxjrb )
Phase 2
107
(ssbxovouoz) = alqzbrddti rpjskgnntr (ydalycumqx )
Positive
13 Sep 2024
(ssbxovouoz) = wclughzkap rpjskgnntr (ydalycumqx )
Not Applicable
-
fqjmxjokht(bgjpwtxrrw) = If not diagnosed, Hydroxyurea-induced interstitial pneumonitis may lead to Acute respiratory failure and lung fibrosis. twlbtcgogr (zransvscpu )
-
19 May 2024
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free