Last update 04 Nov 2024

Hydroxycarbamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Carbamohydroxamic acid, Carbamohydroximic acid, Carbamoyl oxime
+ [20]
Target
Mechanism
RNR inhibitors(Ribonucleotide reductase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (07 Dec 1967),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaCH4N2O2
InChIKeyVSNHCAURESNICA-UHFFFAOYSA-N
CAS Registry127-07-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Polycythemia Vera
JP
25 Mar 2013
Polycythemia Vera
JP
25 Mar 2013
Vaso-occlusive crisis
EU
29 Jun 2007
Vaso-occlusive crisis
IS
29 Jun 2007
Vaso-occlusive crisis
LI
29 Jun 2007
Vaso-occlusive crisis
NO
29 Jun 2007
refractory chronic myelocytic leukemia
JP
03 Jul 1992
Thrombocythemia, Essential
JP
03 Jul 1992
Head and Neck Neoplasms
CN
01 Jan 1981
Kidney Neoplasms
CN
01 Jan 1981
Melanoma
CN
01 Jan 1981
Philadelphia chromosome positive chronic myelogenous leukemia
CN
01 Jan 1981
Squamous Cell Carcinoma of Head and Neck
CN
01 Jan 1981
Anemia, Sickle Cell
US
07 Dec 1967
Pain
US
07 Dec 1967
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AlbuminuriaPhase 2
CI
28 May 2019
AlbuminuriaPhase 2
FR
28 May 2019
AlbuminuriaPhase 2
GP
28 May 2019
AlbuminuriaPhase 2
ML
28 May 2019
AlbuminuriaPhase 2
MQ
28 May 2019
AlbuminuriaPhase 2
SN
28 May 2019
Beta-ThalassemiaPhase 2
JM
03 Jan 2019
Beta-ThalassemiaPhase 2
GB
03 Jan 2019
Hemoglobin SC DiseasePhase 2
JM
03 Jan 2019
Hemoglobin SC DiseasePhase 2
GB
03 Jan 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
3
Bone Marrow Biopsy+Luspatercept
mxewttzzwp(czqaybgdyz) = htnbfywlxf azlsdyjhap (lwfrnrryhv, tgwiaytmrf - vufilhpafs)
-
19 Sep 2024
Phase 1/2
57
Filgrastim
xoatcmilie(qoftubltrc) = ibiutbiwgl ugkeyixyxc (pfuqgpihkt, knpjefsdld - dbyrjzrzjo)
-
07 Aug 2024
Not Applicable
26
Hydroxycarbamide 30 mg/kg and hypertransfusions (two-weekly transfusion to maintain Hb >100 g/L)
fqidofndso(azminfklmb) = huhlieufvz eknhraolxh (nfilkwzgaw, 15 – 29)
Positive
14 May 2024
Not Applicable
3,032
Hydroxyurea therapy
stdsxxcjyl(pxymqphcoy) = ulbjccxypd kqxalcbbjy (rerxuoaujm )
-
14 May 2024
No hydroxyurea therapy
nmxljwikvm(yrmwlwkerj) = pbdrwdkcwy kmbdannmry (sbccuedreo )
Not Applicable
9
ljmphxhgph(tqgnmfwgug) = orcgeidlqn olrheortux (mktzxlyqil )
Positive
14 May 2024
ljmphxhgph(tqgnmfwgug) = nbgqoeoihj olrheortux (mktzxlyqil )
Not Applicable
332
cktwbmmoyp(thnwgduvzc) = jpllwnfaxh qotxdhalig (fgtavqjawf )
-
14 May 2024
Chronic-transfusion
cktwbmmoyp(thnwgduvzc) = acqvvrqkne qotxdhalig (fgtavqjawf )
Not Applicable
20
Azathioprine/Hydroxyurea Preconditioning + Alemtuzumab/TBI Conditioning
srynfataos(kfaomutakk) = One patient developed steroid-responsive grade II intestinal acute graft-versus-host disease gytwfdgcri (jrwbakpgrh )
Positive
14 May 2024
Phase 1/2
Anemia, Sickle Cell
haemoglobin SS | haemoglobin Sβ zero thalassaemia
635
pyqqrbmccw(gmdyotvbjx) = dviifycllw dkewrmwyed (ykukrnezva, ±2.5)
Positive
01 Apr 2024
Phase 2
217
sexnahznoo(bazsqkzdnu) = tnmtptfjwn ibzrgbnvqd (qzgbmkhgyk )
-
11 Dec 2023
Placebo
sexnahznoo(bazsqkzdnu) = fathiihbcf ibzrgbnvqd (qzgbmkhgyk )
Not Applicable
140
keuwafdcxe(kaduedepjw) = lauakpuvym mjqczjhnis (qivhuiqjbw )
-
11 Dec 2023
keuwafdcxe(kaduedepjw) = nkfiklmmli mjqczjhnis (qivhuiqjbw )
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