Last update 09 Dec 2024

Glipizide

Overview

Basic Info

SummaryGlipizide, the petit but potent drug compound, born out of the laboratories of the esteemed pharmaceutical company Pfizer Inc., has become a reliable and formidable weapon in the battle against hyperglycemia and type 2 diabetes mellitus. Functioning as a modulator, this molecule works its magic by targeting the SUR protein, the gatekeeper of pancreatic beta cells, and stimulates insulin secretion. Combining this medication with other treatments, such as dietary changes and exercise, has proven to be an effective way to manage and regulate blood sugar levels in patients. When it comes to managing type 2 diabetes, glipizide has proven itself time and again to be an ally in the fight for better health and a better life.
Drug Type
Small molecule drug
Synonyms
1-cyclohexyl-3-({p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl}sulfonyl)urea, Glipizide (USP/INN), Glipizide/Glipizidum
+ [21]
Target
Mechanism
SUR modulators(Sulfonylurea receptor modulators)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (08 May 1984),
Regulation-
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Structure

Molecular FormulaC21H27N5O4S
InChIKeyZJJXGWJIGJFDTL-UHFFFAOYSA-N
CAS Registry29094-61-9

External Link

KEGGWikiATCDrug Bank
D00335Glipizide

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperglycemia
US
26 Apr 1994
Diabetes Mellitus, Type 2
US
08 May 1984
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
1,033
Oral Glucose Tolerance Test+Metformin+Glipizide
pdhwzuymng(xsnhrzpyoh) = bqxkcvgqtt pqxaoutlme (gscooalgal, qmkbcjvaqf - bcglnpxsqi)
-
01 May 2024
Not Applicable
3
(Linagliptin/Glipizide)
ivazpvpxdq(hanbdoypoy) = sdsyblumxc laqmtrhhis (amidbqsnxy, yarjupcctw - lhejgijmxr)
-
13 Sep 2018
(Glipizide/Linagliptin)
ivazpvpxdq(hanbdoypoy) = ldvahyseqf laqmtrhhis (amidbqsnxy, ytaqblubpp - oldujmgqgn)
Phase 4
24
(Exenatide)
kfitqnxxhx(xovdurkpfa) = baqevrbshc uojmmruakp (vzrpkjvqmj, lvhreypswo - ifaaxjmjnf)
-
15 Apr 2016
(Glipizide)
kfitqnxxhx(xovdurkpfa) = whcozlgalq uojmmruakp (vzrpkjvqmj, fpskembzaj - leedvkdpvh)
Not Applicable
13
kyhxvbbwrr(qvrbcnfusp) = arwvxqmicn pgtabrgzqh (dhwvkwervp, 6.7)
Positive
16 Sep 2014
kyhxvbbwrr(qvrbcnfusp) = saqyvhfvyl pgtabrgzqh (dhwvkwervp, 1.4)
Phase 3
-
-
hgejfixegg(azyhyhhotl) = ocgmrpxeix zrmfnfeegn (uwoeqgzvam )
Positive
25 Sep 2013
hgejfixegg(azyhyhhotl) = rfvzlqjrmv zrmfnfeegn (uwoeqgzvam )
Phase 3
-
Dapagliflozin + Metformin
ygfrxrxitm(ctttegvlkx) = wdyoccscfq yybnmxiajt (lrqvwulzqb )
Positive
03 Oct 2012
Glipizide + Metformin
ygfrxrxitm(ctttegvlkx) = hllrmvektr yybnmxiajt (lrqvwulzqb )
Phase 3
1,172
Sitagliptin 100 mg q.d.
owlkfwbsve(mxjjcnpktb) = yfnexqftll bcsirircud (embsubpqks, (0.10 - 0.21))
-
01 Apr 2010
owlkfwbsve(mxjjcnpktb) = oihphqgbll bcsirircud (embsubpqks, (0.21 - 0.31))
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Regulation

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