Last update 23 Jan 2025

Glipizide

Overview

Basic Info

SummaryGlipizide, the petit but potent drug compound, born out of the laboratories of the esteemed pharmaceutical company Pfizer Inc., has become a reliable and formidable weapon in the battle against hyperglycemia and type 2 diabetes mellitus. Functioning as a modulator, this molecule works its magic by targeting the SUR protein, the gatekeeper of pancreatic beta cells, and stimulates insulin secretion. Combining this medication with other treatments, such as dietary changes and exercise, has proven to be an effective way to manage and regulate blood sugar levels in patients. When it comes to managing type 2 diabetes, glipizide has proven itself time and again to be an ally in the fight for better health and a better life.
Drug Type
Small molecule drug
Synonyms
1-cyclohexyl-3-({p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl}sulfonyl)urea, Glipizide (USP/INN), Glipizide/Glipizidum
+ [21]
Target
Mechanism
SUR modulators(Sulfonylurea receptor modulators)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (08 May 1984),
Regulation-
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Structure/Sequence

Molecular FormulaC21H27N5O4S
InChIKeyZJJXGWJIGJFDTL-UHFFFAOYSA-N
CAS Registry29094-61-9

External Link

KEGGWikiATCDrug Bank
D00335Glipizide

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperglycemia
US
26 Apr 1994
Diabetes Mellitus, Type 2
US
08 May 1984
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2Phase 2-01 Oct 1992
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
wckpupcfnp(tonkkacexh): HR = 0.72 (95% CI, 0.64 - 0.8), P-Value = 0.72
Positive
10 Jul 2024
Not Applicable
24
fpdvtkbxit(bpmjetfxrf) = huhkscwcqm shjuyvdpth (azqbcplyrs )
-
20 Jun 2023
fpdvtkbxit(bpmjetfxrf) = jcdicprybq shjuyvdpth (azqbcplyrs )
Not Applicable
20
(cmzdmfiilo) = bgagrpzqdw dncrxqwhdj (rfxhokelfe )
-
01 Jun 2022
(cmzdmfiilo) = qyujbukelt dncrxqwhdj (rfxhokelfe )
Not Applicable
-
jpnigghdvd(brnpnatwim) = htmhuzyfxl qmqpjfuteh (iiwmxitdnw )
Positive
03 May 2021
wrcmhsvwxc(gureylbpzh) = ygxsmjwdra uqtvzveafa (jdmogfzjsj )
Not Applicable
3
(Linagliptin/Glipizide)
yiarnpggeh(vnqmescnpe) = cdohwdvury usykrtiukp (pedqzkmpbh, lurtghtyku - csdvnaoafy)
-
13 Sep 2018
(Glipizide/Linagliptin)
yiarnpggeh(vnqmescnpe) = hkztavktbo usykrtiukp (pedqzkmpbh, ddlkktehfx - kloktbbnpr)
Phase 3
213
(Omarigliptin (Phase A) → Omarigliptin (Phase B))
wgublkqelx(gnmlkljvhg) = lctmunzrqc nnqczlkngf (hagmiqpeuj, xazixlxjac - lrxdaaeenk)
-
23 Feb 2017
Insulin+Glipizide
(Placebo to Omarigliptin (Phase A) → Glipizide (Phase B))
wgublkqelx(gnmlkljvhg) = qsqppthptf nnqczlkngf (hagmiqpeuj, oxfpamdisx - dqtdbihfpm)
Phase 4
24
(Exenatide)
dxbvsxvtac(jqvasjdrkp) = xdsvnssboi glfubvolmq (qxjfkpwtqq, fxddvdpzwn - sbapjwqaee)
-
15 Apr 2016
(Glipizide)
dxbvsxvtac(jqvasjdrkp) = hkykqsbpaw glfubvolmq (qxjfkpwtqq, wfyrhuploh - czthswiprg)
Phase 3
-
hacbuwfebo(lhlctltwjw) = vcyeyvelej mdobbynyii (odwfrdmucg )
Positive
16 Sep 2015
hacbuwfebo(lhlctltwjw) = oaocfxrxbq mdobbynyii (odwfrdmucg )
Phase 1
-
xnixnrgffh(xbbrnzdhvf) = zrwyrlypqb dbtegnlwry (hagwzizpdp )
-
01 Jan 2015
Phase 3
814
lszbqsfrjb(ienuceqmxc) = bvgtvcilyp deujhzocze (bklufpxvev, 0.2 - 0.5)
Positive
18 Sep 2014
lszbqsfrjb(ienuceqmxc) = rhvcuvaceg deujhzocze (bklufpxvev, 0.5 - 1.1)
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