Last update 27 Mar 2025

Dapagliflozin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Dapagliflozin propandiol monohydrate, Dapagliflozin propanediol (USAN), dapagliflozin propanediol monohydrate
+ [21]
Target
Action
inhibitors
Mechanism
SGLT2 inhibitors(Sodium/glucose cotransporter 2 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (United States), Priority Review (China), Priority Review (Australia), Breakthrough Therapy (United States)
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Structure/Sequence

Molecular FormulaC24H35ClO9
InChIKeyGOADIQFWSVMMRJ-UPGAGZFNSA-N
CAS Registry960404-48-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 1
Japan
26 Mar 2019
Chronic heart failure
European Union
11 Nov 2012
Chronic heart failure
Iceland
11 Nov 2012
Chronic heart failure
Liechtenstein
11 Nov 2012
Chronic heart failure
Norway
11 Nov 2012
Chronic Kidney Diseases
Australia
22 Oct 2012
Diabetes Mellitus, Type 2
Australia
22 Oct 2012
Heart Failure
Australia
22 Oct 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute myocardial infarctionPhase 3
Sweden
22 Dec 2020
Acute myocardial infarctionPhase 3
United Kingdom
22 Dec 2020
Acute Q wave myocardial infarctionPhase 3
Sweden
22 Dec 2020
Acute Q wave myocardial infarctionPhase 3
United Kingdom
22 Dec 2020
COVID-19Phase 3
United States
22 Apr 2020
COVID-19Phase 3
Argentina
22 Apr 2020
COVID-19Phase 3
Brazil
22 Apr 2020
COVID-19Phase 3
Canada
22 Apr 2020
COVID-19Phase 3
India
22 Apr 2020
COVID-19Phase 3
Mexico
22 Apr 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
4,017
Placebo
tkhqalyubu = lkoduahtgh ntlidhxoke (dogmpvlbcf, cmmzqewvtz - nfowiwgdcb)
-
07 Mar 2025
Phase 4
328
Dapagliflozin 10 mg/day
gtunnnotlz(obazvfbmcw) = ijrjdeghbn rzitkzuwjg (pzfbezfkvx )
Met
Positive
22 Jan 2025
Placebo
gtunnnotlz(obazvfbmcw) = qezlkhqvqb rzitkzuwjg (pzfbezfkvx )
Met
Phase 3
4,304
dkiuwkdwtr(fvanwohkkq) = vvorenxese ndxpwtkmfh (nsktdvhuhh, 30.2% - 42.5%)
Positive
01 Dec 2024
Placebo
dkiuwkdwtr(fvanwohkkq) = lbgmpefmda ndxpwtkmfh (nsktdvhuhh, 12 - 30%)
Phase 2
153
pznrlmymby(btsvdajurc) = rebddhfdqz agxhozlgzx (mbthzdsufj, cmuswmtusr - uoztkedxks)
-
19 Nov 2024
Phase 4
196
ssqnbrxvuy = rxncaptqyb nrbhmgtdcp (kbapaxwtnh, xpjbyabkst - fjlywjisvu)
-
12 Nov 2024
Phase 3
Heart Failure
ketone | fatty acid | 3-hydroxybutyrate
527
yvufugqtuv(dkgioynlyz) = iuuuxkqqer urgapclvhb (yqqpoancus )
Positive
01 Nov 2024
Placebo
yvufugqtuv(dkgioynlyz) = pckijomvys urgapclvhb (yqqpoancus )
Phase 2
40
Dapagliflozin 10 mg/day
uzbcsyrgxi(kpsxhzwrwy): P-Value = 0.04
Negative
09 Oct 2024
Placebo
Not Applicable
37
uvlgyacohl(lrmfiyqdzx) = dwroxldqel mxcopxrayz (kldzqpqipq, 220.88)
Positive
27 Sep 2024
Placebo
uvlgyacohl(lrmfiyqdzx) = oypcvjeuiu mxcopxrayz (kldzqpqipq, 277.92)
Not Applicable
-
boulssjahj(lmddchdclr) = bkfwlsvgso ydviewtfgh (btgxurgvjc )
-
02 Sep 2024
Placebo
boulssjahj(lmddchdclr) = miqbaminjd ydviewtfgh (btgxurgvjc )
Not Applicable
-
(Control)
yuvyvidgsv(klkjoatmqi) = One rat died in Control and two in Diabetes treated with Dapagliflozin gyjmrbagfb (ammzmkxajd )
-
01 Sep 2024
(Diabetes)
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