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Seeking to rebound from a surprise setback for one of its key pipeline assets, AstraZeneca on Monday — alongside reporting second-quarter financial results — reaffirmed confidence in its forecast for the current year, as well as its outlook through 2023. "We are on track to deliver our $80 billion total revenue ambition, which assumes successes and setbacks," said CEO Pascal Soriot, adding "we remain confident in the strength of our pipeline."AstraZeneca and partner Ionis Pharmaceuticals announced earlier this month that the Phase III CARDIO-TTRansform study of eplontersen in patients with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM) failed to meet its primary endpoint, sending the UK drugmaker's shares down as much as 9%. For further analysis, read — Spotlight On: AstraZeneca investors wake up to surprise setback and Spotlight On: Alnylam's whiplash over AstraZeneca's TTRansformative miss.Expectations for CARDIO-TTRansform had been high, both from AstraZeneca and the scientific community. "It should have worked," Soriot said Monday, with the findings, showing that eplontersen — already on the market as Wainua and Wainzua — didn't work in conjunction with a stabiliser therapy, representing a "very important learning for the cardiology community." Separately on Monday, AstraZeneca reported a disappointing outcome for Ultomiris (ravulizumab) in adults and adolescents with thrombotic microangiopathy, as well as a positive Phase III read out for its Claudin 18.2-targeting antibody-drug conjugate sonesitatug vedotin in patients with advanced or metastatic gastric cancer. "Biology is biology, it doesn't always deliver what you expect," Soriot said.Oncology drugs growIn the second quarter, AstraZeneca reported that sales rose 6% to $15.4 billion, boosted by double-digit growth in oncology and rare diseases, which offset headwinds from loss of exclusivity to Farxiga in the US — overall revenue from the product slipped 16% to $1.8 billion.Quarterly sales of oncology drugs jumped 27% to $7.3 billion, with revenue from Imfinzi growing 12% to $1.9 billion and Enhertu surging 33% to $888 million. Net income in the three-month period lifted 2% to $2.5 billion.Commenting on the results, Shore Capital analyst Sean Conroy said "the balance between revenue growth and earnings progression is now less favourable than in prior years, given the increasing levels of R&D investment needed in order for it to grow beyond 2030."AstraZeneca also reiterated its outlook for the current year of a mid-to-high single-digit percentage increase in revenue, with core earnings per share growing by a low-double-digit percentage.

iStock, CreativaImages AstraZeneca remains “very much on track” to hit its 2030 goal of reaching $80 billion in revenue despite the recent late-stage failure of Wainua in ATTR-cardiomyopathy, CEO Pascal Soriot said during the company’s Q2 earnings presentation on Monday. The recent surprise stumble of the antisense therapy Wainua in a late-stage ATTR-cardiomyopathy study doesn’t seem to have shaken AstraZeneca, which sees the failure as part of the drug-making business—and one not big enough to have any appreciable effect on its business development strategy moving forward. “It doesn’t really impact our M&A strategy,” CFO Aradhana Sarin told reporters during a press call early Monday morning to present the company’s second quarter earnings report . “This is one setback amongst a whole slew of several positive studies.” CEO Pascal Soriot agreed, noting that while the failure is unfortunate, “it happens, and it’s included in our risk adjustment.” Pointing to the pharma’s expansive pipeline, Soriot added that AstraZeneca doesn’t “need M&A to deliver.” ezstandalone.cmd.push(function () { ezstandalone.showAds(129); }); Aside from Wainua, AstraZeneca on Monday also disclosed several other clinical disappointments, primarily concerning its cancer portfolio. Developed and commercialized in partnership with Ionis Pharmaceuticals, Wainua is a transthyretin silencer that works by suppressing the overall expression of the protein that is misfolded in ATTR, leading to disease-causing clumps across various organs. The therapy was approved in December 2023 for ATTR-polyneuropathy, and the partners are looking to expand into cardiomyopathy with the Phase 3 CARDIO-TTRansform trial. That study failed earlier this month, however, which cast considerable doubt on AstraZeneca’s ability to meet its goal of $80 billion in revenue by 2030—a target set in 2024 . At the time, the pharma named Wainua as a crucial contributor toward meeting that revenue bar. Cardiovascular disease AstraZeneca, Ionis’ Wainua woes send waves across ATTR-CM space The failure of AstraZeneca and Ionis’ Wainua in a late-stage study of ATTR-CM casts doubt on Alnylam’s next-generation candidate but is good news for others in the space, including BridgeBio and Intellia Therapeutics. July 10, 2026 · 3 min read · Tristan Manalac Read more “Of course, as you would expect, we are disappointed” by this failure, Soriot told the press in his opening remarks on Monday. He asserted, however, that AstraZeneca remains “very much on track” to meet the 2030 goal. “Biology is not mathematics, it’s not as predictable,” Soriot said of the failure. “Biology doesn’t always behave the way you would expect.” On Monday, this unpredictability struck again as AstraZeneca reported another late-stage stumble: In the Phase 3 ALXN1210-TMA-313 trial, the pharma’s rare disease powerhouse Ultomiris failed to significantly improve event-free survival versus placebo in patients 12 years and older with thrombotic microangiopathy who had received hematopoietic stem cell transplant. Ultomiris is approved for four rare conditions: paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, generalized myasthenia gravis and neuromyelitis optica spectrum disorder. The drug made $1.3 billion in the second quarter. AstraZeneca revealed several other study failures on Monday, including the Phase 3 PACIFIC-8 trial, testing the PD-L1 inhibitor Imfinzi plus an anti-TIGIT antibody from Gilead in patients with stage 3 unresectable non-small cell lung cancer. Gilead, which was running the study alongside Arcus Biosciences, decided to discontinue the program after disappointing data in separate studies of their TIGIT asset. Meanwhile, in the Phase 3 CLARITY-Gastric01 trial, AstraZeneca’s antibody-drug conjguate sonesitatug vedotin met just one of its primary efficacy endpoints: Overall survival in patients receiving the therapy after at least two prior lines of treatment. Sonesitatug vedotin did not show significant progression-free survival in the overall study population, according to the company’s H1 results presentation. AstraZeneca posted revenues of nearly $15.4 billion in Q2, a 5% year-on-year increase at constant currencies. Much of this growth was driven by the pharma’s oncology portfolio, which surged 15% to hit $7.3 billion in sales. The company also pointed to its rare disease unit as a key driver, which jumped 8% to bring in $2.4 billion in the quarter. Tagrisso, an oral drug for non-small cell lung cancer, reigned as AstraZeneca’s best-selling product in Q2 with $1.9 billion in revenue, up 6% from the same period last year. Close behind was Imfinzi, approved for various cancers, which surged 27% to make $1.9 billion. Farxiga, an SGLT2 inhibitor indicated for chronic kidney disease, heart failure and type 2 diabetes, remained one of AstraZeneca’s top-performing assets with $1.8 billion in Q2 revenue—even as sales took a 19% dive after losing key patent protections . Patents 5 Pharma Powerhouses Facing Massive Patent Cliffs—And What They’re Doing About It Merck’s Keytruda may be the most talked about drug facing loss of exclusivity but it’s far from the only one, as several of the industry’s top-performers are losing key market protections. Some companies are more prepared than others. February 19, 2025 · 10 min read · Tristan Manalac Read more