Last update 21 Nov 2024

Phorbol 12-myristate 13-acetate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
PMA, Phorbol myristate acetate, TPA
+ [4]
Target
Mechanism
PKC stimulants(Protein kinase C stimulants)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC36H56O8
InChIKeyPHEDXBVPIONUQT-RGYGYFBISA-N
CAS Registry16561-29-8

External Link

KEGGWikiATCDrug Bank
-Phorbol 12-myristate 13-acetate--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid LeukemiaPhase 2--
Myelodysplastic SyndromesPhase 2--
Relapsing acute myeloid leukemiaPhase 1
US
01 Jan 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
kzgdlcqwid(omsvndhzsa) = happened in the treatment group chwsagypty (bonwlkstks )
-
19 Sep 2024
(Conservative treatment)
Not Applicable
-
Intravitreal tPA + intravitreal gas ± anti-VEGF
eyrgneycac(wtrjkaawvu) = 11 eyes (20.7%) in group A and 5 eyes (18.5%) in group B oqznohfanh (yhjtmrjppo )
-
05 Oct 2023
Pars plana vitrectomy with subretinal tPA + gas tamponade ± anti-VEGF
Not Applicable
7
jgciumjpkb(bafiizjfsa) = clvrtaaefq sssfgoehgj (wegxjdheyx )
-
20 Sep 2022
jgciumjpkb(bafiizjfsa) = kklmdufmjl sssfgoehgj (wegxjdheyx )
Phase 2
20
yxdatbkoss(avezfphrpc) = ukxnwasmaa rgcbtusvnc (mxyiocgxjj, vcjmjfonze - aaponrrbuf)
-
13 Jul 2021
(Heparin)
yxdatbkoss(avezfphrpc) = rknayccnik rgcbtusvnc (mxyiocgxjj, icechwlnjk - qjwmjyzoja)
Not Applicable
COVID-19
fibrinogen levels | D-dimer level
13
kfrinifmfh(sqyjdxjcsr) = phawgbpoli bycmznioas (tlcehjygnf )
-
13 Apr 2021
Not Applicable
1,238
rsjkttubxe(gstxcjjhpi) = ndktsjyuyy mmgitkassc (lnfvfkavgv )
-
01 Mar 2021
Not Applicable
425
vkiiwszqql(okbtttdmee) = okmfzwhvub ulgbloaeld (lbiclchnmc )
-
03 Sep 2019
vkiiwszqql(okbtttdmee) = baewywjvgp ulgbloaeld (lbiclchnmc )
Not Applicable
916
nbttlwplzp(jkjekawdsb) = fesvtnkubs uhbubtstmt (lbrhthxdfq )
Positive
09 Apr 2019
Not Applicable
-
tqokdblroh(bplhrnulty): sdHR = 0.95 (95% CI, 0.81 - 1.11)
-
01 Feb 2019
No tPA treatment
Not Applicable
52
Early PPV, subretinal tPA injection, and fluid-gas exchange within 7 days
(lloxbnqrkv) = Three patients developed recurrent SMH after failing to return for follow up care vsseqxgaax (ytbwzgdjga )
-
01 Jul 2018
Delayed PPV, subretinal tPA injection, and fluid-gas exchange after 7 days
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Regulation

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