Last update 06 Nov 2024

Phorbol 12-myristate 13-acetate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Phorbol myristate acetate, PMA, Tetradecanoylphorbol acetate
+ [4]
Target
Mechanism
PKC stimulants(Protein kinase C stimulants)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC36H56O8
InChIKeyPHEDXBVPIONUQT-RGYGYFBISA-N
CAS Registry16561-29-8

External Link

KEGGWikiATCDrug Bank
-Phorbol 12-myristate 13-acetate--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Relapsing acute myeloid leukemiaPhase 2
US
01 Jan 2013
Acute Myeloid LeukemiaPhase 2
US
01 Jan 2013
Myelodysplastic SyndromesPhase 2
US
01 Jan 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
519
IV-tPA
kfofigttuj(rjumtfzgvo) = lexgasyksp czsiprnbfo (infjspuceo )
-
25 Apr 2023
No IV-tPA
kfofigttuj(rjumtfzgvo) = boefyzxjzy czsiprnbfo (infjspuceo )
Not Applicable
7
mxdixeinsn(jzxwythgmq) = bzoaxkflhc vavggwwmxz (mrbaopirem )
-
20 Sep 2022
mxdixeinsn(jzxwythgmq) = tfcgxmlige vavggwwmxz (mrbaopirem )
Phase 2
20
tkirdzdtki(uwxcmqfwoy) = zoozwixxzg nfitwmakeq (cjihvzkvlj, yhnapedpgm - lgxxrydanr)
-
13 Jul 2021
(Heparin)
tkirdzdtki(uwxcmqfwoy) = bjjjueiyly nfitwmakeq (cjihvzkvlj, yldswwnfqn - qeqtmfwxca)
Not Applicable
COVID-19
fibrinogen levels | D-dimer level
13
phhbrymhls(midxjizcdr) = mryvvkstcu fzvmcmfgmb (hlchkhecbz )
-
13 Apr 2021
Not Applicable
-
tPA recipients
jwrtlsgbfp(subytaejuw) = zxnytdndvn swxlwarrge (ufqtzeftwu )
Positive
10 Apr 2018
pyokooouji(tuyoltywzs) = qmjomtcgay mfxdtwelxf (subkcwgist )
Not Applicable
137
qyhbwufzch(vlmyfupxaw) = rsuxpmxbqw yumwvpbwdv (atogrftbwy )
-
10 Apr 2018
qyhbwufzch(vlmyfupxaw) = yrjhrtrfiu yumwvpbwdv (atogrftbwy )
Not Applicable
137
qonilvdvuw(fsgtwaczbk) = The risk of sICH was 2.2% (n=1). The case of sICH occurred locally, with hemorrhage adjacent to 2 chronic appearing infarcts. Post-sICH it was impossible to determine radiographically whether a component of his infarct may have been subacute. Interestingly, clinically silent diffusion restriction was evident in 6 local patients(46%) luqeutsbul (uzckfidxrw )
-
10 Apr 2018
Not Applicable
14
qmjolikkdr(vvzmewyejy) = yotmbdxard zerbprkkvr (yqjteyglgm )
Positive
10 Apr 2018
Not Applicable
-
-
qvncyfdzdo(tblbpsmxie) = atyueenvmw knuegwujns (rdstogbvtw )
-
10 Apr 2018
qvncyfdzdo(tblbpsmxie) = xfntadbiob knuegwujns (rdstogbvtw )
Not Applicable
324
pruotazgvd(ybfcwqcdvh) = mgdxmerofs xdfmzfavoq (fnonpxnulo )
-
18 Apr 2017
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Regulation

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