Delving into the Latest Updates on Fluorothymidine F-18 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug, Diagnostic radiopharmaceuticals

Synonyms

+ [1]

Target-

Action

enhancers

Mechanism

PET imaging(Positron-emission tomography enhancers)

Therapeutic Areas

NeoplasmsImmune System DiseasesNervous System Diseases+ [1]

Active Indication

Acute Lymphoblastic LeukemiaBrain Cancer

Inactive Indication

Acute Myeloid LeukemiaAdvanced cancerAdvanced Head and Neck Carcinoma+ [27]

Originator Organization

National Cancer Institute

Active Organization

The Children's Hospital Corp.

Advanced Innovative Partners IncStartup

Inactive Organization

National Cancer Institute

National Institutes of Health

The University of Texas Southwestern Medical Center

+ [3]

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC10H13FN2O4

InChIKeyUXCAQJAQSWSNPQ-ZIVQXEJRSA-N

CAS Registry287114-80-1

This is a prospective pilot study, the primary aim of which is to determine whether the presence of 18F FLT imaging signal uptake abnormalities correlate with clinically validated evidence of hematopoietic malignant disease (e.g. MRD, molecular, flow or histology) after immunotherapy and other treatments.

Start Date19 Jan 2023

Sponsor / Collaborator

University of Oklahoma

[+1]

NCT04309552

/ Active, not recruitingPhase 1IIT

A Phase-I Trial for Simultaneous Imaging of Tumor Hypoxia and Proliferation in Patients With Treatment- Naïve High-Grade Glioma

This is a pilot study to assess a new methodology developed for High Grade Glioma (HGG). FMISO PET (Fluoromisonidazole-PET) allows researchers to study whether tumor cells lack oxygen (hypoxia). FLT PET (Fluorodeoxythymidine-PET) allows researchers to study the increase in the number of cells as a result of cell growth and cell division (proliferation). Tumors that have low oxygen levels and/or are dividing fast shall resist to standard cancer treatment. The study will compare FMISO PET and FLT PET imaging techniques with molecular biomarkers of hypoxia, angiogenesis, and cellular proliferation in tissue. proliferation).This information could help researchers develop new treatment techniques to better treat cancer.

Start Date01 Feb 2021

Sponsor / Collaborator

Weill Medical College of Cornell University

NCT04067115

/ Active, not recruitingPhase 1/2IIT

SARC037: a Phase I/II Study to Evaluate the Safety of Trabectedin Administered As a 1-Hour Infusion in Ewing Sarcoma Patients in Combination with Low Dose Irinotecan and 3'-Deoxy-3'-18F Fluorothymidine (18F-FLT) Imaging

This study evaluates the trabectedin and irinotecan in the treatment of Ewings sarcoma, with a EWS-FLI1 mutation. Patients will also receive an infusion of 18F-FLT in combination with a Positron Emission Tomography (PET) scan to help evaluate the effect of treatment.
Phase I was completed on 11/16/2022. Phase II is actively recruiting.

Start Date05 Jan 2021

Sponsor / Collaborator

Sarcoma Alliance for Research through Collaboration

[+3]

100 Clinical Results associated with Fluorothymidine F-18

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100 Translational Medicine associated with Fluorothymidine F-18

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100 Patents (Medical) associated with Fluorothymidine F-18

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516

Literatures (Medical) associated with Fluorothymidine F-18

15 Apr 2024·Clinical Cancer Research

Noninvasive Stratification of Colon Cancer by Multiplex PET Imaging

Article

Author: Soloviev, Dmitry ; Mackintosh, Agata ; Bielik, Robert ; Campbell, Andrew ; Malviya, Gaurav ; Nixon, Colin ; Lewis, David Y ; Johnson, Emma ; Peters, Adam ; Gilroy, Kathryn ; Lannagan, Tamsin R M ; Brown, Gavin ; Sansom, Owen J ; Jackstadt, Rene

AbstractPurpose:The current approach for molecular subtyping of colon cancer relies on gene expression profiling, which is invasive and has limited ability to reveal dynamics and spatial heterogeneity. Molecular imaging techniques, such as PET, present a noninvasive alternative for visualizing biological information from tumors. However, the factors influencing PET imaging phenotype, the suitable PET radiotracers for differentiating tumor subtypes, and the relationship between PET phenotypes and tumor genotype or gene expression–based subtyping remain unknown.Experimental Design:In this study, we conducted 126 PET scans using four different metabolic PET tracers, [18F]fluorodeoxy-D-glucose ([18F]FDG), O-(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET), 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT), and [11C]acetate ([11C]ACE), using a spectrum of five preclinical colon cancer models with varying genetics (BMT, AKPN, AK, AKPT, KPN), at three sites (subcutaneous, orthograft, autochthonous) and at two tumor stages (primary vs. metastatic).Results:The results demonstrate that imaging signatures are influenced by genotype, tumor environment, and stage. PET imaging signatures exhibited significant heterogeneity, with each cancer model displaying distinct radiotracer profiles. Oncogenic Kras and Apc loss showed the most distinctive imaging features, with [18F]FLT and [18F]FET being particularly effective, respectively. The tissue environment notably impacted [18F]FDG uptake, and in a metastatic model, [18F]FET demonstrated higher uptake.Conclusions:By examining factors contributing to PET-imaging phenotype, this study establishes the feasibility of noninvasive molecular stratification using multiplex radiotracer PET. It lays the foundation for further exploration of PET-based subtyping in human cancer, thereby facilitating noninvasive molecular diagnosis.

01 Jan 2024·European Journal of Nuclear Medicine and Molecular Imaging

Proliferation and apoptosis after whole-body irradiation: longitudinal PET study in a mouse model.

Article

Author: Böning, Guido ; Steiger, Katja ; Ziegler, Sibylle ; von Ungern-Sternberg, Barbara ; Bläske, Alexandra ; Port, Matthias ; Majewski, Matthäus ; Meindl, Maria ; Bartenstein, Peter ; Schüle, Simone ; Palumbo, Giovanna ; Oos, Rosel ; Lauber, Kirsten ; Lindheimer, Felix ; Lindner, Simon ; Brix, Nikko

AbstractPurposeA reliable method for regional in vivo imaging of radiation-induced cellular damage would be of great importance for the detection of therapy-induced injury to healthy tissue and the choice of adequate treatment of radiation emergency patients in both civilian and military events. This study aimed to investigate in a mouse model if positron emission tomography (PET) imaging with proliferation and apoptosis markers is potentially suitable for this purpose.MethodsFour groups, including twenty mice (wild-type C57BL/6) each, were whole-body irradiated with 0 Gy, 0.5 Gy, 1 Gy, and 3 Gy and examined by PET over a six-month period at defined time points. 3'-[18F]fluoro-3'-deoxythymidine ([18F]FLT) and 2-(5-[18F]fluoropentyl)-2-methyl malonic acid ([18F]ML-10) were used to visualise proliferation and apoptosis. Regional standard uptake values were compared with respect to irradiation dose over time. Histologic data and peripheral blood cell values were correlated with the PET results.ResultsThe hematopoietic bone marrow showed a significantly increased [18F]FLT signal at early time points after radiation exposure (day 3 and day 7). This correlated with blood parameters, especially leukocytes, and histological data. A significantly increased [18F]FLT signal also occurred in the gastrointestinal tract and thymus at early time points. An increased [18F]ML-10 signal related to irradiation doses was observed in the bone marrow on day 8, but there was a high variability of standard uptake values and no correlation with histological data.Conclusion[18F]FLT showed potential to visualise the extent, regional distribution and recovery from radiation-induced cellular damage in the bone marrow, gastrointestinal tract and thymus. The potential of [18F]FLT imaging to assess the extent of bone marrow affected by irradiation might be especially useful to predict the subsequent severity of hematopoietic impairment and to adapt the therapy of the bone marrow reserve. [18F]ML-10 PET proved to be not sensitive enough for the reliable detection of radiation induced apoptosis.

01 Nov 2023·International journal of hematology

Hematopoiesis in the spleen after engraftment in unrelated cord blood transplantation evaluated by ¹⁸F-FLT PET imaging.

Article

Author: Hosono, Naoko ; Kiyono, Yasushi ; Yamauchi, Takahiro ; Tsujikawa, Tetsuya ; Okazawa, Hidehiko ; Araie, Hiroaki

Cord blood is an important donor source for allogeneic hematopoietic stem cell transplantation (allo-HSCT), with its unique composition and quality of hematopoietic cells. The proliferation site and potency of infused hematopoietic stem cells in humans may vary between stem cell sources. We investigated this possibility in a prospective, exploratory study to assess hematopoietic dynamics using the radiopharmaceutical 3'-deoxy-3'-¹⁸F-fluorothymidine (¹⁸F-FLT), a thymidine analog used in positron emission tomography imaging, before allo-HSCT and on days 50 and 180 after allo-HSCT. We evaluated 11 patients with hematological malignancies who underwent allo-HSCT [five with peripheral blood stem cell transplantation (PBSCT) and six with unrelated cord blood transplantation (UCBT)]. Before allo-HSCT, ¹⁸F-FLT uptake did not differ between the two groups. At day 50, ¹⁸F-FLT uptake in the spleen was significantly greater in the UCBT group than in the PBSCT group (p = 0.0043), with no difference in whole-body bone marrow. At day 180, the differences in spleen uptake had diminished, and there were no differences between groups in whole-body bone marrow or the spleen, except for the sternum. The persistence of splenic hematopoiesis after engraftment in the UCBT group may reflect the complex systemic homing and proliferation mechanisms of cord blood hematopoietic cells.

100 Deals associated with Fluorothymidine F-18

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External Link

KEGG	Wiki	ATC	Drug Bank
-	Fluorothymidine F-18	-	DB14930

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Lymphoma	Phase 3	United States	National Cancer Institute	29 Sep 2008
Brain Cancer	Phase 2	United States	The Children's Hospital Corp.	01 Oct 2010
Breast Cancer	Phase 2	-	Merck Sharp & Dohme Corp.	08 Apr 2010
Breast Cancer 3	Phase 2	United States	National Cancer Institute	01 Dec 2008
Invasive Mammary Carcinoma	Phase 2	United States	National Cancer Institute	01 Dec 2008
Locally advanced breast cancer	Phase 2	United States	National Cancer Institute	01 Dec 2008
Laryngeal Neoplasms	Phase 2	United States	National Institutes of Health	01 Mar 2008
Mouth Neoplasms	Phase 2	United States	National Institutes of Health	01 Mar 2008
Oropharyngeal Neoplasms	Phase 2	United States	National Institutes of Health	01 Mar 2008
Squamous Cell Carcinoma of Head and Neck	Phase 2	United States	National Institutes of Health	01 Mar 2008

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03276676 (CTgov)	Phase 1/2	Brain Cancer	10	[18F]Fluciclovine+[18F]FLT (Group A)	ntcrxvznsi(qhjdqkonqq) = sjvnhfitrt haisrpdizn (rddshhxbhd, flampcyvcv - mdofjsulqh) View more	-	27 Dec 2024
NCT03276676 (CTgov)	Phase 1/2	Brain Cancer	10	[18F]Fluciclovine+[18F]FLT (Group B)	ntcrxvznsi(qhjdqkonqq) = uykamszguo haisrpdizn (rddshhxbhd, bvdzthrgvj - ryogfdnqbk) View more	-	27 Dec 2024
NCT01244737 (CTgov)	Phase 2	Brain Cancer	50	[18F] FLT (New Diagnosis of Brain Tumor)	syukksopux(bigkuavapx) = cskhyxsepn loyltgeras (sentopgksd, yplhtjtlwf - xeghkmqazu) View more	-	11 Jul 2024
NCT01244737 (CTgov)	Phase 2	Brain Cancer	50	[18F] FLT (Possible Recurrent Brain Tumor)	syukksopux(bigkuavapx) = mzphlwqywj loyltgeras (sentopgksd, vnzulxxoat - lcdhzpmjxl) View more	-	11 Jul 2024
NCT03318497 (CTgov)	Phase 2	Pancreatic adenocarcinoma	6	Computed Tomography+3'-deoxy-3'-[F-18] fluorothymidine: [F-18]FLT	(cqmxkyvljc) = qsbvrhdtbm fsqtwcqoxb (azyepvsafj, ysdtpdxjyd - bqyzqhhlmb) View more	-	08 Nov 2022
NCT01399658 (AMIGO, CTgov)	Phase 2	Vagina Carcinoma \| Uterine Cervical Cancer \| Vulvar Neoplasms	93	Image-guided brachytherapy+3'-Deoxy-3'-18f-Fluorothymidine	zydxfhldwz(erunegqzlw) = izzkilobgk ppsotjgimt (emplgiiinq, avhkeblmuy - ipevceolay) View more	-	02 Mar 2022
EANM2021	Not Applicable	Ki-67	-	18 F-fluorothymidine (Non-irradiation group)	ijmnkoxgzo(mtpxptjjkx) = aqsodvimvr tdhvixhoxg (grqqnjwrhg ) View more	-	24 Sep 2021
EANM2021	Not Applicable	Ki-67	-	18 F-fluorothymidine (Irradiation group)	ijmnkoxgzo(mtpxptjjkx) = eqlnzmqnnc tdhvixhoxg (grqqnjwrhg ) View more	-	24 Sep 2021
NCT00979810 (CTgov)	Not Applicable	High grade glioma	11	18F-FLT PET Scan	zcqghubvya(aqfhtbnuib) = wylmdjvqwr wgwyrfkxbg (anmbdhhmia, areoyidszn - enkkwvdehj) View more	-	17 Dec 2020
EANM2019	Not Applicable	-	-	18 F-FLT	wypcopmfbz(dcibrmayhw) = few dzcpqckpki (nihgvdgeqd ) View more	-	18 Sep 2019
EANM2019	Not Applicable	-	-	18 F-FLT (N-BOC-FLT)		-	18 Sep 2019
ISC2019	Not Applicable	Ischemic stroke Ki67	-	F-18-fluorothymidine (Rats subjected to transient middle cerebral artery occlusion (MCAO))	yumisopwbh(jtkiurmxtb) = cerebral FLT binding activity gradually declined from post MCAO day 7 to day 28 in the infarcted brain rogryjfubd (wviiukufmz ) View more	-	01 Feb 2019
NCT00721799 (CTgov)	Phase 2	Squamous Cell Carcinoma of Head and Neck \| Laryngeal Neoplasms \| Oropharyngeal Neoplasms \| Mouth Neoplasms	33	18F-Fluorothymidine PET scan	epqkkntmmm(zoaqhhmdqc) = gzulascgnq cfznmtzrga (ekgotsbaev, guiotxhijs - gafzchotvz) View more	-	03 Oct 2017
SNMMI2016	Not Applicable	Solitary Pulmonary Nodule	-	18F-FLT18F-FDG (18F-FLT PET/CT)	hokxqgkjhy(kjinjlajgx) = jmpetsrvbu nwucwqhltt (pkqbodmvpj ) View more	-	24 May 2016