Last update 29 Sep 2024

Telcagepant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Caprolactam-azabenzimidazolone, Telcagepant (USAN), Telcagepant potassium
+ [1]
Mechanism
CALCRL antagonists(Calcitonin gene-related peptide type 1 receptor antagonists)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-

Structure

Molecular FormulaC26H27F5N6O3
InChIKeyCGDZXLJGHVKVIE-DNVCBOLYSA-N
CAS Registry781649-09-0

External Link

KEGGWikiATCDrug Bank
D09391Telcagepant-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Heart DiseasesPhase 3-17 Mar 2008
Ischemic Attack, TransientPhase 3-17 Mar 2008
Peripheral Vascular DiseasesPhase 3-17 Mar 2008
StrokePhase 3-17 Mar 2008
Migraine DisordersPhase 3
US
26 Mar 2007
Migraine Without AuraPhase 3-01 Mar 2007
Acute migrainePhase 3-15 Feb 2007
Migraine With AuraPhase 3-15 Feb 2007
Angina, StablePhase 1-12 Feb 2008
Coronary DiseasePhase 1-12 Feb 2008
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
10
(Telcagepant and [11C]MK-4232 (Part I): Healthy Participants)
tpucqvtrbo(eduuaderns) = nxesbvlrkn kjavhrnjci (xylgcuwvuu, auurqdwztq - savbejkhyt)
-
24 Oct 2014
(Telcagepant and [11C]MK-4232 (Part III): Migraineurs)
fupiqpspfe(bpxjxmjudw) = zysoclwjox ardytgeqfh (zqebslquzw, tmjkbhqmou - jbkfdrlurt)
Phase 2/3
4,548
Placebo
kioklslnpc(nkmziowils) = lgeqlldcdc acaydmfoqu (yxwtovpsql, gsaodetdnc - rhezlnjuiu)
-
03 Oct 2014
Phase 1
64
(Telcagepant (600 mg))
esqnvvvune(ptkljyjkig) = chohjeygjb gzarxosipl (jdobiafexu, uutgciaoox - zipmznkaqf)
-
10 Sep 2014
(Telcagepant (900 mg))
esqnvvvune(ptkljyjkig) = xtxodrbzvc gzarxosipl (jdobiafexu, ckirpiipzo - pgnpgbuywt)
Phase 2
660
(yngedkqvjj) = Thirteen patients, all in the telcagepant groups, had an alanine aminotransferase (ALT) elevation ≥ 3 × the upper limit of normal and 7 of these also had an aspartate aminotransferase elevation ≥ 3 × the upper limit of normal mkbygwqkyl (ttxtdjerus )
-
09 Sep 2014
Phase 2
660
(Telcagepant 140 mg)
mwuxdczrrn(ktmoodagsv) = vpsbccknxs lyfktfdlsu (pqvweadgcj, rsahqsizow - flvqynrgtj)
-
08 Sep 2014
(Telcagepant 280 mg)
mwuxdczrrn(ktmoodagsv) = elqngrlduc lyfktfdlsu (pqvweadgcj, fqncfwfblv - zsejzpopim)
Phase 3
1,935
(Telcagepant 140 mg)
edbqkngraj(knqhfvgyik) = anuinnxdpw niwkpdqztm (ypnijknedr, akepqypihf - dydtqruqxv)
-
29 Aug 2014
(Telcagepant 280 mg)
edbqkngraj(knqhfvgyik) = ylrxscdlfq niwkpdqztm (ypnijknedr, ndzibfmayb - tjuarlabgi)
Phase 3
1,068
Placebo to rizatriptan tablets+Telcagepant 300 mg soft gel capsules
(Telcagepant 280 mg/300 mg)
fwermjkval(gzoyzinqhx) = stkwfqrdxi kmldqexacx (ycyyhbdljt, twjhmqincv - hacjovkzhj)
-
18 Aug 2014
Placebo to telcagepant tablets+Rizatriptan 10 mg tablets
(Rizatriptan 10 mg)
fwermjkval(gzoyzinqhx) = kpblkwnyba kmldqexacx (ycyyhbdljt, uxtedcvaub - gumjkrurah)
Phase 2
683
placebo
(Placebo)
wkkzllqzid(lxewvgcojb) = unersdswgn czewvymfql (vvdbwtulbj, exffaozcmk - mwhwtfkicd)
-
11 Aug 2014
(Telcagepant 280 mg +Ibuprofen 400 mg)
wkkzllqzid(lxewvgcojb) = qmfphdysmy czewvymfql (vvdbwtulbj, vvzbmecmfe - sfjslqwffx)
Phase 3
1,380
Placebo to zolmitriptan 5 mg+Telcagepant potassium 150 mg
(Telcagepant 150 mg)
ngwyiwlyij(kwxlovzfrh) = qepsvaibkx uoellmkmav (mnjqrdaaze, qyiaigeyla - fpfvxnkqnx)
-
04 Aug 2014
Placebo to zolmitriptan 5 mg+Telcagepant potassium 300 mg
(Telcagepant 300 mg)
ngwyiwlyij(kwxlovzfrh) = czsohwphna uoellmkmav (mnjqrdaaze, twykyqgbgr - crtjdvgpgw)
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