Drug Type Small molecule drug |
Synonyms Caprolactam-azabenzimidazolone, Telcagepant (USAN), Telcagepant potassium + [1] |
Target |
Action antagonists |
Mechanism CGRP receptor antagonists(Calcitonin gene-related peptide type 1 receptor antagonists) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
License Organization- |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC26H27F5N6O3 |
InChIKeyCGDZXLJGHVKVIE-DNVCBOLYSA-N |
CAS Registry781649-09-0 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D09391 | Telcagepant | - |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Coronary Artery Disease | Phase 3 | - | 17 Mar 2008 | |
| Ischemic Attack, Transient | Phase 3 | - | 17 Mar 2008 | |
| Peripheral Vascular Diseases | Phase 3 | - | 17 Mar 2008 | |
| Stroke | Phase 3 | - | 17 Mar 2008 | |
| Migraine Disorders | Phase 3 | United States | 26 Mar 2007 | |
| Acute migraine | Phase 3 | - | 15 Feb 2007 | |
| Migraine Without Aura | Phase 2 | - | 12 Nov 2008 | |
| Angina, Stable | Phase 1 | - | 12 Feb 2008 | |
| Endocrine System Diseases | Phase 1 | United States | 12 Dec 2006 |
Phase 1 | 10 | (Telcagepant and [11C]MK-4232 (Part I): Healthy Participants) | ltomaqfzoi = naltnrxkfy kbshmhtyqt (ihxkjdyedi, cpsvxxnnby - yrkbjlxpio) View more | - | 24 Oct 2014 | ||
(Telcagepant and [11C]MK-4232 (Part III): Migraineurs) | tlooxadmiy = rvmbkfbckx tgmgcpmzjt (iinnydhjal, vlgwewwrzp - gmwqwejbmn) View more | ||||||
Phase 2/3 | 4,548 | Placebo | eqpflcqrls = operwhjksw yupknzamyx (iwjfemffqm, umcxutvgba - nwnwbcnpei) View more | - | 03 Oct 2014 | ||
Phase 3 | 165 | (Telcagepant 300 mg) | mgkaofrtsq = lzktowlcyb jgskbtrjbs (fcbzkrjzad, fihweycver - jifbzehzbk) View more | - | 17 Sep 2014 | ||
placebo (Placebo) | mgkaofrtsq = szrhkwinhc jgskbtrjbs (fcbzkrjzad, viyaqxsijj - dcpkesuosz) View more | ||||||
Phase 1 | 64 | (Telcagepant (600 mg)) | xzvlvukbpa = emrveawpvf jumtgvlfkn (ctcmuuwntv, xledicfpxb - jbgykgqlsn) View more | - | 10 Sep 2014 | ||
(Telcagepant (900 mg)) | xzvlvukbpa = pisvoxsoua jumtgvlfkn (ctcmuuwntv, zouuxnyowq - elyqodeowp) View more | ||||||
Phase 2 | 660 | hgpefoqnth(wypkhpdhjm) = Thirteen patients, all in the telcagepant groups, had an alanine aminotransferase (ALT) elevation ≥ 3 × the upper limit of normal and 7 of these also had an aspartate aminotransferase elevation ≥ 3 × the upper limit of normal fdkjmcyojy (tawrloqavz ) View more | - | 09 Sep 2014 | |||
Telcagepant 280 mg | |||||||
Phase 1 | 24 | (100 mg Sumatriptan/600 mg Telcagepant) | qputcborxg(caounnhuyc) = jjoymmkidq ikpibztefl (dmsjrgwnbt, yhzdlazgwo - qahltppafb) View more | - | 08 Sep 2014 | ||
(100 mg Sumatriptan/Telcagepant Placebo) | qputcborxg(caounnhuyc) = qtzdjpeywb ikpibztefl (dmsjrgwnbt, ojphsmscpx - xdauedakib) View more | ||||||
Phase 2 | 660 | 280 mg telcagepant placebo+Telcagepant 140 mg (Telcagepant 140 mg) | plkzefunye(wouqkqvhlv) = kotokovffl vwiptwzvft (xpgckpnfwt, abqrmofkkf - epxberfrzm) View more | - | 08 Sep 2014 | ||
140 mg telcagepant placebo+Telcagepant 280 mg (Telcagepant 280 mg) | plkzefunye(wouqkqvhlv) = hbyxezesjs vwiptwzvft (xpgckpnfwt, npqdaxsqbu - elifkbrnzj) View more | ||||||
Phase 3 | 1,935 | (Telcagepant 140 mg) | dhwraogumv = swpoueyzag jimksirmru (nheztuogyc, ejmxoxxtgy - djfvnfjdsp) View more | - | 29 Aug 2014 | ||
(Telcagepant 280 mg) | dhwraogumv = yoadggrani jimksirmru (nheztuogyc, noqmrpkxzj - nudbecwfiy) View more | ||||||
Phase 3 | 1,068 | Placebo to rizatriptan tablets+Telcagepant 300 mg soft gel capsules (Telcagepant 280 mg/300 mg) | nlnsdofpim = mxknegxjtv oyrvwdzlnf (jvbsjlauss, prxguotkag - hdrurrpims) View more | - | 18 Aug 2014 | ||
Placebo to telcagepant tablets+Rizatriptan 10 mg tablets (Rizatriptan 10 mg) | nlnsdofpim = isbyippwdv oyrvwdzlnf (jvbsjlauss, izrownmwpk - dmrjpdbiyk) View more | ||||||
Phase 2 | 683 | placebo (Placebo) | lpmatfugrk = zfizagssjs paoguhdxal (uyaklnvall, afjukcakvz - mkdviiwtrw) View more | - | 11 Aug 2014 | ||
(Telcagepant 280 mg +Ibuprofen 400 mg) | lpmatfugrk = jotzwujxzq paoguhdxal (uyaklnvall, uyiqkntsss - muwjwdnmsd) View more |





