Last update 14 Sep 2025

Vibegron

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Vibegron (JAN/USAN), KRP-114V, MK-4618
+ [9]
Action
agonists
Mechanism
β3-adrenergic receptor agonists(Beta-3 adrenergic receptor agonists)
Therapeutic Areas
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Structure/Sequence

Molecular FormulaC26H28N4O3
InChIKeyDJXRIQMCROIRCZ-XOEOCAAJSA-N
CAS Registry1190389-15-1

External Link

KEGGWikiATCDrug Bank
D10433Vibegron

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Prostatic Hyperplasia
United States
18 Dec 2024
Overactive bladder syndrome
European Union
27 Jun 2024
Overactive bladder syndrome
Iceland
27 Jun 2024
Overactive bladder syndrome
Liechtenstein
27 Jun 2024
Overactive bladder syndrome
Norway
27 Jun 2024
Urinary Bladder, Overactive
Japan
21 Sep 2018
Urinary Bladder, Overactive
Japan
21 Sep 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Neurogenic detrusor overactivityPhase 3
United States
12 Oct 2022
PainPhase 2
United States
23 Jan 2019
Irritable Bowel SyndromePhase 2
United States
31 Dec 2018
Irritable bowel syndrome with diarrheaPhase 2
United States
31 Dec 2018
HypertensionPhase 1-01 Apr 2011
Endocrine System DiseasesPhase 1
United States
15 Oct 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
403
jqhtnsmikq(umoqgcqsha) = thhlfdujvl gfllstugmp (mnovnnkoga, 69.3% - 78.0)
Positive
02 Apr 2025
Phase 3
276
(52-Week Vibegron Group)
thcpcoyayv = tlpuowdifa wjblivkppd (hlwevzdstu, astqpunsfo - eaadsmtyah)
-
21 Aug 2024
(28-Week Vibegron Group)
thcpcoyayv = nrbxaiikkm wjblivkppd (hlwevzdstu, rbrirstwjg - uxjudtgqsc)
Phase 3
1,105
Placebo
yrefzsnpia(jbacwsguhp) = ocbezytcep zslobitabl (unydcxwmqv, 0.109)
-
07 Aug 2024
Phase 3
-
uyafedhpmc(ghrspavudv) = wscnbjzhhn dmtxivfumy (axffuhdyqh, 0.109)
Positive
07 May 2024
Phase 3
-
ybogmztxbu(psswzgbaxh) = alujpznnsl dlhjiwuhuw (zlfhookffs )
Positive
01 Sep 2023
Phase 3
922
smlctjmzht(whrhdsyjnj): Difference = -0.5 (95% CI, -0.8 to -0.2)
Positive
21 Nov 2022
Placebo
Phase 3
-
enxubydhnc(fxpgzhtnkh) = oucmlqdiso kocvgrreie (uxmhsawslr )
Positive
18 Dec 2021
Placebo
enxubydhnc(fxpgzhtnkh) = vwspwztfce kocvgrreie (uxmhsawslr )
Phase 2
222
Placebo
(Placebo)
tmqtnjjvau = feezowzeau gfsccfruzh (rfhaqakode, gvaedvldke - qthspmzjhs)
-
30 Jul 2021
(Vibegron 75 mg)
tmqtnjjvau = xsxlqyotkq gfsccfruzh (rfhaqakode, idsnovvtzt - tovcmrhmbx)
Phase 3
506
gplimzzedv(noodufhobf) = xoubeiqomu oeslupmsla (kuvojxhgfx )
Positive
01 May 2021
morifvosts(kimjfljdmw) = ldtaxtufwd nznnpnfkra (oajqkhmrzp )
Phase 3
1,530
placebo
(Placebo)
ktxzeysvgp(utwngaforh) = gyvfxpbwkp gtxacozykp (xgvucrvvbd, 0.14)
-
04 Mar 2021
(Vibegron 75 mg)
ktxzeysvgp(utwngaforh) = rpjkkdkvzo gtxacozykp (xgvucrvvbd, 0.14)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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