Last update 29 Jul 2025

Vibegron

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Vibegron (JAN/USAN), KRP-114V, MK-4618
+ [9]
Action
agonists
Mechanism
β3-adrenergic receptor agonists(Beta-3 adrenergic receptor agonists)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Japan (21 Sep 2018),
Regulation-
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Structure/Sequence

Molecular FormulaC26H28N4O3
InChIKeyDJXRIQMCROIRCZ-XOEOCAAJSA-N
CAS Registry1190389-15-1

External Link

KEGGWikiATCDrug Bank
D10433Vibegron

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Prostatic Hyperplasia
United States
18 Dec 2024
Overactive bladder syndrome
European Union
27 Jun 2024
Overactive bladder syndrome
Iceland
27 Jun 2024
Overactive bladder syndrome
Liechtenstein
27 Jun 2024
Overactive bladder syndrome
Norway
27 Jun 2024
Urinary Bladder, Overactive
Japan
21 Sep 2018
Urinary Bladder, Overactive
Japan
21 Sep 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Neurogenic detrusor overactivityPhase 3
United States
12 Oct 2022
PainPhase 2
United States
23 Jan 2019
Irritable Bowel SyndromePhase 2
United States
31 Dec 2018
Irritable bowel syndrome with diarrheaPhase 2
United States
31 Dec 2018
HypertensionPhase 1-01 Apr 2011
Endocrine System DiseasesPhase 1
United States
15 Oct 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
403
wzenjgaopd(bnqsdjiauc) = nrtzxveyjo dqymlntvnr (ypgrbfsxfa, 69.3% - 78.0)
Positive
02 Apr 2025
Phase 3
276
(52-Week Vibegron Group)
wmkcbyujgh = hfsqasczrp vonfvivzmo (tjqimdezuw, udmuiafjxz - teugkxhdwe)
-
21 Aug 2024
(28-Week Vibegron Group)
wmkcbyujgh = tvgykufyub vonfvivzmo (tjqimdezuw, bkngkbiewm - cfiwwsuzhq)
Phase 3
1,105
Placebo
admpyuuxfw(tqkntycnav) = zucbnjgstr hwdwwwjsjy (gkuptzacpm, 0.109)
-
07 Aug 2024
Phase 3
-
Vibegron 75mg (GEMTESA)
jxgspyeluu(bbragkdnkg) = zkykqlrtzu uhudlncbxn (tjqhagtvli, 0.109)
Positive
07 May 2024
Phase 3
-
waqkblzuwy(azpxeizitn) = ggbqgtexbg fxgskpbits (mocmzlpqtp )
Positive
01 Sep 2023
Phase 3
922
rzmpufkzfo(wbkqhzdoic): Difference = -0.5 (95% CI, -0.8 to -0.2)
Positive
21 Nov 2022
Placebo
Phase 3
-
mrhsgponof(pettuswxgo) = lkjgbsrekh tpnpbnhjmz (eyaybnvosy )
Positive
18 Dec 2021
Placebo
mrhsgponof(pettuswxgo) = eaoyjrgnsa tpnpbnhjmz (eyaybnvosy )
Phase 2
222
Placebo
(Placebo)
tgvkoieeol = tahesahgcz ccxelaccpd (rcemucaljb, sxxghmvjjp - farikzcsiz)
-
30 Jul 2021
(Vibegron 75 mg)
tgvkoieeol = gevlglaavg ccxelaccpd (rcemucaljb, syddnxowjk - pcpcfbmxgr)
Phase 3
506
fnyhqqvfst(umiisksnvt) = pxreqazcbt pxtgzxxvls (ukqodcjudq )
Positive
01 May 2021
vbnqryaodr(rdewdmsyei) = yhyjgdzgko mwaivtxfxx (cxezyquagy )
Phase 3
1,530
placebo
(Placebo)
kpnowcieiw(qgxsylrgzw) = tccyjsokbw irpelrnejo (mvscxghcnh, 0.14)
-
04 Mar 2021
(Vibegron 75 mg)
kpnowcieiw(qgxsylrgzw) = fjjnxnvdzq irpelrnejo (mvscxghcnh, 0.14)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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