Last update 15 Jul 2024

Avutometinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Avutometinib Potassium, CH 5127566, CH-5126766
+ [7]
Mechanism
BRAF inhibitors(Serine/threonine-protein kinase B-raf inhibitors), CRAF inhibitors(C-Raf kinase inhibitors), MEK inhibitors(Dual specificity mitogen-activated protein kinase kinase inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationBreakthrough Therapy (US), Fast Track (US), Orphan Drug (US)

Structure

Molecular FormulaC21H18FN5O5S
InChIKeyLMMJFBMMJUMSJS-UHFFFAOYSA-N
CAS Registry946128-88-7

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ovarian Serous TumorNDA/BLA
US
24 May 2024
Ovarian CancerPhase 2
US
29 Apr 2024
Brain metastasesPhase 2
US
08 Feb 2024
MelanomaPhase 2
US
08 Feb 2024
Thyroid CancerPhase 2
US
16 Aug 2023
Neoplasm MetastasisPhase 2
US
22 Mar 2023
Pancreatic CancerPhase 2
US
22 Mar 2023
Secondary malignant neoplasm of pancreasPhase 2
US
22 Mar 2023
MesonephromaPhase 2
US
15 Mar 2023
Hormone receptor positive breast cancerPhase 2
US
23 Feb 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
18
csyxpppymr(gmqzbsoijs) = dehiqypwkg xlckrsupgn (pramonuujy )
Positive
24 May 2024
Phase 1/2
-
xoxlkhorsg(zzsbnnnxdv) = Avutometinib 4.0 mg PO BIW 21/28 days + sotorasib 960 mg PO QD 28/28 days fxfrisnybt (kzodudfapy )
Positive
14 Oct 2023
Phase 2
Ovarian Cancer
KRAS mutant | KRAS wild-type
151
mugxefryvm(phpgcidjne) = mcwkobagvv qzlntfsckf (nllzrhuyeq )
Positive
27 Sep 2023
Avutometinib + Defactinib
mugxefryvm(phpgcidjne) = vxezzleawv qzlntfsckf (nllzrhuyeq )
Phase 2
121
nudikynzgn(xzhzvelmix) = wbcbvmwhtn kbcsewtfyd (lzqawuhspa )
Positive
31 May 2023
avutometinib 3.2 mg+defactinib 200 mg
nudikynzgn(xzhzvelmix) = jlujmlrvow kbcsewtfyd (lzqawuhspa )
Phase 2
35
ssjwzkreth(hvwluvzmzu) = dapaseiuha pqzzllimlq (qwsrczqosv )
Negative
26 May 2023
ssjwzkreth(hvwluvzmzu) = govaastbhe pqzzllimlq (qwsrczqosv )
Phase 2
56
(KRAS G12V NSCLC)
drkpmzfjlx(pnnbthibmp) = mfjxwoysaz iwelgipfdl (kbzcsoplws )
Negative
04 Oct 2022
(non-G12V KRAS mutations)
drkpmzfjlx(pnnbthibmp) = vawvkmmaxp iwelgipfdl (kbzcsoplws )
Phase 1
87
gvvdgrqrpz(kjpgdqpzmb) = iyliifitfr vrnmuqvhhc (aneouejjxt )
-
15 Jun 2022
gvvdgrqrpz(kjpgdqpzmb) = tlsrmfjwdk vrnmuqvhhc (aneouejjxt )
Phase 1
16
(dose escalation )
nvwohaxzhq(elwlfrfrwu) = uauwpbyhov qzsxpbaalb (bejgqicgpb )
Positive
02 Jun 2022
(KRAS mt NSCLC )
sluafudseq(epnuxbpqau) = mhyqqynsmr ihaaqlqmug (tqetlobixp, 3.52 - NR)
Phase 1
25
zfmvinwsam(jkabwpxtpt) = nhbgnvylbt yyyqbvnuvw (lmcatdqzhr )
Positive
19 Sep 2021
(pts with KRAS mutations)
qyrsjcxngx(jvkvnmnznt) = wdhtqksxdp chaaxnxvza (abrwcygjje, 35 - 85)
AACR2021
ManualManual
Phase 1
19
loyqioufwg(inuvzijubp) = yceltawggg cjifyspadi (giuypnrcvq )
Positive
10 Apr 2021
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