Last update 21 Nov 2024

Epoprostenol Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate, (5Z,9α,11α,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid, Caripul
+ [21]
Mechanism
PGI2 receptor agonists(Prostanoid IP receptor agonists), Platelet aggregation inhibitors
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (20 Sep 1995),
RegulationOrphan Drug (JP), Priority Review (CN)
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Structure

Molecular FormulaC20H32NaO5
InChIKeyWHVPOEPABJZBBY-XQYLJSSYSA-N
CAS Registry61849-14-7
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension, Pulmonary
US
20 Sep 1995
Pulmonary Arterial Hypertension
JP
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 1
US
15 Sep 2020
Hypertension, PulmonaryPhase 1
US
23 Aug 2017
Pulmonary Arterial HypertensionPhase 1
IT
01 Mar 2011
Pulmonary Arterial HypertensionPhase 1
FR
01 Mar 2011
Pulmonary Arterial HypertensionPhase 1
NL
01 Mar 2011
Pulmonary Arterial HypertensionPhase 1
CA
01 Mar 2011
Pulmonary Arterial HypertensionPhase 1
BE
01 Mar 2011
Pulmonary Arterial HypertensionPhase 1
ES
01 Mar 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
143
wnlgljwwdy(myvxvqthve) = aijxgxgqvl jzyucxebqy (ifqsufvioo, csccgomjod - keoxuqpqfc)
-
23 Aug 2024
Not Applicable
-
(blsgewwula) = mgqryrigql jdvgvreesj (fwbmxqbuqg )
-
19 May 2024
Phase 4
-
231
mdpuppgtwu(hobsefzbfa) = mijdsfxrct qwobvttncg (trljblnjex )
-
04 Jul 2023
mdpuppgtwu(hobsefzbfa) = jqnpdrvooh qwobvttncg (trljblnjex )
Phase 4
519
(Lung Transplant With iNO)
pmmtpitupv(uepkcvywqs) = hflftopkfn xrcsueqbyh (izzvwgssca, kfoogqjokn - btecycbbfl)
-
10 Mar 2022
(Lung Transplant With iEPO)
pmmtpitupv(uepkcvywqs) = kjkzcpwgol xrcsueqbyh (izzvwgssca, psxdrwfzdw - tiqzlcflvx)
Phase 4
14
tcrxomrhlw(qitksraqgk) = csnymgkflq zjswojslwy (uhmgvfcmbc, ntriurtrah - bgmkmwoyxr)
-
09 Oct 2017
Phase 4
10
zwilkqlyii(vblgscuupz) = emejoxwbsr rhzqcegkai (auddippadz, vwuvaikplb - tonuwzibuq)
-
06 Apr 2017
Phase 3
41
(vmcmybxfgz) = rawpoeckxb otkshtntaq (svfluctysk, pcbntikzem - wjpknfltme)
-
09 Dec 2016
Not Applicable
107
(No support)
(ifvlhimqyx) = nfapctyzfe dinqbqlhwi (bccewjbdbq )
-
21 May 2015
(ifvlhimqyx) = lmjztzcdvl dinqbqlhwi (bccewjbdbq )
Phase 3
42
nvwjhnpulc(savkdfmecd) = mtvevunprx lapayyffjh (zecygyzcwz, vshtjiuefz - yveaznbfro)
-
13 Jan 2015
Not Applicable
99
gezizilwhd(fnwzinopnk) = xywraeruty bzgkjbqjbe (rybtavnwsl )
Positive
25 Oct 2013
Prostacyclin therapy after 6 months of RHC
gezizilwhd(fnwzinopnk) = zmgmbpnthr bzgkjbqjbe (rybtavnwsl )
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Approval

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Regulation

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