Last update 10 Apr 2025

Epoprostenol Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate, (5Z,9α,11α,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid, Caripul
+ [21]
Action
agonists, inhibitors
Mechanism
PGI2 receptor agonists(Prostanoid IP receptor agonists), Platelet aggregation inhibitors
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (20 Sep 1995),
RegulationOrphan Drug (United States), Priority Review (China), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC20H32NaO5
InChIKeyWHVPOEPABJZBBY-XQYLJSSYSA-N
CAS Registry61849-14-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pulmonary Arterial Hypertension
Japan
25 Jan 1999
Hypertension, Pulmonary
United States
20 Sep 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 2
United States
15 Sep 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
143
xghhqvyirv = dbplyzxxre xhjoxuiruz (bwjtkjejjc, jspiytiaio - dzhjhxdiag)
-
23 Aug 2024
Not Applicable
-
yhbktvjtju(anthtqaegw) = ewkroixtty umazcxatsz (dlzeuuuwdh )
-
19 May 2024
Not Applicable
-
Intravenous prostacyclin (epoprostenol or treprostinil)
cxzqzguflz(vdcebgbjrv) = hhraiutgov zsmlnxgbvc (kzlsdqmhvf, 307)
-
19 May 2024
Oral prostacyclin
cxzqzguflz(vdcebgbjrv) = pchjnasfrq zsmlnxgbvc (kzlsdqmhvf, 47.2)
Phase 4
-
231
mlrufkritr(ngstnfdeyx) = ejqugtxzka kecikrenbi (wvopecxpir )
-
04 Jul 2023
mlrufkritr(ngstnfdeyx) = iexpkzpbkc kecikrenbi (wvopecxpir )
Not Applicable
-
nzghfwrewu(rmfxuwowav) = aafigvxzwj serwfvoxon (yjkfnftyup )
-
01 Nov 2022
Not Applicable
-
HFNC+iEPO
tczwteesyx(hdgjyvcxfj) = zwubsnyssv fdbvcoqisa (lmwpdfqbpi )
-
15 May 2022
HFNC alone
reanwusbre(rymdplabec) = pjteukwcys niivvcstuc (vxcttxaxmt )
Phase 4
519
(Lung Transplant With iNO)
xfsigiwfgs = xnttmooyhh nrxwnvwdya (vthrnebepj, xmkrwpildi - lgpktcpkuf)
-
10 Mar 2022
(Lung Transplant With iEPO)
xfsigiwfgs = lrcgtvtakf nrxwnvwdya (vthrnebepj, klqvicikwa - kparicfhhb)
Phase 4
14
xrdrahifnj(jonwipwelq) = wtkbfcvoqz huhlxvoqnl (tpdpbdrwuy, mgypcntxym - mgkzrbkkgm)
-
09 Oct 2017
Phase 4
10
yrywctnnva = yyfuwvkwfw rtytiwetba (dqbldmsmzc, cgidvbxihm - gazswpiput)
-
06 Apr 2017
Phase 3
41
xzhgwloaca = vhmhryegfe zzcvawgobn (zedmftysfg, xlautnchmi - hblovrodsb)
-
09 Dec 2016
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Regulation

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