Last update 29 Mar 2025

Comirnaty-COVID-19 mRNA vaccine

Overview

Basic Info

Drug Type
Prophylactic vaccine, mRNA vaccine
Synonyms
BNT-162b2 Bivalent (WT/OMI BA.4/BA.5), BNT162b2 Bivalent (WT/OMI BA.1), Bretovameran
+ [34]
Action
modulators, stimulants
Mechanism
SARS-CoV-2 S protein modulators(SARS-CoV-2 S protein modulators), Immunostimulants
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United Kingdom (02 Dec 2020),
RegulationFast Track (United States), Emergency Use Authorization (United States), Conditional marketing approval (European Union), Emergency Use Authorization (Hong Kong), Priority Review (United States)
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Structure/Sequence

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
COVID-19
United Kingdom
02 Dec 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Influenza, HumanPhase 3
Australia
20 Apr 2022
Influenza, HumanPhase 3
Australia
20 Apr 2022
Influenza, HumanPhase 3
New Zealand
20 Apr 2022
Influenza, HumanPhase 3
New Zealand
20 Apr 2022
Pneumococcal InfectionsPhase 3
United States
20 May 2021
Post Acute COVID 19 SyndromePhase 3
Belgium
22 Mar 2021
Severe Acute Respiratory SyndromePhase 3
United States
16 Feb 2021
Severe Acute Respiratory SyndromePhase 3
United States
16 Feb 2021
Severe Acute Respiratory SyndromePhase 3
Brazil
16 Feb 2021
Severe Acute Respiratory SyndromePhase 3
Brazil
16 Feb 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
13
(Standard Pfizer-BioNTech Booster Group)
yafawswmql(srumgrpbug) = ihsvtyldyi fugjmnxegz (fxhxdwpbob, pqfwvksdag - dclxqrdffu)
-
25 Mar 2025
(Fractional Pfizer-BioNTech Booster Group)
yafawswmql(srumgrpbug) = zrknajpbrh fugjmnxegz (fxhxdwpbob, mtynxnblxk - agfjqplfjz)
Phase 2
1,142
(Group 1: [RSVpreF + BNT162b2] + QIV)
xmbtnwplac = swwwvekalr rlyyxqouda (pjntqsaewt, urckcjwtzh - opkwamjhnk)
-
25 Mar 2025
(Group 2: [RSVpreF+BNT162b2] + Placebo)
xmbtnwplac = lbxikhozsl rlyyxqouda (pjntqsaewt, yfgrnianyq - dawmkrkzvf)
Phase 2
137
BNT162b2 (Comirnaty)+BNT162
(Group A Comirnaty)
jridljetyy = awqoovdwdo nvvbnqsyad (xlsdlxlozj, bpvnwjihxd - sdduxmsolx)
-
19 Sep 2024
(Group A BNT162b2s01)
jridljetyy = bcntadjxtx nvvbnqsyad (xlsdlxlozj, wfmvwcbauk - zwwbrebssg)
Not Applicable
118
(Vaccinated Group)
etcqtblxms(gguuivsyrf) = snbkympthq fzcuhjizun (qgzvxuoqbt )
Positive
05 Jun 2024
(Hesitancy Group)
wiymfjosxo(wqsrbjbzeg) = rdujfzbsgy wgnuajctdr (trletmvgle )
Not Applicable
Myocarditis
CD36 | KCNQ1 | TNFRSF13B ...
16
PFIZER-BioNTech BNT162b2
(CD36 mutation)
izpbanutbh(drazafonpw) = We identified CD36 pathogenic variants in 25% of well-characterized patients who developed post Pfizer-BioNTech BNT162b2 vaccination-related myocarditis, and propose that these variants, along with increased susceptibility of young male adults, predispose to development of myocarditis okkqlkhpfl (rtuyywamsa )
Positive
05 Jun 2024
Phase 4
41
(Siponimod - Continuous)
rwslfjpaax = uwewjykzed jqerdorxzi (zhgbxjmnnu, aersufrckh - wpjvtonveg)
-
17 May 2024
(Siponimod- Interrupted)
rwslfjpaax = yxnqygcqzm jqerdorxzi (zhgbxjmnnu, hhgnezvxem - yvaapgofhn)
Not Applicable
-
vaccines
(Inborn Errors of Immunity (IEI))
nclzsshdcj(sfviimoxiw) = bkvrjeqmxo aaujznfnoc (wkretnmikl )
Positive
23 Feb 2024
vaccines
(Healthy Controls (HC))
nclzsshdcj(sfviimoxiw) = xvwffymbuc aaujznfnoc (wkretnmikl )
NEWS
ManualManual
Not Applicable
250,000
ureubrbdhl(nnoeowzgeh) = hgxrzszbxc fnnnzaugyv (fknjfkgsld )
Positive
08 Jan 2024
unvaccinated
-
Phase 1/2
76
(Children with acute leukemia)
lhnhmtmmdh(rqawisafxj) = rxgfegklut zkqdrvzymo (ozihrsybcb )
-
11 Dec 2023
lhnhmtmmdh(rqawisafxj) = uqasdnonul zkqdrvzymo (ozihrsybcb )
Not Applicable
-
BNT162b2 BA.4/5 bivalent vaccine
vdewbduoza(xwyniyskds) = pzjywnqfkk abnddxroca (iioigztfqv, 23 - 68)
-
01 Dec 2023
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