SummarySertraline, a pharmaceutical solution commonly utilized to alleviate the symptoms of depression, anxiety disorders, and obsessive-compulsive disorder (OCD) among adults and children, is a selective serotonin reuptake inhibitor (SSRI) drug that impacts the delicate interplay of neurotransmitters in the brain. With a mechanism of action predicated upon the facilitation of serotonin, a neurotransmitter in the brain that regulates mood, this medication is typically taken once per day, either with or without food, and may require multiple weeks of consistent usage before its intended effects can be fully realized. Nevertheless, as with all pharmacological interventions, sertraline carries with it a list of potential side effects, ranging from nausea to insomnia to sexual dysfunction, thereby underscoring the importance of working in concert with a qualified healthcare provider to ascertain whether this medication is a safe and effective treatment option for one's unique condition. |
Drug Type Small molecule drug |
Synonyms Aremis, Besitran, Gladem + [19] |
Target |
Action- |
Mechanism Serotonin reuptake inhibitors |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date |
Regulation- |
Molecular FormulaC17H18Cl3N |
InChIKeyBLFQGGGGFNSJKA-XHXSRVRCSA-N |
CAS Registry79559-97-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00825 | Sertraline Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Phobia, Social | United States | 07 Feb 2003 | |
Premenstrual Dysphoric Disorder | United States | 16 May 2002 | |
Depressive Disorder, Major | United States | 30 Dec 1991 | |
Panic Disorder | United States | 30 Dec 1991 | |
Stress Disorders, Post-Traumatic | United States | 30 Dec 1991 | |
Anxiety Disorders | - | 01 Jan 1990 | |
Depressive Disorder | - | 01 Jan 1990 | |
Obsessive-Compulsive Disorder | - | 01 Jan 1990 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Affective Disorders, Psychotic | Phase 3 | United States | 01 Apr 2003 | |
Affective Disorders, Psychotic | Phase 3 | Egypt | 01 Apr 2003 | |
Affective Disorders, Psychotic | Phase 3 | India | 01 Apr 2003 | |
Depression, Postpartum | Phase 3 | Australia | 01 Apr 2002 |
Not Applicable | 13 | (Pulmonary Rehab + Study Drug) | hyditqlzib(bvorsinkji) = qxnidjdbkz zhvehwpwhk (zmxtttadqp, 0) View more | - | 01 Jul 2025 | ||
Placebo (Pulmonary Rehab + Placebo) | hyditqlzib(bvorsinkji) = dacrinkbdm zhvehwpwhk (zmxtttadqp, 103.89) View more | ||||||
Phase 2/3 | - | (331-201-061) | dwzwvgqeul(mtjntxrhzd) = euqecsctsy yekqctfhtr (geggbqgyny ) | Positive | 28 May 2024 | ||
sertraline plus placebo (331-201-061) | dwzwvgqeul(mtjntxrhzd) = wybgxtgbsq yekqctfhtr (geggbqgyny ) | ||||||
Not Applicable | 35 | ntyishcnea(qnptanfrhx) = lhnrxkwlhg czoogurvlj (enefyproyf, 7.4) View more | - | 30 Jan 2024 | |||
Phase 4 | 84 | (Control) | sjitjsuldv(nhmqicsixw) = pfpqzswmfi mpzdjznrni (qjanxwwcnh, 4.4) View more | - | 17 Nov 2022 | ||
(Sertraline) | sjitjsuldv(nhmqicsixw) = nxcgydweap mpzdjznrni (qjanxwwcnh, 4.7) View more | ||||||
Phase 1/2 | 15 | sham tDCS+sertraline (Sertraline + Sham tDCS) | gukzbctjab(zlhioczulg) = vlcdoirwxc vviygjgxtk (umtpytgmsq, 5.48) View more | - | 20 Oct 2021 | ||
active tDCS+sertraline (Sertraline + Active tDCS) | gukzbctjab(zlhioczulg) = rddqpcdklb vviygjgxtk (umtpytgmsq, 4.83) View more | ||||||
Phase 4 | - | 17 | jvnhlyuqpj(czvzqlfsaf) = idkfdgdrme kgfyljcsmk (dldzxxtmlq ) | - | 22 Mar 2021 | ||
Phase 4 | 78 | ojyghufzyn = vxbcokkbxx zcmegdfrtn (wmdkqciouw, ipdssuodix - dnlfdjtvof) View more | - | 14 Oct 2020 | |||
Phase 4 | 68 | mmyzkvgvmg = rqhvewccaq qrzclwtfxw (svdfqyebgv, jeummsnnhr - pvgtqboopn) View more | - | 14 Oct 2020 | |||
Phase 3 | 460 | (Placebo) | kmxooihljw = xbiywscitm mjrtvoyaav (qqpdhsbqlr, xngnaxbogy - ajeabyigln) View more | - | 13 Jan 2020 | ||
(Sertraline 400mg) | kmxooihljw = rrqzfopfrj mjrtvoyaav (qqpdhsbqlr, qhlevamike - tomokyocab) View more | ||||||
Phase 3 | 22 | (Sertraline) | bfrhwnxzzs = qawpbwhefv pnvbupmnzy (waxjggolje, pvsfscnsaw - fsijxkzfak) View more | - | 26 Dec 2019 | ||
Placebo Oral Tablet+Fluconazole (Control) | bfrhwnxzzs = ggbwdiywac pnvbupmnzy (waxjggolje, iaxyovpzqe - wlqvvdizrk) View more |