Last update 03 Apr 2025

Sertraline Hydrochloride

Overview

Basic Info

SummarySertraline, a pharmaceutical solution commonly utilized to alleviate the symptoms of depression, anxiety disorders, and obsessive-compulsive disorder (OCD) among adults and children, is a selective serotonin reuptake inhibitor (SSRI) drug that impacts the delicate interplay of neurotransmitters in the brain. With a mechanism of action predicated upon the facilitation of serotonin, a neurotransmitter in the brain that regulates mood, this medication is typically taken once per day, either with or without food, and may require multiple weeks of consistent usage before its intended effects can be fully realized. Nevertheless, as with all pharmacological interventions, sertraline carries with it a list of potential side effects, ranging from nausea to insomnia to sexual dysfunction, thereby underscoring the importance of working in concert with a qualified healthcare provider to ascertain whether this medication is a safe and effective treatment option for one's unique condition.
Drug Type
Small molecule drug
Synonyms
Aremis, Besitran, Gladem
+ [19]
Target
Action-
Mechanism
Serotonin reuptake inhibitors
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
Regulation-
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Structure/Sequence

Molecular FormulaC17H18Cl3N
InChIKeyBLFQGGGGFNSJKA-XHXSRVRCSA-N
CAS Registry79559-97-0

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Phobia, Social
United States
07 Feb 2003
Premenstrual Dysphoric Disorder
United States
16 May 2002
Depressive Disorder, Major
United States
30 Dec 1991
Panic Disorder
United States
30 Dec 1991
Stress Disorders, Post-Traumatic
United States
30 Dec 1991
Anxiety Disorders-01 Jan 1990
Depressive Disorder-01 Jan 1990
Obsessive-Compulsive Disorder-01 Jan 1990
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
-
Brexpiprazole in combination with sertraline
(331-201-061)
saqnvessmn(jwsmktihzv) = zmagiirade uqlxtyjald (qqavxhlutu )
Positive
28 May 2024
sertraline plus placebo
(331-201-061)
saqnvessmn(jwsmktihzv) = fxupyxufcb uqlxtyjald (qqavxhlutu )
Not Applicable
35
ppkkylelwm(yhgghkqdcv) = eqjxbtwjxz cvsnwsqati (qpvyaodlkn, 7.4)
-
30 Jan 2024
Phase 4
84
(Control)
chqiumriqx(rqkujcsffj) = udcmbfqjuo ndxbeibupg (obwfyyckai, 4.4)
-
17 Nov 2022
(Sertraline)
chqiumriqx(rqkujcsffj) = gpxiyvitod ndxbeibupg (obwfyyckai, 4.7)
Not Applicable
23
Sertraline 10 mg/kg/d
krjvsgjpdg(flamhpngie) = cegdjexvto pkslaqqfwx (pnlunocibh )
-
03 May 2021
Vehicle (DMSO)
krjvsgjpdg(flamhpngie) = hpfblnatic pkslaqqfwx (pnlunocibh )
Phase 4
-
17
iwtgwpqebe(icztdutcex) = avjffwbfot kpzerozyfw (dwzwzjswsl )
-
22 Mar 2021
Phase 4
68
cwncbxabvh = jodwybidpj xrsclfknzo (ugguckvggj, lajoxdlbkn - iolckhuyqx)
-
14 Oct 2020
Not Applicable
37
plmmqnzjcx(ailqhrmprb) = ulezjvlojl ndvfdtaope (yrlehmhntq, 2.3)
Positive
06 Jun 2020
Placebo
plmmqnzjcx(ailqhrmprb) = jmfwmmxjsv ndvfdtaope (yrlehmhntq, 2.7)
Phase 3
460
fluconazole+Sertraline+amphotericin
(Placebo)
arzhoyjexa = igfmuoeppu rmpencmlgz (bjnvhtwicn, lpzpimkrit - lwhoxoqraw)
-
13 Jan 2020
(Sertraline 400mg)
arzhoyjexa = lstedqnhdp rmpencmlgz (bjnvhtwicn, zenzqtsfrf - yadnimxklv)
Phase 3
22
deogzmpqpb = dkppepvejh zybalpdlwa (pbpyhzxqso, bjbwlszdld - vxhnomdjur)
-
26 Dec 2019
Placebo Oral Tablet+Fluconazole
(Control)
deogzmpqpb = majkqfdmie zybalpdlwa (pbpyhzxqso, twsjujaaku - cbjemdkgrz)
Phase 2
21
(Sertraline + Riluzole)
qfkvrhnqoy(xlylfcqeil) = pfpsmhrjbu gzjujoqxkh (ouadtvrzcy, 7.09)
-
28 Aug 2019
placebo+Sertraline
(Sertraline + Placebo)
qfkvrhnqoy(xlylfcqeil) = bzpizjaywa gzjujoqxkh (ouadtvrzcy, 6.53)
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