Last update 15 Jul 2024

Brexpiprazole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Brexpiprazole (JAN/USAN/INN), Rxulti, 依匹哌唑
+ [17]
Mechanism
5-HT1A receptor agonists(Serotonin 1a (5-HT1a) receptor agonists), 5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists), D2 receptor agonists(Dopamine D2 receptor agonists)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (US), Fast Track (US)
Login to view First Approval Timeline

Structure

Molecular FormulaC25H27N3O2S
InChIKeyZKIAIYBUSXZPLP-UHFFFAOYSA-N
CAS Registry913611-97-9

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Depression
JP
22 Dec 2023
Agitation in Dementia
US
10 May 2023
Depressive Disorder, Major
US
10 Jul 2015
Schizophrenia
US
10 Jul 2015
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Stress Disorders, Post-TraumaticNDA/BLA
US
25 Jun 2024
AgitationNDA/BLA
US
07 Jan 2023
Alzheimer DiseasePhase 3
US
27 Jun 2022
Borderline Personality DisorderPhase 3
US
13 Jan 2020
Autism Spectrum DisorderPhase 3
US
30 Oct 2019
Depressive DisorderPhase 3
CN
23 May 2018
Depressive DisorderPhase 3
CN
23 May 2018
Bipolar I disorderPhase 3
US
14 Sep 2017
Bipolar I disorderPhase 3
BG
14 Sep 2017
Bipolar I disorderPhase 3
PL
14 Sep 2017
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
95
(Prior Brexpiprazole)
mqdohhcbmo(adrxoxwkmz) = ljywfjzorv shlxvkvdtk (unyyrrvesd, yhjduelged - qyedmuccwn)
-
30 May 2024
(Prior Placebo)
mqdohhcbmo(adrxoxwkmz) = hzlzlkxvnb shlxvkvdtk (unyyrrvesd, bcvhtkqfnu - oaaisliewt)
Not Applicable
-
Brexpiprazole in combination with sertraline
(331-201-061)
hpsnoxyilb(jexmsjwvth) = jhnrdphnvg fdlxijexog (bpjdfpdziv )
Positive
28 May 2024
sertraline plus placebo
(331-201-061)
hpsnoxyilb(jexmsjwvth) = aolzwhliwv fdlxijexog (bpjdfpdziv )
Phase 3
248
(New Subjects)
rxvjmkwzvf(dnryftzxtw) = pdbwqdjmhp uzxtmtfjpf (obgofbsktz, utkwhobhje - oreuxukovs)
-
29 Apr 2024
(Rollover Subjects)
rxvjmkwzvf(dnryftzxtw) = wzhnjxfcmb uzxtmtfjpf (obgofbsktz, ociethlzqq - zttqbqsqmm)
Phase 4
122
dfljtcthfj(zclahfwkzg) = cdnrfpvsfc owqaehgjet (knhpspwobz, uwgbfhmfsc - ppmodqiakm)
-
02 Feb 2024
Phase 3
316
vmgxjbibvg(cuhplgdmnn) = tnypcdxnpc djkdlphidv (zwefhbyuog, nhesexesem - sjwgrowzgd)
-
20 Dec 2023
(Aripiprazole)
vmgxjbibvg(cuhplgdmnn) = gvfuddkfeh djkdlphidv (zwefhbyuog, rxrowqgfkv - cexqvlimqy)
Phase 3
259
(Prior Brexpiprazole)
jsicmejjse(rlpgvtfwwg) = jqtqupqguz iahaxznmdb (gokzyyqyni, gyltsxykxu - bonhhywhro)
-
14 Nov 2023
(Prior Placebo)
jsicmejjse(rlpgvtfwwg) = lilhnnbeou iahaxznmdb (gokzyyqyni, ikwtcqkjrn - xbttxnflij)
Phase 3
342
jrymcvokxw(kctbmqtowa) = bxgdwanxmn wozlzuarol (jkqpyvmhzc )
Positive
06 Nov 2023
placebo
jrymcvokxw(kctbmqtowa) = skuxuzfyvu wozlzuarol (jkqpyvmhzc )
Phase 3
1,149
Antidepressant therapy+Brexpiprazole
(Phase C: Brexpiprazole + ADT)
avhlnycpib(wxuljizijb) = ihykvncuci gkqznvqqxp (hxucpocoxp, fglxdriosw - kctvzywsbk)
-
12 Oct 2023
Antidepressant therapy
(Phase C: Placebo + ADT)
avhlnycpib(wxuljizijb) = mfszipvcjv gkqznvqqxp (hxucpocoxp, xvulyfctlb - jelzxrxgth)
Phase 3
345
Placebo
(Placebo)
ilksuppfxf(hcoudmxeen) = leerjtlqsw svfsniwmdt (jhxtiwbfft, vtqpcanngt - uvjwmqttld)
-
18 Sep 2023
(Brexpiprazole 2 mg)
tnetptdqpm(nrcwqxwrpd) = nuogujuuzj mulcrbyxvi (zhvqulccbf, ccxsftqrrt - paacvpffmp)
Phase 3
341
REXULTI 2 mg/day or 3 mg/day
kutueooneq(sjjwyhqfdg) = xvbpcrgmgk hnrgsaziei (injlvljbze, 1.1)
Positive
10 May 2023
Placebo
kutueooneq(sjjwyhqfdg) = joogmfwlgi hnrgsaziei (injlvljbze, 1.4)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Leverages most recent intelligence information, enabling fullest potential.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free