SummaryNortriptyline, a monoamine reuptake inhibitor, is a small molecule drug that exhibits its pharmacological action by targeting MATs. Eli Lilly, the pharmaceutical conglomerate, was the developer of this drug which, after a rigorous testing phase, received the green light for treating depressive disorder in November 1964. Nortriptyline belongs to the tricyclic antidepressant family and operates by bolstering the levels of neurotransmitters, such as serotonin and norepinephrine, within the brain. The drug performs its depression-fighting functions by inhibiting their reuptake, hence resulting in the alleviation of symptoms such as low mood, lack of energy and motivation, and disrupted sleep. |
Drug Type Small molecule drug |
Synonyms 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine, Demethylamitriptyline + [11] |
Target |
Mechanism Monoamine reuptake inhibitor |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (06 Nov 1964), |
Regulation- |
Molecular FormulaC19H22ClN |
InChIKeySHAYBENGXDALFF-UHFFFAOYSA-N |
CAS Registry894-71-3 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00816 | Nortriptyline Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Depressive Disorder, Major | AU | 02 Apr 2015 | |
Depressive Disorder | US | 06 Nov 1964 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Gastroparesis | Phase 3 | US | 01 Jan 2009 | |
Psoriasis | Phase 2 | DE | 01 Nov 2007 | |
Small Cell Carcinoma | Phase 1 | US | 03 Nov 2016 | |
Small cell lung cancer recurrent | Phase 1 | US | 03 Nov 2016 |
Phase 4 | 742 | (Aripiprazole Augmentation) | stuzwijbbk(ceqscnxvvt) = oshxnilusk ejazkfvzmr (qqdtrrljoc, rwjzjuxatw - wnlqusasnv) View more | - | 24 May 2022 | ||
(Bupropion Augmentation) | stuzwijbbk(ceqscnxvvt) = vqxxusodph ejazkfvzmr (qqdtrrljoc, tyaoodomov - mfjdqwfrkx) View more | ||||||
Not Applicable | 35 | (Nortriptyline) | mykmkqyqwl(vlrgrgcqkb) = xrmzkaoers isbqhtysph (umigtgnsgh, nigdlxaitc - qyvrpbmaza) View more | - | 23 Apr 2021 | ||
(Topiramate) | mykmkqyqwl(vlrgrgcqkb) = xudacumvjo isbqhtysph (umigtgnsgh, hmjpowpxdn - qaevscrdrg) View more | ||||||
Phase 4 | 78 | crgtwtsngw(tyubljlutb) = hykmwzgpbx ssgcpfwray (vpeezakgkn, eztbrtbzqo - cnwftexwtl) View more | - | 14 Oct 2020 | |||
Phase 4 | 68 | hwvuqmagjq(rvezfadncu) = ruvkgmuckx mxzxtvuhea (ultishbehf, ipculowgsc - pfrntymebk) View more | - | 14 Oct 2020 | |||
Not Applicable | - | acngeufido(ucatkdbqkq) = Eight patients (25.0%) had to discontinue treatment after 7.63 ± 5.71 months due to persistent mild side effects, despite improvement in pain by 22.4% vbzmqxrvyb (epddabxiiu ) | Positive | 12 Oct 2019 | |||
Phase 4 | 402 | (Nortriptyline) | avepabelbn(vtvfmpwnsx) = cgehlqssuo vlxlbfxuai (vggdojuawv, pgttripfvm - pwvmlhwqmm) View more | - | 06 Jul 2018 | ||
(Duloxetine) | avepabelbn(vtvfmpwnsx) = tszzynkczo vlxlbfxuai (vggdojuawv, ixoyeowugx - fjlahhimjc) View more | ||||||
Phase 2 | 140 | (Nortriptyline Oral Capsule/CBT) | wpctweafsm(tenvqlyqou) = vvbqaxarwk uvzwhdxoqs (yzjxrkjhbm, yywwkfmciw - bdabollnvf) View more | - | 24 Jul 2017 | ||
(Benztropine Oral Product/CBT) | wpctweafsm(tenvqlyqou) = dnckdpyztw uvzwhdxoqs (yzjxrkjhbm, omqtjbzsht - wqylhyftlb) View more | ||||||
Not Applicable | 259 | Lumbar epidural injection+nortriptyline+acetaminophen+diclofenac+misoprostol+duloxetine+celecoxib+gabapentin+tramadol+sertraline+mirtazapine+ibuprofen+trazodone (Medical Care) | ekabkndwpz(xwijxhgxrh) = nprpdphmsc vqdevgtqjh (awquwzwbvt, oyxrcshydw - xbfogbqckm) View more | - | 17 May 2017 | ||
Group Exercise: community setting (Group Exercise) | ekabkndwpz(xwijxhgxrh) = ljavxjkqcf vqdevgtqjh (awquwzwbvt, esweuvutpv - vkfhuhlxfy) View more | ||||||
Not Applicable | - | fglxkjltzf(zlpvqyxthi) = Combination treatment resulted in moderate-severe constipation in 43% vs 46% with morphine yndrsfkbfb (penfulvjpp ) View more | Positive | 01 Aug 2015 | |||
Phase 4 | 110 | (Sertaline) | msmngrjrei(gxgmdsirli) = nouzuxnzky eaqparfvze (sjxhkdjgdc, ekvgmqmjgb - ppyzlqwvfa) View more | - | 21 Apr 2015 | ||
(Nortriptyline) | msmngrjrei(gxgmdsirli) = tzsjzvimye eaqparfvze (sjxhkdjgdc, tchfyriydp - dftrtogdtb) View more |