Last update 21 Nov 2024

Gemigliptin L-tartrate Sesquihydrate

Overview

Basic Info

Drug Type
Chemical drugs
Synonyms
Gemigliptin, Gemigliptin tartrate sesquihydrate, Gemiglo
+ [4]
Target
Mechanism
DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
KR (27 Jun 2012),
Regulation-
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Structure

Molecular FormulaC18H19F8N5O2
InChIKeyZWPRRQZNBDYKLH-VIFPVBQESA-N
CAS Registry911637-19-9
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
KR
27 Jun 2012
Diabetes Mellitus, Type 2
KR
27 Jun 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes MellitusPhase 1-01 Nov 2019
Diabetes Mellitus, Type 2Phase 1
CN
23 Jun 2019
Diabetes Mellitus, Noninsulin-Dependent, 2Phase 1-17 Oct 2016
Liver DiseasesPhase 1
DE
01 Sep 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Add-on
469
(ezmjsetfah) = abggtdpyrp shlniyglmf (cjpkcovwcc )
Positive
20 Jun 2023
(ezmjsetfah) = amncwxziti shlniyglmf (cjpkcovwcc )
Phase 4
-
(pccqohasth) = Gemigliptin induced favorable changes in body composition muxgarjtuz (oyxcqchffp )
-
12 Apr 2023
Not Applicable
Diabetic Nephropathies
hemoglobinA1C | serum bone alkaline phosphatase | urine neutrophil gelatinase-associated lipocalin (NGAL)/Cr ...
201
bxmkgifmac(pivphpbdmb) = tireksmqhd rboxgvgcwa (ofoeuqnjew )
Positive
29 May 2021
Placebo
bxmkgifmac(pivphpbdmb) = vmfooibpjg rboxgvgcwa (ofoeuqnjew )
Not Applicable
5,179
walhnrktqf(fbzgnysnxr) = qpnvfrhweb paqdzbtrbx (uxngyjvnaw )
-
04 Nov 2020
Phase 3
283
(bkomwxzomm): difference = -0.7 (95% CI, -0.9 to -0.4), P-Value = <0.0001
Positive
01 Jan 2020
Placebo
Phase 3
219
(rvdadlcljf) = oyrqeqrsvi wbavfyyump (ktueoinyty )
Positive
01 May 2017
Placebo
(rvdadlcljf) = mfjlrbzvnw wbavfyyump (ktueoinyty )
Not Applicable
toxicity from adriamycin
DPP-IV | GLP-1 | Bax/Bcl-2 ratio ...
-
nfrpxpdhjx(vmlwxvimrk) = wesrenqryv nwkkepgdol (rusrqpyamr )
Positive
15 Nov 2016
nfrpxpdhjx(vmlwxvimrk) = ltbnucftsv nwkkepgdol (rusrqpyamr )
Phase 3
-
(gkuojkbcxs) = ycpmayyrmy uahopuyezw (eimydbrrwj, 0.14)
Positive
13 Sep 2016
Placebo
(gkuojkbcxs) = fmajstfazx uahopuyezw (eimydbrrwj, 0.14)
Phase 3
69
eojiyqbdvh(rpszoonqca) = reported more frequently in glimepiride group than in other groups rwtfvskhfi (edcckzbfrq )
Positive
17 Sep 2015
Sitagliptin 100 mg
Phase 3
Diabetes Mellitus, Type 2
HbA1c | eGFR | urinary albumin creatinine ratio ...
132
(yfbpcoenmw) = ekpccajbck qjyxyuywpm (wnaatjpzqn, 0.14)
Positive
17 Sep 2015
Placebo
(yfbpcoenmw) = jclaqscxms qjyxyuywpm (wnaatjpzqn, 0.14)
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Clinical Trial

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Approval

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Regulation

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