Last update 06 Dec 2024

Gemigliptin L-tartrate Sesquihydrate

Overview

Basic Info

Drug Type
Chemical drugs
Synonyms
Gemigliptin, Gemigliptin tartrate sesquihydrate, Gemiglo
+ [4]
Target
Mechanism
DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
KR (27 Jun 2012),
Regulation-
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Structure

Molecular FormulaC44H56F16N10O19
InChIKeyWVZSXKFQIVMBIP-SQYFXPODSA-N
CAS Registry1375415-82-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
KR
27 Jun 2012
Diabetes Mellitus, Type 2
KR
27 Jun 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Noninsulin-Dependent, 2Phase 3-17 Oct 2016
Diabetes MellitusPhase 1-01 Nov 2019
Liver DiseasesPhase 1
DE
01 Sep 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Add-on
469
bfnwnrusxr(dxbpzfvxbf) = nelgpefaoy toigbpgtev (yrwfilpmbl )
Positive
20 Jun 2023
bfnwnrusxr(dxbpzfvxbf) = tegefhvzry toigbpgtev (yrwfilpmbl )
Phase 4
-
ihlkejecst(lhrhbdajuo) = Gemigliptin induced favorable changes in body composition jylnqjepsk (qlluxcajah )
-
12 Apr 2023
Not Applicable
Diabetic Nephropathies
hemoglobinA1C | serum bone alkaline phosphatase | urine neutrophil gelatinase-associated lipocalin (NGAL)/Cr ...
201
gwztoerbjd(onkkxkdrty) = nyavidmpak qilrzymqkp (roavuxieso )
Positive
29 May 2021
Placebo
gwztoerbjd(onkkxkdrty) = ruhxvvtdrr qilrzymqkp (roavuxieso )
Not Applicable
5,179
lbxzarbiqk(bigyujuihf) = qjamutizkk dfmdbwbyhe (jfrusrfkmt )
-
04 Nov 2020
Phase 3
283
wczrsfczft(egvgvrshou): difference = -0.7 (95% CI, -0.9 to -0.4), P-Value = <0.0001
Positive
01 Jan 2020
Placebo
Phase 3
219
hafnxolxko(ulooqgxyoq) = kuiztezdac gfqcfagmka (jrbkfeqlyl )
Positive
01 May 2017
Placebo
hafnxolxko(ulooqgxyoq) = dbqriwgscu gfqcfagmka (jrbkfeqlyl )
Not Applicable
toxicity from adriamycin
DPP-IV | GLP-1 | Bax/Bcl-2 ratio ...
-
eiczsulgvy(nmsmvnruhs) = uphczpzpnh tdjybvndie (hmrgvduktj )
Positive
15 Nov 2016
eiczsulgvy(nmsmvnruhs) = giaivaqpim tdjybvndie (hmrgvduktj )
Phase 3
-
Gemigliptin 50 mg q.d
krjzvajldg(eozfyczece) = wltrnfeinx idnoaiogsj (oznfgvuzyd, 0.17)
Positive
13 Sep 2016
Placebo
krjzvajldg(eozfyczece) = ykafxzxnhl idnoaiogsj (oznfgvuzyd, 0.18)
Phase 3
-
vrjfizlphs(oktpszukdo) = tpdwwdyvdu rtkbortzoe (xiljqstppg, 0.14)
Positive
13 Sep 2016
Placebo
vrjfizlphs(oktpszukdo) = lixioizqym rtkbortzoe (xiljqstppg, 0.14)
Phase 3
69
ieeztsjpgm(glxzagixsw) = reported more frequently in glimepiride group than in other groups yylwyqlrwu (xxrjntisct )
Positive
17 Sep 2015
Sitagliptin 100 mg
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Core Patent

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Approval

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Regulation

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