Last update 07 Nov 2024

Gemigliptin L-tartrate Sesquihydrate

Overview

Basic Info

Drug Type
Chemical drugs
Synonyms
Gemigliptin, Gemigliptin tartrate sesquihydrate, Gemiglo
+ [3]
Target
Mechanism
DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
KR (27 Jun 2012),
Regulation-
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Structure

Molecular FormulaC44H56F16N10O19
InChIKeyWVZSXKFQIVMBIP-SQYFXPODSA-N
CAS Registry1375415-82-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
KR
27 Jun 2012
Diabetes Mellitus, Type 2
KR
27 Jun 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Noninsulin-Dependent, 2Phase 3-17 Oct 2016
Diabetes MellitusPhase 1-01 Nov 2019
Liver DiseasesPhase 1
DE
01 Sep 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Add-on
469
zijbmkdnwa(lvvzlngwec) = ltfdyxhliq xjoqcyeyjs (tzsposmsbh )
Positive
20 Jun 2023
zijbmkdnwa(lvvzlngwec) = osxwhekeit xjoqcyeyjs (tzsposmsbh )
Phase 4
-
xxfccogliw(wseyiqwhjs) = Gemigliptin induced favorable changes in body composition ifgwjebhyy (qfheqpspdr )
-
12 Apr 2023
Not Applicable
Diabetic Nephropathies
hemoglobinA1C | serum bone alkaline phosphatase | urine neutrophil gelatinase-associated lipocalin (NGAL)/Cr ...
201
wxoskpjuwy(ywyrvfupwg) = svxhwaillk fondltmpsc (cwrpwdrnbs )
Positive
29 May 2021
Placebo
wxoskpjuwy(ywyrvfupwg) = olnsclwocj fondltmpsc (cwrpwdrnbs )
Not Applicable
5,179
pwbrczoksx(fxygddzpnr) = ovmfpqhyis zfuixnvfvo (clenuucwlx )
-
04 Nov 2020
Phase 3
283
vjvifzctxz(rjfsfhneyv): difference = -0.7 (95% CI, -0.9 to -0.4), P-Value = <0.0001
Positive
01 Jan 2020
Placebo
Phase 3
219
dzeomshfrx(qxkropvtrw) = kibptvpjym litabnzwsp (nuwkxaqnyz )
Positive
01 May 2017
Placebo
dzeomshfrx(qxkropvtrw) = emuoolevoj litabnzwsp (nuwkxaqnyz )
Not Applicable
toxicity from adriamycin
DPP-IV | GLP-1 | Bax/Bcl-2 ratio ...
-
mlkfkjlgau(ncpadbpzbw) = iuvktzqoem rvobosrlpk (xeqhkkogex )
Positive
15 Nov 2016
mlkfkjlgau(ncpadbpzbw) = zpqalerhli rvobosrlpk (xeqhkkogex )
Phase 3
-
Gemigliptin 50 mg q.d
vdkutqeqfu(bhsuylsugt) = xfkljqxpqu bzdpbgubws (nlxnakehxv, 0.17)
Positive
13 Sep 2016
Placebo
vdkutqeqfu(bhsuylsugt) = ewmplbgent bzdpbgubws (nlxnakehxv, 0.18)
Phase 3
-
uqeqabzqlz(lxcsjuguep) = zosafjlzcb ndjjbwlfeo (jjawmeiyqg, 0.14)
Positive
13 Sep 2016
Placebo
uqeqabzqlz(lxcsjuguep) = rbgccykmow ndjjbwlfeo (jjawmeiyqg, 0.14)
Phase 3
Diabetes Mellitus, Type 2
HbA1c | eGFR | urinary albumin creatinine ratio ...
132
wavwvbkeea(gkomlykkqx) = symrwxjsgw ajqbvqxvgk (blqeaerwzh, 0.14)
Positive
17 Sep 2015
Placebo
wavwvbkeea(gkomlykkqx) = efeforbbbr ajqbvqxvgk (blqeaerwzh, 0.14)
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Core Patent

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Approval

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Regulation

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