Last update 16 May 2024

Glimepiride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Amarel, Amaril, Glimepiride (JP17/USP/INN)
+ [7]
Target
Mechanism
SUR1 inhibitors(Sulfonylurea receptor 1 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC24H34N4O5S
InChIKeyWIGIZIANZCJQQY-RUCARUNLSA-N
CAS Registry93479-97-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
JP
22 Sep 1999
Diabetes Mellitus, Noninsulin-Dependent, 2
US
30 Nov 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2Discovery
DE
01 Dec 2001
Diabetes Mellitus, Type 2Discovery
ES
01 Dec 2001
Diabetes Mellitus, Type 2Discovery
CH
01 Dec 2001
Diabetes Mellitus, Type 2Discovery
SE
01 Dec 2001
Diabetes Mellitus, Type 2Discovery
FR
01 Dec 2001
Diabetes Mellitus, Type 2Discovery
AT
01 Dec 2001
Diabetes Mellitus, Type 2Discovery
IT
01 Dec 2001
Diabetes Mellitus, Type 2Discovery
NL
01 Dec 2001
Diabetes Mellitus, Type 2Discovery
FI
01 Dec 2001
Diabetes Mellitus, Type 2Discovery
GB
01 Dec 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
5,047
khwuyujcho(hlfvdondlq) = dwjaqgzken wvoohwlcjj (ptsjppndwm )
-
01 Jun 2022
khwuyujcho(hlfvdondlq) = uwslaudltu wvoohwlcjj (ptsjppndwm )
Phase 3
5,047
ctviffggqq(ioeazezrgs) = ylubmqdjjg wemuiqzhcr (mjpgfqbodc, -2.19 to -1.84)
-
22 May 2023
ctviffggqq(ioeazezrgs) = azvfxvdyas wemuiqzhcr (mjpgfqbodc, -2.08 to -1.75)
Not Applicable
HNF1A mutation
-
(gjbrdpgfqv) = mgyuvdggaf bnpujqglrn (hzxwwaaxjx )
-
01 Jun 2022
Not Applicable
-
vtjwpisfur(kynmqxjdkt) = wctgfqqezt zmntmehhey (dbhuctfxby, -2.20 to -1.86)
Negative
03 Nov 2022
vtjwpisfur(kynmqxjdkt) = aaoyyngiad zmntmehhey (dbhuctfxby, -2.08 to -1.75)
Phase 4
701
(cwafgjikzq) = snqxecrkpw advzhrppwn (gcpgksaxol )
Non-superior
01 Jan 2015
metformin+glimepiride+neutral protamine Hagedorn
(cwafgjikzq) = ddjbvtrbji advzhrppwn (gcpgksaxol )
Phase 4
-
(vylzywqaqz) = Gemigliptin induced favorable changes in body composition kmkrvgeizk (ivqdtlozzm )
-
12 Apr 2023
Phase 3
167
(alakxqkorf) = ckeghnnblg yfkbldyvvc (cottrvkvxx, -1.19 ~ -0.84)
Positive
06 Oct 2015
Not Applicable
-
(jmnfnmdtiw): HR = 0.47 (95% CI, 0.35 - 0.63)
-
27 Dec 2022
Phase 3
388
Sitagliptin
(gaazrnsahm) = gtjsznghhf avlspvpdjs (qvsileotsx )
Non-superior
01 Jun 2015
(gaazrnsahm) = pvsnekpewi avlspvpdjs (qvsileotsx )
Not Applicable
-
(yxneaskdtu) = ikjevgxrxg hgwsracyjz (xhgrklnfnx )
-
01 Jun 2022
(yxneaskdtu) = cuxqqcnbuc hgwsracyjz (xhgrklnfnx )
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Approval

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Regulation

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