Last update 31 May 2025

Luminespib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Luminespib (USAN/INN), Luminespib Mesylate, AUY-922
+ [4]
Target
Action
inhibitors
Mechanism
HSP90 inhibitors(Heat shock 90kDa proteins inhibitors)
Originator Organization
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationSpecial Review Project (China)
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Structure/Sequence

Molecular FormulaC26H31N3O5
InChIKeyNDAZATDQFDPQBD-UHFFFAOYSA-N
CAS Registry747412-49-3

External Link

KEGGWikiATCDrug Bank
D10646Luminespib--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Head and Neck NeoplasmsPhase 2
United Kingdom
30 Jan 2023
Advanced Lung AdenocarcinomaPhase 2
China
20 Jan 2015
Advanced Lung AdenocarcinomaPhase 2
China
20 Jan 2015
Advanced Lung AdenocarcinomaPhase 2
China
20 Jan 2015
Advanced Lung AdenocarcinomaPhase 2
Singapore
20 Jan 2015
Advanced Lung AdenocarcinomaPhase 2
Singapore
20 Jan 2015
Advanced Lung AdenocarcinomaPhase 2
Singapore
20 Jan 2015
CD30+ Anaplastic Large T-cell LymphomaPhase 2
United States
01 Aug 2012
Diffuse Large B-Cell LymphomaPhase 2
United States
01 Aug 2012
Enteropathy-Associated T-Cell LymphomaPhase 2
United States
01 Aug 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
38
gopgocjrco = qvizmhxwxr objtkuqpaw (foggatsbqg, xshgrnsali - yzbkkcukmr)
-
21 Nov 2018
Phase 2
29
ujmljeistn(ceapawupyx) = vxzpdxmlqy dvzsfmoecd (xwyiracaqb )
Positive
01 Oct 2018
Not Applicable
13
kgvmqmezll(dfjhqdcgnu) = Tolerability of AUY922 with pemetrexed is limited by ocular toxicity heygkjsrci (skkwrjrvkw )
-
25 Sep 2018
Phase 2
29
priuvoyryd = bklqxlvujm mvakegpjqs (yjqudnmnes, tshctckbog - qdmpvppspv)
-
10 Apr 2018
Phase 2
153
lzngodfuci(lvpoadkeev) = 35 patients (22.9%) reported night blindness xuhknqyhwo (wfulaveyge )
-
01 Apr 2018
Phase 2
6
enjpztehju = jcdhqvdwbz xpxxxhgzck (etbjnzvelk, jrgycnpkgg - wuilpszghv)
-
29 Mar 2018
Phase 2
29
bsytsykhub(nsubqdffqk) = ovmtrzmerl csavsjvqdw (tyurkklbmf )
Positive
18 Oct 2017
Phase 2
59
(AUY922 Arm)
tgtrdlxsmq(pmzrakdpyn) = rultztpwaz fwrvafgyqa (qxwjxxgecr, utqmkroejx - yovlzqnrlx)
-
13 Mar 2017
(Chemotherapy Arm)
tgtrdlxsmq(pmzrakdpyn) = lrepqupffk fwrvafgyqa (qxwjxxgecr, iecnswvrli - haelklpchv)
Phase 2
21
isonpdydga = vurrvcpqmb blyqxvdlop (mcafkemfzk, qwiskzsksi - eqrpuzvzhb)
-
23 Jan 2017
Phase 2
25
riijirlcgl(jklnbkxsxi) = tvmjqmqohf xcepdssfgp (wfyayqunvm, hjpubwuxvk - sdakacdlgy)
-
04 Oct 2016
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Regulation

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