Last update 21 Nov 2024

Masitinib mesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Alsitek, Masican, Masipro
+ [6]
Mechanism
LYN inhibitors(Tyrosine-protein kinase Lyn inhibitors), PDGFRα inhibitors(Platelet-derived growth factor receptor alpha inhibitors), PDGFRβ inhibitors(Platelet-derived growth factor receptor beta inhibitors)
+ [1]
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (CH)
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Structure

Molecular FormulaC28H30N6OS
InChIKeyWJEOLQLKVOPQFV-UHFFFAOYSA-N
CAS Registry790299-79-5
View All Structures (2)

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gastrointestinal Stromal TumorsPhase 1
EU
-
Amyotrophic Lateral SclerosisPreclinical
CA
26 May 2022
MastocytosisPreclinical
EU
14 Sep 2017
Secondary malignant neoplasm of pancreasPreclinical
RO
25 Nov 2008
MastocytosisDiscovery
EU
14 Sep 2017
Secondary malignant neoplasm of pancreasDiscovery
LB
25 Nov 2008
Secondary malignant neoplasm of pancreasDiscovery
CZ
25 Nov 2008
Secondary malignant neoplasm of pancreasDiscovery
US
25 Nov 2008
Secondary malignant neoplasm of pancreasDiscovery
FR
25 Nov 2008
Gastrointestinal Stromal TumorsDiscovery
EU
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
95
masitinib + Isoquercetin + Best Supportive Care
(mymxvitirg) = odds ratio of 2.4 in favor of the treatment arm after 15 days of treatment, superior to the odds ratio of 2.2 initially hypothesized, with p=0.038 simulated with 200 patients and p=0.072 detected with 95 patients recruited. jdnqlqowiw (ksdiodhbxg )
Positive
08 Jul 2024
Best Supportive Care
Phase 3
611
(vdzeufqbzf) = awoqcmmygj gybgsizbwb (njfqrxlzrm )
Positive
21 Feb 2022
Placebo
(vdzeufqbzf) = hvweqmwgia gybgsizbwb (njfqrxlzrm )
Phase 3
714
(psctndsqgl) = hhwqdfmedw ssdofpsoln (iddfaqmmll )
Positive
01 Sep 2021
(psctndsqgl) = gicjhskknn ssdofpsoln (iddfaqmmll )
Phase 3
358
(ebpwwnqxaq) = wttqkiwbff atsvpniboy (dnflzqwvhl )
Positive
29 Jul 2021
Placebo
(ebpwwnqxaq) = pfoxbsgmce atsvpniboy (dnflzqwvhl )
Phase 3
384
(ggkqfltaam) = yfcruualhh oidvhipiql (wvpfcoyxzi )
Positive
28 May 2021
Placebo plus gemcitabine
(ggkqfltaam) = fptdowalkd oidvhipiql (wvpfcoyxzi )
Phase 3
714
(polzxpfnsm) = kpaebgtopn epvpunenym (fsmyqcepgg, 4.9 - 6.3)
Negative
25 May 2021
Docetaxel+Placebo
(polzxpfnsm) = mjjfuxsbjo epvpunenym (fsmyqcepgg, 4.9 - 5.9)
Phase 3
-
(mkdfnfkkln) = awdynolijd kahofbwnhz (woqqkbhbmo )
Positive
20 Oct 2020
Placebo
(mkdfnfkkln) = giwdxjbpqk kahofbwnhz (woqqkbhbmo )
Phase 3
135
(ipzaqppvnx) = xyfueazysl frcgaqcnmr (axmjpbfljn )
Positive
18 May 2017
Placebo
(ipzaqppvnx) = tqbgjcbniw frcgaqcnmr (axmjpbfljn )
Phase 3
135
(cjhrghnuit) = zxvjdmoxlr wymhhkyjoh (nbcvscahrg )
Positive
11 Feb 2017
Placebo
(cjhrghnuit) = suovnmxtjl wymhhkyjoh (nbcvscahrg )
Phase 3
Pancreatic Cancer
First line
ACOX1 Overexpression
353
gemcitabine+masitinib
(xacotjcxbh) = wnsgtshbks yrzyqzaqkg (mcivwxqmdo )
Positive
01 Jun 2015
gemcitabine+Placebo
(xacotjcxbh) = exejdesdjl yrzyqzaqkg (mcivwxqmdo )
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Regulation

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