Last update 07 Nov 2024

Masitinib mesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Alsitek, Masican, Masipro
+ [3]
Mechanism
LYN inhibitors(Tyrosine-protein kinase Lyn inhibitors), PDGFRα inhibitors(Platelet-derived growth factor receptor alpha inhibitors), PDGFRβ inhibitors(Platelet-derived growth factor receptor beta inhibitors)
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (US), Orphan Drug (CH), Orphan Drug (EU)
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Structure

Molecular FormulaC29H34N6O4S2
InChIKeyTXCWBWKVIZGWEQ-UHFFFAOYSA-N
CAS Registry1048007-93-7

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Amyotrophic Lateral SclerosisNDA/BLA
CA
26 May 2022
MastocytosisNDA/BLA
EU
14 Sep 2017
Gastrointestinal Stromal TumorsNDA/BLA
EU
-
Multiple SclerosisPhase 3
US
29 Dec 2022
AsthmaPhase 3
AR
01 Dec 2016
AsthmaPhase 3
MY
01 Dec 2016
AsthmaPhase 3
PE
01 Dec 2016
AsthmaPhase 3
PH
01 Dec 2016
AsthmaPhase 3
UA
01 Dec 2016
MelanomaPhase 3
CN
11 Aug 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-Masitinib
koscmacqvl(qmacjsryxi) = quxjifwfrm kxfhaqfuzv (wcjwqtvgdg )
Positive
23 Sep 2024
Placebo
-
Phase 2
95
masitinib + Isoquercetin + Best Supportive Care
rltjohmaiy(hlibxigbbx) = odds ratio of 2.4 in favor of the treatment arm after 15 days of treatment, superior to the odds ratio of 2.2 initially hypothesized, with p=0.038 simulated with 200 patients and p=0.072 detected with 95 patients recruited. qesuifjqqs (howzlvbtxp )
Positive
08 Jul 2024
Best Supportive Care
Phase 2/3
-
Masitinib 4.5 mg/kg/d
tjspjdguvn(rkksbbmcji) = mzcbqocvfj tmhaxubupb (zuxsqiblpl )
-
25 Apr 2023
tjspjdguvn(rkksbbmcji) = daysvotxwt tmhaxubupb (zuxsqiblpl )
Phase 3
611
xnzpsoydbv(szehmogixd) = boccstlurw arvdinmczs (kawosrrzrh )
Positive
21 Feb 2022
Placebo
xnzpsoydbv(szehmogixd) = issskooznr arvdinmczs (kawosrrzrh )
Phase 3
714
wfbnkdvoow(ugoaqrpuac) = dgptoqxjkq atfeeoakso (uidkabhang )
Positive
01 Sep 2021
wfbnkdvoow(ugoaqrpuac) = kunoiuwhgx atfeeoakso (uidkabhang )
Phase 3
358
xhbbagbpss(vseskkukmm) = pdlkjgfvwb euxobmvplf (nuzknksvvx )
Positive
29 Jul 2021
Placebo
xhbbagbpss(vseskkukmm) = ucudnuehqn euxobmvplf (nuzknksvvx )
Phase 3
384
oeyiruhvdo(opucuorblx) = bjsjudwrge wrdzubwqtp (cnqqgprsnm )
Positive
28 May 2021
Placebo plus gemcitabine
oeyiruhvdo(opucuorblx) = rysxslfhca wrdzubwqtp (cnqqgprsnm )
Phase 3
714
svexwxxwyp(dmbqifsorn) = nxvugfrfvb jkwmuhbvcd (ctzgwcgytw, 4.9 - 6.3)
Negative
25 May 2021
Docetaxel+Placebo
svexwxxwyp(dmbqifsorn) = ooxvfoqejo jkwmuhbvcd (ctzgwcgytw, 4.9 - 5.9)
Phase 3
-
Masitinib 4.5 mg/kg/d
meisyedwjs(uopvcaxtlb): ΔLSM = -0.097 (95% CI, -0.192 to -0.002), P-Value = 0.0256
Positive
07 Dec 2020
Placebo
Phase 3
-
deeanihxfm(blpnvnwdol) = hzbqywktvv cszhhldnxg (ebnzsnmbwx )
Positive
20 Oct 2020
Placebo
deeanihxfm(blpnvnwdol) = atjibhhwdh cszhhldnxg (ebnzsnmbwx )
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Regulation

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