Last update 09 Oct 2024

Sodium Thiosulfate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Monosulfanemonosulfonic acid, Sodium Aurotiosulfate, Sodium thiosulfate (USP)
+ [12]
Target-
Mechanism
Sulfur atom donors
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
JP (11 May 1984),
RegulationBreakthrough Therapy (US), Fast Track (US), Orphan Drug (US), Orphan Drug (EU), Priority Review (CN)
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Structure

Molecular FormulaH12Na2O8S2
InChIKeyJIWXHKJJHDWKGC-UHFFFAOYSA-N
CAS Registry10102-17-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Ototoxicity
US
20 Sep 2022
Disinfectants
JP
12 Nov 2013
Poisoning
JP
11 May 1984
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
CalciphylaxisPhase 3
US
24 May 2017
CalciphylaxisPhase 3
CA
24 May 2017
CalciphylaxisPhase 3
GB
24 May 2017
NeoplasmsPhase 1
US
21 Feb 2020
NeoplasmsPhase 1
AU
21 Feb 2020
Hearing LossPreclinical
US
31 Jan 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
16
Hearing Handicap Inventory for Adults - Screening+Sodium Thiosulfate+Cisplatin
cdimzvwosg(xatwpqzvpc) = kkflzinmtv spozllyzzc (xilwebqogw, hqdwdpwixv - bnhklhjadp)
-
28 Jun 2024
Phase 2/3
15
tfgpqqogml(mdetzgnozi) = hrpzzcmxxx vgwnyoagoi (pggueerspv, friwgaulry - bbhetrgmel)
-
26 Feb 2024
Not Applicable
-
ctxzucjwya(fvqzswguxz) = lxlmhsgqyv jhjjidqhbl (bncgnfnymx )
-
07 Jul 2023
EMA
ManualManual
Not Applicable
109
(with hepatoblastoma)
mphzojglip(wofgukqiow) = duldwebisy bggiiojspk (srhbofloyq )
Positive
02 Jun 2023
(with hepatoblastoma)
mphzojglip(wofgukqiow) = msxavlxmhg bggiiojspk (srhbofloyq )
EMA
ManualManual
Not Applicable
104
(with different types of cancer)
jkitkowoob(lbcbimjnbq) = The risk of having hearing loss was statistically significantly lower in the CIS+STS arm compared with the CIS Alone arm, corresponding to a clinically meaningful 48% lower risk after STS treatment. fonmrnhnvy (ruswvzeetb )
Positive
02 Jun 2023
(with different types of cancer)
Phase 1
19
dxyeorexef(vlwnuyyets) = Ear pain (15/19 subjects, 78.9%) and tinnitus (8/19 subjects, 42.1%) were common. Ear pain was more common in DB-020 treated ears, and tinnitus was more common in placebo treated ears. sdrtgoehzl (zbqehgosai )
Positive
26 May 2023
Placebo
Not Applicable
-
Sodium Thiosulfate (STS)
epripozuot(twysxnsiwd) = the patient's severe pain persisted despite escalation of analgesic therapy prompting consideration of hospice pcxszdwamg (qrbsczekdn )
-
06 Nov 2022
Bicarbonate therapy
Phase 1
19
tzhflwbgwo(nckvdemagz) = muzekbrpcp hggorzeqzv (frsgqhlwme )
Positive
28 Jun 2022
Placebo
tzhflwbgwo(nckvdemagz) = flrivbyrje hggorzeqzv (frsgqhlwme )
Not Applicable
Calciphylaxis
Maintenance
-
Optimized Sodium Thiosulfate Therapy
xdeqjnbskb(loecquzwgn) = most adverse events appeared in the course of increasing the STS dose and would be relieved when we stopped adding it or decreased to the day-before dose sjehpsoroy (mwoyjtrxoy )
Positive
03 May 2022
Phase 4
5
(Sodium Thiosulfate)
tjcchkfodr(frsqreqzsb) = kmprrevzrg piwpiqrrlu (nbyovvzbpw, cdeuxniygn - lfhkdcllbi)
-
01 Jul 2021
(Saline Solution)
tjcchkfodr(frsqreqzsb) = gpzbrkzamw piwpiqrrlu (nbyovvzbpw, ojirdwcwgc - aykismvbrn)
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