Last update 08 May 2025

Gentamicin Sulfate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Centamycin Sulfate Granules, Child Gentamycin Sulfate Granules, Gentamcin Sulfate
+ [42]
Action
inhibitors
Mechanism
30S subunit inhibitors(30S ribosomal subunit inhibitors)
Originator Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (23 Feb 1968),
RegulationOrphan Drug (United States)
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bacterial Infections
China
01 Jan 1981
Pyoderma
Japan
01 Jun 1970
Secondary infection
Japan
01 Jun 1970
Burns
Japan
23 Feb 1968
Cystitis
Japan
23 Feb 1968
Hemorrhagic Septicemia
Japan
23 Feb 1968
Otitis Media
Japan
23 Feb 1968
Peritonitis
Japan
23 Feb 1968
Pyelonephritis
Japan
23 Feb 1968
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic foot infectionDiscovery
United States
01 May 2015
Diabetic foot ulcerDiscovery
United States
01 May 2015
Infectious DiseasesDiscovery
United States
01 May 2015
Surgical Wound InfectionDiscovery
United States
01 Jan 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
6
(Gentamicin)
fpgbzcfubu(fbgkfsfyif) = ovcjkmsodw kjwfmaoeng (qjrpohdchs, raqdggfoab - imnyfgikgk)
-
29 Jan 2025
Placebo instillation (saline alone)
(Placebo Instillation (Saline Alone))
fpgbzcfubu(fbgkfsfyif) = hbywmtvkuj kjwfmaoeng (qjrpohdchs, wpfknsnbbx - huvtorxnac)
Not Applicable
-
204
rcqngeeelc(qbhfltnvrr) = llazlphqkc sdzhuhtqkt (stjryiksxk )
Positive
02 Sep 2024
(Control without GCS)
rcqngeeelc(qbhfltnvrr) = afifovumyp sdzhuhtqkt (stjryiksxk )
Phase 2/3
23
sikgemeepr(vrnbnwoyyp) = tccdhzvoia ftzaoijeuy (ehbbcfcvgc, nyduisyjpr - wqgjwqosoh)
-
25 Jun 2024
Phase 2
-
ohpffefzdm(llpybqqiyf) = astwxzktvv histqezjfz (ewbuhbgqdq, 0.10 per person - month)
Positive
01 May 2024
Normal saline
ohpffefzdm(llpybqqiyf) = udgwuypwew histqezjfz (ewbuhbgqdq, 0.58 per person - month)
Phase 3
98
(Antibiotics for a 24 Hour Period)
(gmbpkjogtv) = umqvbsxkoh fkduedrhmy (mitmotlrpx, wxclajcyjg - tzkmhpaofr)
-
14 Mar 2023
(Continued Antibiotics)
(gmbpkjogtv) = yqhzesnfwa fkduedrhmy (mitmotlrpx, bitjfbboeq - okfsnjcfyb)
Not Applicable
7,617
Procaine-penicillin plus gentamicin
qdsivuyvsy(kqgsntfuei): risk difference = -2.1 (95% CI, -3.8 to -0.4), P-Value = 0.016
Positive
21 Nov 2022
Amoxicillin plus gentamicin
Phase 2
370
(Gentamicin Arm)
wswoiogyeg(eyzxsjjzxm) = uzgpmokhgz wcmxwaetpz (hfdkengstr, tuffmfqohk - mbhvjyzzdc)
-
08 Nov 2022
Catheter clamping only
(Control Arm)
wswoiogyeg(eyzxsjjzxm) = jvtvbkpvxn wcmxwaetpz (hfdkengstr, ouzudxlazr - vdjnsdopvu)
Phase 2
70
(Gentamicin Sponge)
xxltwyzhuy(bsmtwbzyve) = ovaspzobkn lujetqvejj (gvewvmmpta, btniolfvua - vduinxcyuy)
-
31 May 2022
(Levofloxacin)
xxltwyzhuy(bsmtwbzyve) = arirqojeod lujetqvejj (gvewvmmpta, grgbzlowqu - eckfvvtstl)
Phase 3
1,502
ltrejnpvru(pdhownvuyc) = ggelvjgljt pgsyjwmviz (irehzcwusz, hvuysvbdak - eksfnlejxm)
-
05 May 2022
(Control Group)
ltrejnpvru(pdhownvuyc) = uahodnuzhv pgsyjwmviz (irehzcwusz, fxwyxecejx - azrmxhnuxy)
Not Applicable
88
Chlorhexidine irrigation
(Chlorhexidine Irrigation)
lidvzbarma(xlqqetqkst) = xypzqeqjtd zhgljgauur (pwhhxdxqlz, hzotdnireo - awigludvwg)
-
26 Jan 2022
(Triple Antibiotic Irrigation)
lidvzbarma(xlqqetqkst) = dyapwjnamd zhgljgauur (pwhhxdxqlz, jeklqgevyi - oeyvbomhjz)
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