Women with a history of gestational diabetes mellitus (GDM) are at a 2-fold greater risk for the development of overt cardiovascular disease (CVD) following the effected pregnancy. While subsequent development of type II diabetes elevates this risk, prior GDM is an independent risk factor for CVD morbidity, particularly, within the first decade postpartum. GDM is associated with impaired endothelial function during pregnancy and decrements in macro- and microvascular function persist postpartum, despite the remission of insulin resistance following delivery. Collectively, while the association between GDM and elevated lifetime CVD risk is clear, and available evidence demonstrates a link between GDM and vascular dysfunction in the decade following pregnancy, the mechanisms mediating this persistent dysfunction remain unexamined.
The purpose of this investigation is to examine the role of endothelin-1, a potent vasoconstrictor, in aberrant microvascular function in otherwise healthy women with a history of GDM and to identify whether this mechanism is influenced by physical activity and sedentary behavior.

Start Date01 Sep 2024

Sponsor / Collaborator

University of Iowa

NCT06532461 / RecruitingNot ApplicableIIT

A Randomized Controlled Trial Testing the Influence of Three- and Seven-days Insulin Infusions and Two Types of Insulin on Hyperechogenicity in Subcutis and Glycemic Variables in Children and Adolescents With Type 1 Diabetes

More and more children and adolescents are using diabetes devices attached to the skin. The attachment of infusions sets to the skin provoke allergenic or toxic eczema, the continous infusion of insulin provoke subcutaneous changes and prolonged wear time seems to increase the risk of these complication. On the other site fewer skin stripping episodes with longer wear time and filtration of the insulin may be beneficial for the skin, therefore comparing the occurrence of subcutaneous hyper echogenicity, eczema and the skin barrier in users of 3 and 7 days infusions set is highly relevant. The primary aim of present study is to investigate if the use of three days insulin infusion set is superior to seven days in preventing the occurrence of hyperechogenicity in areas recently used for insulin infusion and if the type of insulin matter comparing insulin aspart - Novo Rapid, or insulin lispro - Humalog

Start Date20 Jul 2024

Sponsor / Collaborator

Steno Diabetes Center A/S

NCT06558708 / RecruitingPhase 2

A Phase II Trial Comparing Efficacy, Tolerability, and Safety of GZR101 Injection and GZR33-70 Injection in Type 2 Diabetes Inadequately Controlled on Basal Insulin or Premixed Insulin Once Daily at Least With or Without Pre-dinner Meal-time Insulin

This trial is conducted in China. The aim of the trial is to compare the efficacy, tolerability, and safety of GZR101 Injection and GZR33-70 Injection in type 2 diabetes inadequately controlled on basal/ premixed insulin once daily at least with or without pre-dinner meal-time insulin.

Start Date28 Jun 2024

Sponsor / Collaborator

Gan & Lee Pharmaceuticals Co., Ltd.

100 Clinical Results associated with Insulin aspart

100 Translational Medicine associated with Insulin aspart

100 Patents (Medical) associated with Insulin aspart

1,383

Literatures (Medical) associated with Insulin aspart

01 Dec 2024·Diabetes Therapy

Switching from Premixed Insulin to Insulin Degludec/Insulin Aspart for the Management of Type 2 Diabetes Mellitus: Implications of a Real-World Study on Insulin Degludec Dosing

Article

Author: Li, Ang ; Zhang, Junqing ; Wu, Yiming

INTRODUCTIONWhen switching from premixed insulin to insulin degludec/aspart (IDegAsp), IDegAsp usually starts at the same dose as the premixed insulin according to limited clinical experience or at a dose according to clinician discretion. The dose of insulin degludec used in the real world after switching has been poorly investigated.METHODSA retrospective analysis was conducted on patients with type 2 diabetes who switched from premixed insulin to IDegAsp from October 2016 to December 2023. Repeated measures analysis of variance was used to compare changes in insulin dose, glycated hemoglobin (HbA1c), fasting blood glucose (FBG), and postprandial blood glucose (PBG) before and after switching.RESULTSSixty-six patients with prior low-ratio premixed insulin and 22 with prior mid-ratio premixed insulin were included. Among the low-ratio insulin users, the total daily dose of insulin degludec (IDeg) decreased by 21.43% and 19.05% at 3 and 6 months, respectively, after switching, compared with prior basal insulin dose (both p < 0.001). Conversely, among mid-ratio insulin users, the IDeg daily dose increased by 10.71% and 32.14% at 3 and 6 months, respectively, after switching, compared with prior basal insulin dose (both p < 0.001). In all patients, HbA1c levels decreased by 0.70%, FBG decreased by 1.00 mmol/l, and PBG decreased by 1.61 mmol/l after 6 months of switching (all p < 0.05); the total daily insulin dose and injection frequency significantly decreased after switching (both p < 0.05); age and disease duration did not affect IDegAsp effects on HbA1c reduction.CONCLUSIONSIn the setting of transition to IDegAsp from premixed insulin, the dose of basal insulin in the premixed formulation can be a valuable reference for adjusting insulin degludec dose. IDegAsp is superior to premixed insulin in blood glucose control with reduced total daily dose and injection frequency. IDegAsp could be the best choice for the management of diabetes in elderly patients.

08 Nov 2024·Medicine

Survey of fear and compliance of Insulin Degludec and Insulin Aspart injection in type 2 diabetes mellitus patients and analysis of influencing factors

Article

Author: He, Qiqiang ; Xie, Min ; Chen, Sisi

This study aims to investigate the fear and compliance of Insulin Degludec and Insulin Aspart (IDegAsp) injection in type 2 diabetes mellitus (T2DM) patients and study the factors influencing patient compliance. A total of 120 patients with T2DM treated from February 2019 to March 2022 were investigated and analyzed for fear and compliance on the Diabetes Fear of Injecting and Self-testing Questionnaire of diabetic patients and were divided into compliance and noncompliance groups according to the results to analyze the factors affecting patient compliance. The study found a high level of fear of IDegAsp injection among the 120 T2DM patients, with an average Diabetes Fear of Injecting and Self-testing Questionnaire score of (39.19 ± 4.59) points. Scores for medication compliance, dietary compliance, blood sugar monitoring, and lifestyle changes were (10.48 ± 1.52) points, (12.18 ± 2.27) points, (0.84 ± 0.12) points, and (9.13 ± 2.21) points, respectively. There was no significant difference between the compliance and noncompliance groups in terms of gender, age, lifestyle, educational level, occupation, current treatment method, family monthly income per capita, and medical payment method (P > .05). However, there were significant differences influenced by disease duration, complications, cognitive level, self-efficacy level, comorbidity count, and living status (P < .05). Multifactorial analysis showed that educational level, disease duration, complications, cognitive level, self-efficacy level, comorbidity count, and living status all affected patient compliance (P < .05). Educational level, disease duration, complications, cognitive level, self-efficacy level, comorbidity count, and living status are important factors affecting the fear and treatment compliance of IDegAsp injection in T2DM patients. These findings have implications for improving patient compliance and alleviating treatment fear.

01 Nov 2024·Diabetes, Obesity and Metabolism

The efficacy and safety of insulin glargine 100 U/mL + lixisenatide versus insulin degludec + insulin aspart in Chinese people with type 2 diabetes suboptimally controlled with oral antidiabetic drugs: The Soli‐D randomized controlled trial

Letter

Author: Mu, Yiming

In the Soli-D study, the strongest effect on average PPG from seven-point SMPG with insulin glargine 100 U/mL + lixisenatide (iGlarLixi) was observed with the meal following the injection, which was the first meal of the day.However, the effect of iGlarLixi on PPG after all meals was clin. relevant and within the Chinese Diabetes Society guidelines recommended target PPG value of ≤10.0 mmol/L.In conclusion, both iGlarLixi and IDegAsp effectively addressed PPG in Chinese people with type 2 diabetes, previously suboptimally controlled with OAD(s), with iGlarLixi achieving a greater mean reduction in PPG at breakfast, lunch and for the mean of all meals.

News (Medical) associated with Insulin aspart

15 Oct 2024

·pipelinereview.com

Gan & Lee Pharmaceuticals' Three Innovative Drugs: GZR18 Injection, GZR4 Injection, and GZR101 Injection Achieve Primary Endpoints in Phase 2 Clinical Studies

BEIJING, China I October 15, 2024 I Recently, Gan & Lee Pharmaceuticals (Gan & Lee, Shanghai Stock Exchange: 603087) announced that three of its independently developed drugs — the bi-weekly GLP-1 receptor agonist GZR18 injection, the once-weekly basal insulin analog GZR4 injection, and the premixed dual insulin analog GZR101 injection — successfully achieved positive results in three Phase 2 clinical trials conducted in adult patients with Type 2 diabetes (T2D) in China. In these studies, Gan & Lee’s three innovative drugs demonstrated superior or comparable efficacy in lowering glycated hemoglobin (HbA1c) compared to the respective positive comparator drugs separately. Gan & Lee Pharmaceuticals’ Diabetes Product Portfolio Diagram Statement: 1. GZR18, GZR4, and GZR101 are investigational drugs that have not yet been approved in China. 2. Gan & Lee Pharmaceuticals does not recommend the use of any unapproved drugs/indications. GZR18 Injection: a Phase 2 Study evaluate the Efficacy and Safety of GZR18 Injective vs. Semaglutide (Ozempic ® ) in Chinese Patients with Type 2 Diabetes The Phase 2b clinical trial (CTR20232069) is a multicenter, randomized, open-label study comparing the efficacy and safety of GZR18 injection versus semaglutide (Ozempic ® ) in Chinese adult T2D patients with poor glycemic control on lifestyle interventions and/or unregulated use of anti-diabetic drugs, and on oral anti-diabetic treatment for at least three months. A total of 264 subjects were recruited across 25 clinical centers in China. Patients were randomized to receive bi-weekly GZR18 injections (12 mg, 18 mg, or 24 mg) or once-weekly 24 mg GZR18 injections, or 1 mg semaglutide for 24 weeks, including the dose-escalation period. The primary efficacy endpoint was the change in HbA1c from baseline after 24 weeks of continuous treatment. The subjects had a mean diabetes history of 11-18 years, and baseline HbA1c ranged from 8.28% to 8.56%. After 24 weeks of treatment, the mean HbA1c reduction from baseline in the GZR18 groups was as follows: 1.87% (12 mg, bi-weekly), 2.28% (18 mg, bi-weekly), 1.94% (24 mg, bi-weekly), and 2.32% (24 mg, once-weekly), all higher than the semaglutide group (1.60% reduction)*. Additionally, in treatment-naïve patients with poor glycemic control on lifestyle interventions, the HbA1c reduction in the bi-weekly GZR18 injection group reached 2.98%, compared to 2.04% in the semaglutide group, with a significant HbA1c reduction (p < 0.05)*. After 24 weeks of treatment, patients in the bi-weekly GZR18 group experienced a maximum weight loss of 5.42 kg, compared to 3.25 kg in the semaglutide group*. GZR18 also greatly improved fasting glucose, blood pressure, and lipid levels, etc, providing comprehensive benefits for diabetic patients. GZR18 was generally well-tolerated, with safety and tolerability consistent with known GLP-1 receptor agonists. The most common adverse events were gastrointestinal-related, and no severe hypoglycemic events were observed. GZR4 Injection: a Phase 2 Study Comparing the Efficacy and Safety of GZR4 injection vs. insulin degludec (Tresiba ® ) in Chinese Patients with Type 2 Diabetes The Phase 2 trial (CTR20232431) was a multicenter, randomized, open-label, parallel-group study evaluating the efficacy, tolerability and safety of once-weekly GZR4 injections versus once-daily insulin degludec (Tresiba ® ) in 83 T2D patients with poor glycemic control on oral antidiabetic drugs (Part A) and 96 T2D patients with poor glycemic control on a combination of oral antidiabetic drugs and basal insulins (Part B). In part A, the mean HbA1c reduction of once-weekly GZR4 injection was 1.50%, comparable to insulin degludec’s reduction of 1.48%. In part B, GZR4 injection demonstrated a superior HbA1c reduction of 1.26%, compared to -0.87% for insulin degludec (treatment difference: -0.38%, p < 0.01)*. In addition, improvements in time-in-range (TIR) were comparable between GZR4 and insulin degludec. In this study, GZR4 injection showed good safety and tolerability, with no severe hypoglycemic events observed. GZR101 Injection: a Phase 2 Study Comparing the Efficacy and Safety of GZR101 injection vs. insulin degludec/insulin aspart (Ryzodeg ® ) in Chinese Patients with Type 2 Diabetes The Phase 2 clinical trial (CTR20232431) is a multicenter, randomized, open-label, parallel-controlled, treat-to-target Phase 2 study. Part A of the study aimed to compare the efficacy, safety, and tolerability of GZR101 injection administered once-daily versus insulin degludec/insulin aspart (Ryzodeg ® ) administered once-daily over 16 weeks in 62 patients with uncontrolled T2D on oral anti-diabetic drugs. In Part B, the study compared the efficacy, safety, and tolerability of GZR101 injection combined with insulin aspart versus insulin degludec/insulin aspart (Ryzodeg ® ) administered twice-daily over 16 weeks in 91 patients with uncontrolled T2D on basal/premixed insulin. In Part A, the HbA1c levels in the once-daily GZR101 injection group decreased by 1.56%, superior to the -1.31% reduction in the once-daily insulin degludec/insulin aspart group (treatment difference: -0.24%). In Part B, GZR101 injection combined with insulin aspart achieved HbA1c reductions of -1.64% (once-daily insulin aspart) and -1.68% (twice-daily insulin aspart), both higher than the -1.59% reduction in the twice-daily insulin degludec/insulin aspart group (treatment differences of -0.06% and -0.09%, respectively)*. Moreover, GZR101 injection demonstrated comparable efficacy to insulin degludec/insulin aspart in controlling fasting and postprandial blood glucose, as well as improving time-in-range (TIR). In this trial, GZR101 injection showed good safety and tolerability. The estimated incidence of hypoglycemic events in both groups did not show statistically significant differences during the study. *The trial results are presented as least squares means (LS mean). Note: severe hypoglycemia is defined as Grade 3 hypoglycemia (serious events without specific plasma glucose boundaries, with conscious and/or somatic changes, hypoglycemia requiring help from others). Dr. Zhong-ru Gan, Chairman of Gan & Lee Pharmaceuticals, stated: “The positive results achieved by GZR18, GZR4, and GZR101 in Phase 2 clinical trials mark an important milestone in improving the current landscape of diabetes treatment. These results demonstrate that our three products provide better glycemic control compared to similar antidiabetic drugs. Over the years, we have successfully launched a full range of insulin products, from human insulin to insulin analogs, covering both basal and mealtime insulin, in the hope of comprehensively meeting the treatment needs of different diabetes patients. With recent breakthroughs in our research and development, we have also expanded our product portfolio with oral antidiabetic drugs, filling a gap in this critical area. Focusing on the frontiers of the endocrine field, we are actively promoting the development of new drugs, aiming to achieve comprehensive management of chronic metabolic diseases, including diabetes and obesity. Gan & Lee’s product portfolio currently covers next-generation insulin based on the extension to emerging metabolic disease targets, such as GLP-1 receptor agonists, supporting patients throughout their treatment journey with a view to driving changes in the management of diabetes and metabolic diseases and improving the quality of life of patients.” Forward-Looking Statements: These forward-looking statements are based on expectations and assumptions as of the date of this release. Due to various factors, actual results may differ significantly. We do not undertake any obligation to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise. Reference 1. WANCAI XING, WEI CHEN, YINING ZHANG, JING GAO, ANSHUN HE, JUN ZHANG, YING DENG, FANGKAI XUE, YONGCHUN WANG, HAO FU, RUNYAO ZHANG, JINHUI HUANG, ZHONGRU GAN; 823-P: Molecular and Pharmacological Properties of GZR4, a Once-Weekly Insulin Analog. Diabetes 14 June 2024; 73 (Supplement_1): 823–P. https://doi.org/10.2337/db24-823-P About Gan & Lee Gan & Lee Pharmaceuticals developed the first Chinese domestic insulin analog. Currently, Gan & Lee has six core insulin products, including five insulin analog varieties: long-acting glargine injection (Basalin ® ), fast-acting lispro injection (Prandilin™), fast-acting aspart injection (Rapilin ® ), mixed protamine zinc lispro injection (25R) (Prandilin™25), aspart 30 injection (Rapilin ® 30), and one human insulin injection – mixed protamine human insulin injection (30R) (Similin ® 30). The company has two approved medical devices in China, namely reusable insulin injection pen (GanleePen), and disposable pen needle (GanleeFine ® ). In China’s 2024 National Insulin-Specific Centralized Procurement, Gan & Lee Pharmaceuticals ranked first among all selected companies in terms of procurement demand for insulin analogs. The company is also making strides in international markets, with the disposable pen needle (GanleeFine ® ) approved by the US Food and Drug Administration (FDA) in 2020 and received GMP inspection approval from the European Medicines Agency (EMA) in 2024. These achievements significantly boost Gan & Lee’s competitiveness in both international and domestic markets. In the future, Gan & Lee will strive for comprehensive coverage in diabetes treatment. Moving forward with its mission to become a world-class pharmaceutical company, Gan & Lee will also actively develop new chemical entities and biological drugs, focusing on treatments for metabolic diseases, cardiovascular diseases, and other therapeutic areas. Further Information: BPRD@ganlee.com (Media) BD@ganlee.com (Business Development) info.medical@ganlee.com (Medical Information) SOURCE: Gan & Lee Pharmaceuticals

Clinical ResultPhase 2Drug Approval

15 Oct 2024

·www.prnewswire.com

Gan & Lee Pharmaceuticals' Three Innovative Drugs: GZR18 Injection, GZR4 Injection, and GZR101 Injection Achieve Primary Endpoints in Phase 2 Clinical Studies

After 24 weeks of treatment in patients with Type 2 diabetes, the bi-weekly GLP-1 receptor agonist GZR18 injection showed superior efficacy in lowering HbA1c and body weight compared to semaglutide (Ozempic®). After 16 weeks of treatment in patients with Type 2 diabetes, the once-weekly insulin analog GZR4 injection demonstrated superior HbA1c reduction in patients with uncontrolled diabetes on basal insulins, compared to insulin degludec (Tresiba®). After 16 weeks of treatment in patients with Type 2 diabetes, the premixed dual insulin analog GZR101 injection showed superior efficacy in reducing HbA1c and postprandial glucose compared to insulin degludec/insulin aspart (Ryzodeg®). BEIJING, Oct. 15, 2024 /PRNewswire/ -- Recently, Gan & Lee Pharmaceuticals (Gan & Lee, Shanghai Stock Exchange: 603087) announced that three of its independently developed drugs — the bi-weekly GLP-1 receptor agonist GZR18 injection, the once-weekly basal insulin analog GZR4 injection, and the premixed dual insulin analog GZR101 injection — successfully achieved positive results in three Phase 2 clinical trials conducted in adult patients with Type 2 diabetes (T2D) in China. In these studies, Gan & Lee's three innovative drugs demonstrated superior or comparable efficacy in lowering glycated hemoglobin (HbA1c) compared to the respective positive comparator drugs separately. Gan & Lee Pharmaceuticals' Diabetes Product Portfolio Diagram

Clinical ResultPhase 2

20 Aug 2024

·www.echemi.com

US Drug Price Slash Coming! 9 Drugs Cut in Half, Most Drastic Drop of 79%! But the Real Truth Behind It Is Heartbreaking

Recently, the United States has announced the first 10 drug prices after negotiations under the Inflation Reduction Act (IRA). Among these drugs, the price reduction for at least 9 of them is at least 50%. Among them, the reduction in the price of diabetes treatment drugs is particularly significant: Merck's Januvia price was reduced by 79%, from $527 per month to $113; Novo Nordisk's Fiasp, a treatment drug for type 1 diabetes, was reduced by 76%, from $495 per month to $119; AstraZeneca's Farxiga (dapagliflozin) was reduced by 68%. The First List of Drug Prices Negotiated under the US IRA Act Drug Name Original Price (Monthly) Negotiated Price (Monthly) Reduction Rate Januvia 527 113 0.79 Fiasp 495 119 0.76 Farxiga (Dapagliflozin) - - 0.68 According to a research report, the implementation of the first round of drug negotiations under the US IRA Act has resulted in price reductions ranging from 38% to 79% for the covered drugs. However, due to the fact that these drugs generally have a high list price and high rebate business model, it is expected that the negotiated price reduction will have a net impact on the actual product price of around 10% to 20%. Currently, these negotiated prices only apply to Medicare patients and not to patients with commercial insurance, thus having a limited short-term financial impact on the originator pharmaceutical companies. From a long-term perspective, the IRA negotiated price reduction may lead to a shorter peak return period for individual products, prompting pharmaceutical companies to be more inclined to develop drugs with broad indications as their initial indications. Considering the long R&D cycle, in the case of a shortened peak return period, large pharmaceutical companies may accelerate their acquisition and merger activities. Based on this, the research report maintains its "outperform" rating for the domestic innovative pharmaceutical industry and recommends actively following companies that have overseas commercialization or licensing potential. Analysis of the Impact of the First Round of Drug Negotiations under the US IRA Act Reduction in Drug Prices Impact of Net Price for Actual Products Target User Short-Term Financial Impact 38%-79% 10%-20% Medicare Patient Limited In fact, in recent years, the internationalization process of China's innovative drugs has been accelerating. For example, on August 9, Merck & Co., a multinational pharmaceutical company, announced that it plans to acquire CN201, a dual antibody drug in development by Tongrun Biotech, for up to $1.3 billion in total transaction value, which is intended for the treatment of cancer and autoimmune diseases. On June 14, Yasen Pharmaceuticals announced that it will license Orebactin (trade name: Nerivac) to Takeda, according to the agreement, Yasen Pharmaceuticals will receive a $100 million option payment, and is eligible to receive up to $1.2 billion in option exercise fees and additional potential milestone payments, as well as double-digit percentage royalties based on annual sales. According to industry statistics, in 2023, a total of 156 drugs were licensed out overseas, with a total transaction value of $35 billion, of which 78 projects belong to domestic enterprises going global. Entering 2024, the number of outbound licensing transactions is still growing. Just in the first half of this year, the pharmaceutical industry has seen more than 30 outbound License-out authorizations, involving small molecules, monoclonal antibodies, and other categories. On the commercialization front, by the end of 2023, a total of six innovative drugs developed in China had been approved for the US market, and the number of approvals has shown an upward trend, with the number of approvals from 2019 to 2023 being 1, 2, and 3. The Process of China's Innovative Pharmaceuticals Industry Going Global and Its Collaboration Event Involved Companies Transaction Amount Remarks Merck Acquires Tongrun Bio's Bispecific Antibody New Drug CN201 Merck, Tongrun Bio $1.3 Billion For the treatment of cancer and autoimmune diseases Ascentage Pharma Licenses Oregovomab to Takeda Ascentage Pharma, Takeda Up to $1.3 Billion Includes option payments, royalties and milestone payments Outbound Licensing of Chinese Drugs Domestic Companies $35 Billion 2023 data, 78 projects are outbound projects of domestic companies Innovative Drugs Listed in the US Market by China - - Number of approvals from 2019 to 2023 is 1, 2, 3 respectively The report indicates that collaborating to expand overseas markets is an ideal choice for Chinese pharmaceutical companies. For the internationalization of innovative drugs, the following factors should be given priority: the potential peak sales of the drug, innovative drugs with a larger number of patients in the target indications are likely to have higher peak sales; drugs with a smaller patient base even if approved, the elasticity of performance and market capitalization is relatively limited; the clinical efficacy and the order of marketing authorization, drugs with the potential of being the best-in-class or me-better are expected to capture a higher market share, and drugs with earlier marketing authorization have certain first-mover advantages; the strength of overseas partners, considering that the dominant force in global innovative drug commercialization is still traditional pharmaceutical giants, drugs licensed to these leading companies are expected to have higher peak sales. Companies worth paying attention to include Yifan Pharmaceutical, Maiwei Biotech, and Hengrui Pharmaceutical.

License out/inDrug Approval

100 Deals associated with Insulin aspart

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KEGG	Wiki	ATC	Drug Bank
D04475	Insulin aspart	A10AD05 A10AB05	DB01306

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Diabetes Mellitus, Type 2	JP	Novo Nordisk A/S	20 Sep 2019
Diabetes Mellitus	LI	Novo Nordisk A/S	07 Sep 1999
Diabetes Mellitus	NO	Novo Nordisk A/S	07 Sep 1999
Diabetes Mellitus	EU	Novo Nordisk A/S	07 Sep 1999
Diabetes Mellitus	IS	Novo Nordisk A/S	07 Sep 1999

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Diabetes Mellitus, Type 1	Phase 3	GB	Novo Nordisk A/S	01 Sep 1997
Diabetes Mellitus, Type 1	Phase 3	DE	Novo Nordisk A/S	01 Sep 1997
Diabetes Mellitus, Type 1	Phase 3	AT	Novo Nordisk A/S	01 Sep 1997
Diabetes Mellitus, Type 1	Phase 2	CH	Novo Nordisk A/S	01 Sep 1997
Diabetes Mellitus, Type 1	Preclinical	FI	Novo Nordisk A/S	01 Sep 1997
Diabetes Mellitus, Type 1	Preclinical	NO	Novo Nordisk A/S	01 Sep 1997
Diabetes Mellitus, Type 1	Preclinical	DK	Novo Nordisk A/S	01 Sep 1997
Diabetes Mellitus, Type 1	Preclinical	DK	Novo Nordisk A/S	01 Sep 1997
Diabetes Mellitus, Type 1	Preclinical	CH	Novo Nordisk A/S	01 Sep 1997
Diabetes Mellitus, Type 1	Discovery	NO	Novo Nordisk A/S	01 Sep 1997

Clinical Result

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Phase

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04538352 (TRANSITION-T2D, CTgov)	Phase 4	Diabetes Mellitus, Type 2	60	Insulin Degludec+semaglutide+Insulin aspart (Once-weekly sc Semaglutide Combined With Once-daily Insulin)	cwihhiejvc(elnbdlpgts) = drqwlcaurb zupxnkmgms (zjuygfoqqq, urlzdrhupd - smqrbpgipg) View more	-	29 Jul 2024
				Insulin Degludec+Insulin aspart (MDI Requiring Multiple Daily Injections of Insulin)	cwihhiejvc(elnbdlpgts) = nedlbbhadb zupxnkmgms (zjuygfoqqq, wnitimmjhu - nsjewhmomr) View more
NCT04588259 (CTgov)	Phase 3	Diabetes Mellitus, Type 2 \| Diabetes Mellitus, Type 1	331	Insulin degludec+Faster aspart	ovmwfqhzic(zpjvjsnqqv) = hfcaibyspc mjhvprjvrv (gavpffshxl, ktccdrlsqj - jiozzstnce) View more	-	20 Mar 2024
NCT04460326 (In-FI, CTgov)	Phase 3	Diabetes Mellitus, Type 2	137	Insulin Glargine+NovoLog (Group 1 Insulin Glargine and Novolog)	rvuinerlvx(cvtvqmajcw) = sxjcvynyxz somggzplne (lzhgrwckrz, ausbrflzdu - fpxoolwpbn) View more	-	19 Mar 2024
				Insulin Glargine+Insulin Fiasp (Group 2 Insulin Glargine and Fiasp)	rvuinerlvx(cvtvqmajcw) = wrtpehhgzd somggzplne (lzhgrwckrz, qmbwmajyba - squakgwjrx) View more
NCT00913497 (CTgov)	Phase 4	Diabetes Mellitus, Type 1	16	insulin glulisine (Insulin Glulisine)	gnvydrwykv(cxoltjdind) = fndkmmkcti pytbzinjbt (ycqwuwdhgw, ufjljfpdjz - fllovjcqyz) View more	-	18 Sep 2023
				Insulin Aspart (Insulin Aspart)	gnvydrwykv(cxoltjdind) = dqrhahlrsm pytbzinjbt (ycqwuwdhgw, jjwfjkefby - dgxqjpjqsz) View more
NCT03895515 (Pubmed)	Not Applicable	Diabetes Mellitus, Type 1	178	Fast-Acting Insulin Aspart	(szmhujfdvv) = uhijwfdbjr zkuciprzth (cidghwvllo )	Positive	14 Jul 2023
ADA2023	Not Applicable	-	29	AT247	wtkcbygdea(dccobwpshu) = cdtmwnjnbj xgaxdkjaox (fcglgydmfa )	-	20 Jun 2023
				NovoLog	wtkcbygdea(dccobwpshu) = dovmkovase xgaxdkjaox (fcglgydmfa, *)
CopenFast Trial (ADA2023)	Not Applicable	Diabetes Mellitus, Type 1	216	Faster-acting insulin aspart	(zwqskakwrc) = zmwkhotlwt vkgzahyple (qlfavbgqhu, 38 - 46) View more	-	20 Jun 2023
				Insulin aspart	(zwqskakwrc) = fulxyichvi vkgzahyple (qlfavbgqhu, 39 - 46) View more
ADA2023	Not Applicable	-	11	Faster aspart with CC	zsgjsupshz(jeneemwhjq) = uxoachxbbs weqzwnamjt (grjifdurqy )	-	20 Jun 2023
				Faster aspart and pramlintide at a 1u:8µg ratio without CC	zsgjsupshz(jeneemwhjq) = baunsiilnl weqzwnamjt (grjifdurqy )
NCT04880850 (ONWARDS 4, Corporate Publications) Manual	Phase 3	Diabetes Mellitus, Type 2	582	Insulin aspart+Icodec Insulin	(csxqppijss) = imqkheszug nskeqbqenc (nordqmuqbs ) View more	Non-inferior	29 Jul 2022
				Insulin aspart+Insulin glargine	(csxqppijss) = cvofjbvisl nskeqbqenc (nordqmuqbs ) View more
ADA2022	Not Applicable	Diabetes Mellitus, Type 1	-	Fiasp and placebo with CC	dbxhmizvuw(mvsuqdcxlj) = nsevwintvy ubcyrdteal (kogpkgiibv )	-	01 Jun 2022
				Fiasp and pramlintide with MA	dbxhmizvuw(mvsuqdcxlj) = cyvyronudw ubcyrdteal (kogpkgiibv )

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