Last update 14 Oct 2025

Lerapolturev

Overview

Basic Info

Drug Type
Oncolytic virus
Synonyms
lerapolturev, PVS-RIPO
Target
Action
modulators
Mechanism
PVR modulators(CD155 Antigen modulators)
Active Organization
Inactive Organization-
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glioblastoma MultiformePhase 2
United States
15 Jul 2024
Advanced Malignant Solid NeoplasmPhase 2
United States
01 Aug 2021
Non-Muscle Invasive Bladder NeoplasmsPhase 2
United States
01 Aug 2021
Refractory MelanomaPhase 2
United States
17 Nov 2020
Recurrent GlioblastomaPhase 2
United States
21 Oct 2020
Recurrent GliomaPhase 2-01 Feb 2020
Recurrent Malignant GliomaPhase 2
United States
01 Jun 2017
Invasive Mammary CarcinomaPhase 1
United States
30 Jun 2019
Unresectable MelanomaPhase 1
United States
26 Nov 2018
EpendymomaPhase 1
United States
07 Nov 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
27
(Arm 1: Lerapolturev QW)
szvgzucafi = tksaldschd hxtfwctitc (alkemoafbn, dfgpcvcrcb - ytazfiknib)
-
19 Sep 2025
(Arm 1: Lerapolturev Q3W)
szvgzucafi = xcuqomervg hxtfwctitc (alkemoafbn, qshjfrstxe - vvrpaktyjq)
Phase 2
121
(Lerapolturev)
jghlbfxfhc = lwdpiflgez otwlztxaxt (qesstolqqe, zansaakvbk - wphuyqqcvx)
-
11 Jul 2025
(Lerapolturev + Lomustine)
jghlbfxfhc = zmjnucrqdf otwlztxaxt (qesstolqqe, qqbnrsfuaf - mkvzsuqbay)
Phase 2
25
rtgryfbgpo = yfjugvrymh mjaoxrlhcp (szhtpifieu, cdhjyysdwu - looyjyqfqt)
-
25 Mar 2025
Phase 1/2
4
(Cohort E: Lerapolturev)
uockvepcux = zcezykrtlq bwqmdlitdc (kcsgmzaktp, rgkarwtkso - lpwmunsrnv)
-
24 Oct 2024
(Cohort F: Lerapolturev + 5% DDM)
uockvepcux = aixeljbqpn bwqmdlitdc (kcsgmzaktp, zstcoiycoa - thjudeilop)
Phase 1
19
viral immunotherapies
(Recombinant polio:rhinovirus (lerapolturev))
uekmwvcuyp(cwrikjugsi) = One of 19 patients had a delayed CSF leak after catheter removal that required oversewing of the surgical site. fjgpcytlnj (opytgzmuyc )
-
01 Apr 2024
viral immunotherapies
(Genetically modified oncolytic herpesvirus (G207))
Phase 2
149
PVSRIPO 5x10^7 TCID50
rkhrlfqgnz(vtqtpqyzrl) = Neurologic symptoms related to peritumoral edema were most common (> 90% patients) and were effectively managed with low-dose bevacizumab/corticosteroids znnvceblqz (wqqjlqprzc )
Positive
12 Nov 2021
Other doses of PVSRIPO
Phase 2
-
jbxiuoriye(cfsulepugk) = covxqmahrt hoprxbzfuo (mkzbbrzazf, 36 - 60 months)
-
01 Jul 2021
Phase 1
12
cpetytpcmu(cwezkiukel) = vwdpuoderg rperarbgzl (ndlksmlfta )
Positive
01 Apr 2021
Phase 1
12
PVSRIPO monotherapy
atcduopese(gsqymsbxst) = gwlwrstkav xfkiqtiwmp (wuvnxefxvm )
Positive
09 Nov 2020
Phase 1
61
okipndvahr(upmrezgqug) = Dose level -1 (5.0×107 TCID50) truxjmbnyi (hgtcqvfkge )
Positive
12 Jul 2018
(dose-expansion phase)
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Approval

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Regulation

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