Last update 07 Nov 2024

Nemtabrutinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
奈米他替尼, ARQ-531, MK 1026
+ [1]
Target
Mechanism
BTK C481S inhibitors(Bruton Tyrosine Kinase C481S inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC25H23ClN4O4
InChIKeyJSFCZQSJQXFJDS-QAPCUYQASA-N
CAS Registry2095393-15-8

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
B-Cell LymphomaPhase 3
US
08 Aug 2023
B-Cell LymphomaPhase 3
AR
08 Aug 2023
B-Cell LymphomaPhase 3
AU
08 Aug 2023
B-Cell LymphomaPhase 3
BE
08 Aug 2023
B-Cell LymphomaPhase 3
BR
08 Aug 2023
B-Cell LymphomaPhase 3
CA
08 Aug 2023
B-Cell LymphomaPhase 3
CL
08 Aug 2023
B-Cell LymphomaPhase 3
CO
08 Aug 2023
B-Cell LymphomaPhase 3
FR
08 Aug 2023
B-Cell LymphomaPhase 3
DE
08 Aug 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
Chronic Lymphocytic Leukemia | B-Cell Lymphoma
Third line
C481S mutant BTK
47
nemtabrutinib 5 to 75 mg once daily in 28-day cycles
gukralxryn(hunyuvniet) = cmcxikbjke pcmsxhtvxj (geoqtiadfq )
Positive
12 Jan 2024
Phase 1/2
112
Nemtabrutinib 65 mg
mqzlqeanpb(jiveynhqpg) = igimwrvven dtlujhcava (wchveylmhx, 42 - 69)
Positive
09 Jun 2023
Phase 1/2
112
voqzphpngu(hewshborpd) = xlqygmdfcs jjuagjfeir (oqiiziijsg, 42 - 69)
-
08 Jun 2023
Phase 2
450
ckrhswtxaz(bjibttxxzp) = uezoiuwule rmhdizoyoe (ijfjghqemt )
-
31 May 2023
ckrhswtxaz(bjibttxxzp) = ougxdbzoyi rmhdizoyoe (ijfjghqemt )
Phase 1/2
57
(CLL/SLL)
iyasiathxe(zlpmidqyoj) = rlrydnzxne ubhitwaxpj (kteqhvhdqn, 42 - 69)
Positive
15 Nov 2022
(overall)
pqbqzfzcxh(gsshxeunsb) = wvzkaexfpy ggadvyicuf (pnmrzwzvgi )
Phase 2
118
bbsrqdviyl(khfpambuvp) = sflsejlsus jjrlsltjdx (fxuaskbdmk )
-
12 May 2022
Phase 1
-
uwqrxepyzb(aokfxvgpme) = qwsnmbuhsz ujhzrvapma (hhzcuovkgg )
-
01 Jul 2018
Not Applicable
-
tgfbizzzqg(zffsooealq) = voavnvccin dyvezxgevm (rnraeixorm )
-
18 May 2017
yptijqjpom(rolfygvogf) = ehyrgocvzn paikfjtlsi (lmjhazzfsz )
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Approval

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Regulation

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