Delving into the Latest Updates on Recombinant interferon alfa-2b/Diphenhydramine with Synapse

Overview

Basic Info

Drug Type

Interferons

Synonyms

2-(benzhydryloxy)-N,N-dimethylethylamine, 2-diphenylmethoxy-N,N-demthylethanamine, Diphenhydramine

+ [6]

Target

H1 receptor x IFNAR

Action

inverse agonists, agonists

Mechanism

H1 receptor inverse agonists(Histamine H1 receptor inverse agonists), IFNAR agonists(Interferon alpha/beta receptor agonists)

Therapeutic Areas

Eye Diseases

Active Indication

Conjunctivitis

Inactive Indication-

Originator Organization

Firn M Zao

Active Organization

Firn M Zao

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

Russia (01 Oct 2008),

Conjunctivitis

Regulation-

Login to view timeline

Structure/Sequence

Molecular FormulaC17H21NO

InChIKeyZZVUWRFHKOJYTH-UHFFFAOYSA-N

CAS Registry58-73-1

A new gas-diffusion electrode (GDE) has been developed and optimized to apply the heterogeneous electro-Fenton (EF) process to the degradation of the antihistamine diphenhydramine.The complete removal of this hazardous drug pollutant was achieved within only 120 min in actual urban wastewater at pH 5.9.Nitrogen-doped carbon electrocatalysts were first synthesized by direct pyrolysis of blends of com. Vulcan carbon and melamine as nitrogen dopant.A radar chart was proposed to correlate the tested physicochem. and electrochem. properties.A well-balanced surface area, mesopores volume and defective carbon content were critical to ensure the highest activity (E_onset = 0.38 V vs. RHE) and selectivity (n ∼ 2, y_H2O2 ∼ 95.3 %) for two-electron oxygen reduction reaction (ORR), which allowed the efficient in-situ production of H₂O₂ as ^·OH precursor.N-doping (10.5 wt%), along with the presence of pyrrolic N (3.5 %), are also key factors to explain the enhancement.GDEs fabricated with the optimal electrocatalyst (71.4 wt% melamine content) were capable of accumulating up to ∼35 mM H₂O₂ within 5 h, outperforming the com. GDEs.This work evidences the interplay of physicochem. and electrocatalytic parameters in H₂O₂-based advanced water treatment, demonstrating that it is possible to envisage a more efficient and greener tertiary wastewater treatment.

01 Jun 2025·Food Chemistry

High-throughput screening of new psychoactive substances and related compounds in food by UHPLC-Q/Orbitrap

Article

Author: Wu, Wenlin ; Huang, Xia ; Liu, Shiyao ; Chen, Xiaoqi ; Zhou, Yan ; Wan, Yuping ; Xia, Bing ; Guo, Tianrong ; Shi, Peiyu ; Xiao, Quanwei ; Zhang, Min

Currently, there is concern about food products to which new psychoactive substances (NPS) have been added illegally. However, rapid, high-sensitivity, and high-throughput screening methods for such harmful substances have not been reported yet. In this study, a high-throughput non-targeted screening strategy was developed based on UHPLC-Q/Orbitrap. First, optimized pretreatment methods for typical high-risk matrices were established. Second, an accurate, efficient, and scalable high resolution mass spectrometry database containing 206 NPS and related compounds was constructed. The fragmentation pathways of three different types of fentanyl-related compounds were then systematically investigated to enhance compound identification. Additionally, a non-targeted screening strategy was developed using warning ions derived from 24 fentanyl-related compounds, streamlining the identification of NPS. This strategy was applied to 100 food samples with possible illegal additives and demonstrated its effectiveness. In summary, this study provides robust technical support for regulatory authorities in combating the illegal addition of food products.

01 May 2025·Skeletal Radiology

Correction to: Rhabdomyolysis following diphenhydramine overdose—a case report

Author: Karatas, Rifat ; Silva, Flavio Duarte ; Taneja, Atul Kumar ; Basha, Adil ; Chhabra, Avneesh

100 Deals associated with Recombinant interferon alfa-2b/Diphenhydramine

Login to view more data

External Link

KEGG	Wiki	ATC	Drug Bank
-	Recombinant interferon alfa-2b/Diphenhydramine	R06AA52	DB01075

R&D Status

10 top approved records.

Login

to view more data

Indication	Country/Location	Organization	Date
Conjunctivitis	Russia	Firn M Zao	01 Oct 2008

Login to view more data

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ASN2020	Not Applicable	Chronic Kidney Diseases	353	Allopurinol	sfshxuahat(trwxjirwhu) = fygatcvcws dzkjeyicnz (vrfovrmfys ) View more	Negative	19 Oct 2020
				Colchicine	sfshxuahat(trwxjirwhu) = vdcujlukuf dzkjeyicnz (vrfovrmfys ) View more
AAAAI2014	Not Applicable	-	-	diphenhydramine (Adults)	ztbrbvdxan(hlmhbeplgb) = pmmcczfeqm ohdgoldghf (bwwjqgwalz ) View more	-	01 Feb 2014
				diphenhydramine (Children)	ztbrbvdxan(hlmhbeplgb) = znbwmfdtds ohdgoldghf (bwwjqgwalz ) View more
AAAAI2010	Not Applicable	-	-	Cetirizine	ynazjcmgyc(zgrhxqosds) = ayeikwkbgl reafdnjufb (yddqdezzag )	-	01 Feb 2010
				OTC loratadine	ynazjcmgyc(zgrhxqosds) = wiqlaoueuh reafdnjufb (yddqdezzag )

Login to view more data

Translational Medicine

Boost your research with our translational medicine data.

login

or

view full example data

Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.

login

or

view full example data

Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.

login

or

view full example data

Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.

login

or

view full example data

Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.

login

or

view full example data

Accelerate your research with the latest regulatory approval information.

Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

login

or

view full example data