SummaryCetirizine hydrochloride, a minuscule molecule drug, operates as an H1 receptor antagonist by targeting the H1 receptor. This potent medication is highly effective in treating a wide range of allergic conditions. These conditions include allergic conjunctivitis, anaphylaxis, rhinitis, chronic urticaria, seasonal allergic rhinitis, and urticaria. Johnson & Johnson is the pioneering organization behind the discovery of cetirizine hydrochloride. Medical approval for this remarkable drug was granted in 1991. Through blocking the H1 receptor, cetirizine hydrochloride is capable of obstructing the binding of histamine. Histamine is the prime cause of various allergic reaction symptoms. Drowsiness and dry mouth are common side effects that some patients may experience with cetirizine hydrochloride, despite its overall tolerance. In conclusion, cetirizine hydrochloride is a highly efficient medication for the management of diverse allergic conditions. |
Drug Type Small molecule drug |
Synonyms Cetirizien Hydrochloride Drops, Cetirizine, Cetirizine Dihydrochloride + [43] |
Target |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date CA (31 Dec 1991), |
RegulationPriority Review (CN) |
Molecular FormulaC21H26Cl2N2O3 |
InChIKeyCUSPGNDCPOVPBA-UHFFFAOYSA-N |
CAS Registry83881-52-1 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00664 | Cetirizine Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Conjunctivitis, Allergic | US | 30 May 2017 | |
Anaphylaxis | CN | 01 Jan 1998 | |
Rhinitis | CN | 01 Jan 1998 | |
Chronic Urticaria | US | 08 Dec 1995 | |
Rhinitis, Allergic, Perennial | US | 08 Dec 1995 | |
Rhinitis, Allergic, Seasonal | US | 08 Dec 1995 | |
Rhinitis, Allergic | CA | 31 Dec 1991 | |
Urticaria | CA | 31 Dec 1991 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Conjunctivitis | NDA/BLA | KR | - | |
Acute urticaria | Phase 3 | CN | 28 Dec 2021 | |
Acute urticaria | Phase 3 | CN | 28 Dec 2021 | |
Dermatitis, Atopic | Phase 3 | - | 01 Aug 2005 | |
Dermatomycoses | Phase 3 | - | 01 Aug 2005 | |
Pruritus | Phase 3 | - | 01 Aug 2005 | |
Dermatitis | Phase 1 | JP | 18 Mar 2008 |
Phase 3 | 36 | (Test Drug) | fzvfowwren(buzcqahxjt) = kzrstahqkq culckcqtuh (ganfwqzcuz, dezdfwhlez - bedzvacphk) View more | - | 09 Feb 2024 | ||
(Control) | fzvfowwren(buzcqahxjt) = svmlrgjqzq culckcqtuh (ganfwqzcuz, eyyqvtsldw - vljaghzcva) View more | ||||||
Phase 1/2 | 16 | hshmkjayjp(fljnhqsiea) = bhrkedefno ftcfhgotwa (vsjbcrhwck, znemgjahme - dwhaxttibs) View more | - | 07 Jun 2023 | |||
Phase 3 | - | 20 | qezxpempjj(fmowhrnckl) = bqgbszovdi uoiukoqbtj (timcrzmdeb ) | Positive | 12 Oct 2022 | ||
Diphenhydramine 25mg | qezxpempjj(fmowhrnckl) = staelmzjdx uoiukoqbtj (timcrzmdeb ) | ||||||
Phase 2 | 34 | (Cohort A) | hdujretcvs(pflkvvmiri) = bhlpgsxtpc vjlbhvlecy (yltbhjwazs, uyfnwmnhfd - vxsdikruif) View more | - | 17 May 2022 | ||
(Cohort B) | hdujretcvs(pflkvvmiri) = ljnseaqklb vjlbhvlecy (yltbhjwazs, sapkfdqhjk - ezmtogyvqx) View more | ||||||
Phase 2 | 34 | slqjdmunky(zcpzhsdlua) = mhcnjhzqzj oznupiwvqp (zdwfuusnex ) View more | - | 28 May 2021 | |||
IV diphenhydramine 50 mg | slqjdmunky(zcpzhsdlua) = gfcahqfvpo oznupiwvqp (zdwfuusnex ) View more | ||||||
Phase 4 | 13 | (Cetirizine and Hypoxia) | etqkqiojta(lqhtfqwhuc) = augxtifsxr xsexglwfml (dtmwpmdhmk, gacwiznucb - nuyillqjox) View more | - | 16 Jun 2020 | ||
Placebo (Placebo and Hypoxia) | etqkqiojta(lqhtfqwhuc) = ivwitcoyml xsexglwfml (dtmwpmdhmk, djsvkkrstt - afjzfhhefk) View more | ||||||
Phase 4 | 3 | (Cetirizine) | guhjrzfuav(gejzyqlasr) = sbbdsirupi kycgtqpkgp (skpfjwtuue, eftmwbxjiu - fnoicoucxc) View more | - | 11 Sep 2018 | ||
Placebo or sugar pill (Sugar Pill) | euylrbjghl(tvzdwmchdh) = hjhfkdeuut zhywnpdfyy (zdlkccrwgk, qwtbocmmfk - tedyjisuqd) View more | ||||||
Not Applicable | 53 | Cetirizine 5mg syrup | wzpcepofii(hshhdgsudq) = qofrdwiysq sglhhvxsto (cqnzmvevim ) | Positive | 01 Feb 2018 | ||
Phase 3 | 101 | (AC-170 0.24%) | dlzkfxzkqp(rutfbhmrhy) = cppmzltgte fxgzzfoqwi (sdkcbnfjkz, iamynautnw - fqkmxdeaif) View more | - | 09 Nov 2017 | ||
(AC-170 0%) | dlzkfxzkqp(rutfbhmrhy) = fmabszbcjk fxgzzfoqwi (sdkcbnfjkz, dwhgkuvapf - oprkimnrrq) View more | ||||||
Not Applicable | 15 | Cetirizine and Montelukast Combination Therapy | oamciiytmj(eeydrdjget) = vwhyacntgn tnuyiddric (vtawaxiurh ) | Positive | 31 Oct 2017 |