Last update 29 Jun 2024

Cetirizine Hydrochloride

Overview

Basic Info

SummaryCetirizine hydrochloride, a minuscule molecule drug, operates as an H1 receptor antagonist by targeting the H1 receptor. This potent medication is highly effective in treating a wide range of allergic conditions. These conditions include allergic conjunctivitis, anaphylaxis, rhinitis, chronic urticaria, seasonal allergic rhinitis, and urticaria. Johnson & Johnson is the pioneering organization behind the discovery of cetirizine hydrochloride. Medical approval for this remarkable drug was granted in 1991. Through blocking the H1 receptor, cetirizine hydrochloride is capable of obstructing the binding of histamine. Histamine is the prime cause of various allergic reaction symptoms. Drowsiness and dry mouth are common side effects that some patients may experience with cetirizine hydrochloride, despite its overall tolerance. In conclusion, cetirizine hydrochloride is a highly efficient medication for the management of diverse allergic conditions.
Drug Type
Small molecule drug
Synonyms
Cetirizien Hydrochloride Drops, Cetirizine, Cetirizine Dihydrochloride
+ [43]
Mechanism
H1 receptor antagonists(Histamine H1 receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
CA (31 Dec 1991),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC21H26Cl2N2O3
InChIKeyCUSPGNDCPOVPBA-UHFFFAOYSA-N
CAS Registry83881-52-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Conjunctivitis, Allergic
US
30 May 2017
Anaphylaxis
CN
01 Jan 1998
Rhinitis
CN
01 Jan 1998
Chronic Urticaria
US
08 Dec 1995
Rhinitis, Allergic, Perennial
US
08 Dec 1995
Rhinitis, Allergic, Seasonal
US
08 Dec 1995
Rhinitis, Allergic
CA
31 Dec 1991
Urticaria
CA
31 Dec 1991
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
ConjunctivitisNDA/BLA
KR
-
Acute urticariaPhase 3
CN
28 Dec 2021
Acute urticariaPhase 3
CN
28 Dec 2021
Dermatitis, AtopicPhase 3-01 Aug 2005
DermatomycosesPhase 3-01 Aug 2005
PruritusPhase 3-01 Aug 2005
DermatitisPhase 1
JP
18 Mar 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
36
fzvfowwren(buzcqahxjt) = kzrstahqkq culckcqtuh (ganfwqzcuz, dezdfwhlez - bedzvacphk)
-
09 Feb 2024
fzvfowwren(buzcqahxjt) = svmlrgjqzq culckcqtuh (ganfwqzcuz, eyyqvtsldw - vljaghzcva)
Phase 1/2
16
hshmkjayjp(fljnhqsiea) = bhrkedefno ftcfhgotwa (vsjbcrhwck, znemgjahme - dwhaxttibs)
-
07 Jun 2023
Phase 3
-
20
qezxpempjj(fmowhrnckl) = bqgbszovdi uoiukoqbtj (timcrzmdeb )
Positive
12 Oct 2022
Diphenhydramine 25mg
qezxpempjj(fmowhrnckl) = staelmzjdx uoiukoqbtj (timcrzmdeb )
Phase 2
34
hdujretcvs(pflkvvmiri) = bhlpgsxtpc vjlbhvlecy (yltbhjwazs, uyfnwmnhfd - vxsdikruif)
-
17 May 2022
hdujretcvs(pflkvvmiri) = ljnseaqklb vjlbhvlecy (yltbhjwazs, sapkfdqhjk - ezmtogyvqx)
Phase 2
34
slqjdmunky(zcpzhsdlua) = mhcnjhzqzj oznupiwvqp (zdwfuusnex )
-
28 May 2021
IV diphenhydramine 50 mg
slqjdmunky(zcpzhsdlua) = gfcahqfvpo oznupiwvqp (zdwfuusnex )
Phase 4
13
(Cetirizine and Hypoxia)
etqkqiojta(lqhtfqwhuc) = augxtifsxr xsexglwfml (dtmwpmdhmk, gacwiznucb - nuyillqjox)
-
16 Jun 2020
Placebo
(Placebo and Hypoxia)
etqkqiojta(lqhtfqwhuc) = ivwitcoyml xsexglwfml (dtmwpmdhmk, djsvkkrstt - afjzfhhefk)
Phase 4
3
(Cetirizine)
guhjrzfuav(gejzyqlasr) = sbbdsirupi kycgtqpkgp (skpfjwtuue, eftmwbxjiu - fnoicoucxc)
-
11 Sep 2018
Placebo or sugar pill
(Sugar Pill)
euylrbjghl(tvzdwmchdh) = hjhfkdeuut zhywnpdfyy (zdlkccrwgk, qwtbocmmfk - tedyjisuqd)
Not Applicable
53
Cetirizine 5mg syrup
wzpcepofii(hshhdgsudq) = qofrdwiysq sglhhvxsto (cqnzmvevim )
Positive
01 Feb 2018
Phase 3
101
(AC-170 0.24%)
dlzkfxzkqp(rutfbhmrhy) = cppmzltgte fxgzzfoqwi (sdkcbnfjkz, iamynautnw - fqkmxdeaif)
-
09 Nov 2017
(AC-170 0%)
dlzkfxzkqp(rutfbhmrhy) = fmabszbcjk fxgzzfoqwi (sdkcbnfjkz, dwhgkuvapf - oprkimnrrq)
Not Applicable
15
Cetirizine and Montelukast Combination Therapy
oamciiytmj(eeydrdjget) = vwhyacntgn tnuyiddric (vtawaxiurh )
Positive
31 Oct 2017
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