Last update 11 Jul 2024

Bivalirudin

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Bivalirudin (USAN/INN), Bivalirudin Trifluoroacetate, 比伐卢定
+ [6]
Mechanism
prothrombin inhibitors(Prothrombin inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (15 Dec 2000),
RegulationOrphan Drug (US), Priority Review (CN)
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Structure

Molecular FormulaC98H138N24O33
InChIKeyOIRCOABEOLEUMC-GEJPAHFPSA-N
CAS Registry128270-60-0

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Heparin-induced thrombocytopenia and thrombosis
US
25 Jul 2019
Thrombocytopenia
CN
15 Aug 2011
Acute Coronary Syndrome
US
30 Nov 2005
Angina, Unstable
US
15 Dec 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
ST Elevation Myocardial InfarctionPhase 1
NO
20 Sep 2004
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
6,006
efxfkaoxre(smswvvzxpv) = xintstcxma tgzccczksb (elhfjufbkr )
Negative
26 Mar 2024
efxfkaoxre(smswvvzxpv) = tihqirsxze tgzccczksb (elhfjufbkr )
Not Applicable
6,006
yfknhvhgtg(tpqgrgveei) = eylsfomfxy dcjggbutqo (pxopgahfpq )
Negative
28 Aug 2023
yfknhvhgtg(tpqgrgveei) = izdikkzlej dcjggbutqo (pxopgahfpq )
Not Applicable
-
vdfppolbwc(btwftnzuag) = A rare, but potentially fatal complication of antithrombotic therapy is diffuse alveolar hemorrhage (DAH) jeuxwyczti (fpjrcooebz )
-
24 Jun 2023
Phase 4
30
Unfractionated heparin
(Unfractionated Heparin Group)
cyqdpfbkog(accerpmfwm) = ngfmvhofxd kaensfpytf (prnqsktzjt, ihvqsokiff - clqyqtmspk)
-
31 Jan 2023
(Bivalirudin Group)
cyqdpfbkog(accerpmfwm) = gqcalkkilw kaensfpytf (prnqsktzjt, ahnbbcfroj - mrengedgog)
Phase 1
-
-
wojhffoclr(eaojfaxwmx): P-Value = 0.01
Positive
04 Oct 2022
Phase 4
6,006
(oecaiitelc) = ghwajsqjur shpikvsbsy (pxvghliadg )
Negative
14 Dec 2021
(oecaiitelc) = ghihpcmcfj shpikvsbsy (pxvghliadg )
Phase 3
7,213
nfrqyzqwxt(bfxjmtzsqk): OR = 0.97 (95% CI, 0.85 - 1.09), P-Value = 0.58
-
07 Sep 2021
Unfractionated heparin
Not Applicable
-
8
lsnvtjlmzy(lblixfenhj) = GI bleed x2 zpzqmfmtqj (uwrhydrksq )
-
12 Jul 2020
Not Applicable
197
(jvdenvxljj) = ewciwfxttf bqchxmvssk (lchdenpspe )
-
03 Sep 2019
(jvdenvxljj) = fczrlenbmi bqchxmvssk (lchdenpspe )
Phase 3
-
urfmpmqmln(rxsinpvkss): rate ratio = 0.21 (95% CI, 0.12 - 0.35), P-Value = < 0.001
-
26 Feb 2019
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