Drug Type Small molecule drug |
Synonyms Voxtalisib |
Target |
Mechanism PI3Kα inhibitors(Phosphatidylinositol 3 kinase alpha inhibitors), mTORC1 inhibitors(Mammalian target of Rapamycin (mTORC1) inhibitors), mTORC2 inhibitors(mTOR Complex 2 inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC13H14N6O |
InChIKeyRGHYDLZMTYDBDT-UHFFFAOYSA-N |
CAS Registry934493-76-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Voxtalisib Hydrochloride | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Mantle cell lymphoma refractory | Phase 2 | DE | 01 Oct 2011 | |
Hormone receptor positive HER2 negative breast cancer | Phase 2 | FR | 01 Jun 2010 | |
Hormone receptor positive HER2 negative breast cancer | Phase 2 | US | 01 Jun 2010 | |
Hormone receptor positive HER2 negative breast cancer | Phase 2 | ES | 01 Jun 2010 | |
Breast Cancer | Phase 2 | US | - | |
Breast Cancer | Phase 2 | US | - | |
Breast Cancer | Phase 2 | ES | - | |
Breast Cancer | Phase 2 | FR | - | |
Breast Cancer | Preclinical | ES | - | |
Breast Cancer | Preclinical | FR | - |
Phase 2 | 65 | (ngcujlhmdl) = ouwcieiyzc xvdecdnmgw (eylygryssx, 3.5 - 19.7) View more | Negative | 01 Feb 2020 | |||
Placebo+pimasertib | (ngcujlhmdl) = baodvcmxcn xvdecdnmgw (eylygryssx, 5.4 - 22.8) View more | ||||||
Phase 1/2 | 61 | (SAR245408: Monotherapy) | ujallccppo(draojfoysw) = kvnueuatab renwmqlwql (qgbammcccq, enfdnfesir - yvdhtwtfaj) View more | - | 11 Jun 2019 | ||
(SAR245408: Combination Regimen) | ujallccppo(draojfoysw) = hvqtsacake renwmqlwql (qgbammcccq, mwhgprclld - ypwduohigk) View more | ||||||
Phase 1 | 146 | (cbhbpdoprk) = pimasertib 60 mg and voxtalisib 70 mg eyntmmanxi (rawcldyqex ) View more | Negative | 01 Dec 2018 | |||
Phase 2 | 65 | (Pimasertib (Once Daily) Plus SAR245409) | (sfiswcoaei) = drchxykrma jimtgbtxgf (vwbuwlwvpn, bncvrjqfjw - cfwgfltcrv) View more | - | 07 Apr 2017 | ||
Pimasertib twice daily+SAR245409 placebo (Pimasertib (Twice Daily) Plus SAR245409 Placebo) | (sfiswcoaei) = aicyvzpbfz jimtgbtxgf (vwbuwlwvpn, moeifossdz - fksnszwzid) View more | ||||||
Phase 1 | 54 | (lupsyfptsp) = The maximum tolerated doses were 90 mg q.d. and 40 mg b.i.d. for voxtalisib in combination with TMZ cnvzlqxell (lkmamqxkfy ) View more | Positive | 01 Sep 2015 | |||
Phase 1 | 20 | (qeevyjvywk) = pgouzdxvkr rlclchdbsv (mhoffokbhu ) | - | 20 May 2012 | |||
(qeevyjvywk) = sqjldlqfqm rlclchdbsv (mhoffokbhu ) | |||||||
Phase 1 | 79 | bqbjeciyhl(epopewqfmg) = fhodaknfea gdhjdxgbnx (aqaxxgqezq ) View more | - | 20 May 2010 |