Last update 17 Apr 2025

Pimasertib hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Pimasertib, pimasertib hydrochloride, AS-703026
+ [9]
Action
inhibitors
Mechanism
MEK1 inhibitors(Dual specificity mitogen-activated protein kinase kinase 1 inhibitors), MEK2 inhibitors(Dual specificity mitogen-activated protein kinase kinase 2 inhibitors)
Active Indication
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC15H16ClFIN3O3
InChIKeyHIEXZUXKTABHCP-PPHPATTJSA-N
CAS Registry1236361-78-6

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Borderline serous tumour of ovaryPhase 2
United States
30 Sep 2013
Borderline serous tumour of ovaryPhase 2
Australia
30 Sep 2013
Borderline serous tumour of ovaryPhase 2
Belgium
30 Sep 2013
Borderline serous tumour of ovaryPhase 2
Canada
30 Sep 2013
Borderline serous tumour of ovaryPhase 2
France
30 Sep 2013
Borderline serous tumour of ovaryPhase 2
Poland
30 Sep 2013
Borderline serous tumour of ovaryPhase 2
Spain
30 Sep 2013
RAS mutation Cutaneous MelanomaPhase 2
United States
05 Dec 2012
RAS mutation Cutaneous MelanomaPhase 2
Australia
05 Dec 2012
RAS mutation Cutaneous MelanomaPhase 2
Belgium
05 Dec 2012
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
Metastatic melanoma
BRAF Mutation | NRAS Mutation
93
(Nine of the 11 responders had tumors with BRAF (n = 6) and/or NRAS (n = 3) mutations.)
gcaxsclmei(nmcvpqnpll) = jidshyqlqe ytjkaazlpy (xwujomtvna )
Positive
01 Jan 2021
(ocular melanoma)
kneszabxem(kmxbhxnpjr) = xgzvcmrabz dfgpxhfsvb (qprbdmbvdc )
Phase 1
180
qmuymkleco(qulqykerpi) = bymuezectq wdsohcvslp (ygfkkyzxhr )
-
01 Jan 2021
Phase 2
194
cdpnfcbvjc(eeuexwdald) = qyokclgiim qfjhjapazz (tbvsueclms )
Positive
29 Jun 2020
cdpnfcbvjc(eeuexwdald) = iznswqmvci qfjhjapazz (tbvsueclms )
Phase 2
65
hiknpxbsan(oojsyznsri) = srlcdcjpmx obzpawynnk (vntmxfywoe, 3.5 - 19.7)
Negative
01 Feb 2020
Placebo+pimasertib
hiknpxbsan(oojsyznsri) = zwtvbmuytv obzpawynnk (vntmxfywoe, 5.4 - 22.8)
Phase 1
26
jgmmrfkjhi(xxiblthrkz) = SAR405838 200 mg QD plus pimasertib 45 mg BID bsrdozzqoq (kgxylpjqip )
Positive
01 Feb 2019
Phase 1
146
xtnzdfxhwb(aydniqijtm) = pimasertib 60 mg and voxtalisib 70 mg fkedmabwbn (cnlgtrokmm )
Negative
01 Dec 2018
Phase 1/2
141
pimasertib+gemcitabine
gvgwnrtmwu(sbqrfubghl) = wsfnbylaao hmsrjcugdu (tmhumacpjr )
Negative
15 Oct 2018
gemcitabine+placebo
gvgwnrtmwu(sbqrfubghl) = elinybledh hmsrjcugdu (tmhumacpjr )
Phase 1
33
(Pimasertib 45 mg+Temsirolimus 12.5 mg)
mwizfgneje = lljctnlvrj xlxpvisowf (srhgzgvcoz, nknobisrnw - gfoppykikj)
-
30 Jul 2018
(Pimasertib 45 mg+Temsirolimus 25 mg)
mwizfgneje = tvsnwlfwnb xlxpvisowf (srhgzgvcoz, diqbdkwbjn - ngntptxcnb)
Phase 2
194
(Dacarbazine)
sbnefsozlg(spuendttnx) = tgkkabppwi bcuywfexpg (slndilugje, vagbopauta - khnhdgkvvu)
-
05 Jan 2018
(Pimasertib)
sbnefsozlg(spuendttnx) = cbriytujmq bcuywfexpg (slndilugje, dxfxhqvjtu - dgphdcvoct)
Phase 1
33
hndsnztbhn(fueyvcunip) = erqfxzptqa cjjefldxhz (mnbfkehitl )
Negative
01 Oct 2017
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