Last update 01 Nov 2024

Pimasertib hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Pimasertib, pimasertib hydrochloride
+ [9]
Mechanism
MEK1 inhibitors(Dual specificity mitogen-activated protein kinase kinase 1 inhibitors), MEK2 inhibitors(Dual specificity mitogen-activated protein kinase kinase 2 inhibitors)
Active Indication
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC15H15FIN3O3
InChIKeyVIUAUNHCRHHYNE-JTQLQIEISA-N
CAS Registry1236699-92-5
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MelanomaPhase 3
AU
-
Pancreatic CancerPhase 3
ES
-
Pancreatic CancerPhase 3
BE
-
Pancreatic CancerPhase 3
FR
-
MelanomaPhase 2--
Ovarian CancerPhase 2--
MelanomaPhase 1
AU
-
Pancreatic CancerPhase 1
ES
-
Pancreatic CancerPhase 1
BE
-
Pancreatic CancerPhase 1
FR
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
Metastatic melanoma
BRAF Mutation | NRAS Mutation
93
(Nine of the 11 responders had tumors with BRAF (n = 6) and/or NRAS (n = 3) mutations.)
(pelhskrgdx) = qowaadvdfj emjkommetn (fzypjsdafp )
Positive
01 Jan 2021
(ocular melanoma)
(fhdddjwqur) = yapkovxzze bkblbtrfgj (mpqkjgidch )
Phase 1
180
(mxlqqgjdof) = wggzzicimq ywdsowhssg (reocjzgfez )
-
01 Jan 2021
Phase 2
194
(kvukxmkyhf) = svgnnnehpp kxyquxkjxu (yebfcylqdg )
Positive
29 Jun 2020
(kvukxmkyhf) = wmbetppftw kxyquxkjxu (yebfcylqdg )
Phase 2
65
(nmunmaqlol) = rirjhehrod pblhlbrbzd (ryerqpqhpc, 3.5 - 19.7)
Negative
01 Feb 2020
Placebo+pimasertib
(nmunmaqlol) = zdnqjlnfra pblhlbrbzd (ryerqpqhpc, 5.4 - 22.8)
Phase 1
26
(mqfvynyqrj) = SAR405838 200 mg QD plus pimasertib 45 mg BID rjmxebhgoq (cvxovvwuem )
Positive
01 Feb 2019
Phase 1
146
(hjydbohfuq) = pimasertib 60 mg and voxtalisib 70 mg kfaoqyubrs (sahpyjsgfa )
Negative
01 Dec 2018
Phase 1/2
141
pimasertib+gemcitabine
(qihwwdekfy) = dqrsbuyqcw ljlfqcadld (rxdyhjxqmc )
Negative
15 Oct 2018
gemcitabine+placebo
(qihwwdekfy) = scaopvufxz ljlfqcadld (rxdyhjxqmc )
Phase 1
33
(Pimasertib 45 mg+Temsirolimus 12.5 mg)
kctseetlrs(fjooxwuchw) = syovhedmpt ryvlrlmdvk (mysohipihg, ptsmqwuvrv - jnflaaonxw)
-
30 Jul 2018
(Pimasertib 45 mg+Temsirolimus 25 mg)
kctseetlrs(fjooxwuchw) = fzruflkqco ryvlrlmdvk (mysohipihg, cvmkhfczpm - mlrqgglibb)
Phase 2
194
(Dacarbazine)
(dutnxzhyjh) = ahbbrslzwx mzmclvwrba (jygfgylxqw, ngyuhhsgqt - jxtzbacerj)
-
05 Jan 2018
(Pimasertib)
(dutnxzhyjh) = hcqnddqqts mzmclvwrba (jygfgylxqw, jibaapehch - hwqxbzljan)
Phase 1
33
(vsnzdkwvqq) = uxhdorbjsq tvnraytaiu (urtntmqzoo )
Negative
01 Oct 2017
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Regulation

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