Last update 21 Nov 2024

Pimasertib hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Pimasertib, pimasertib hydrochloride
+ [9]
Mechanism
MEK1 inhibitors(Dual specificity mitogen-activated protein kinase kinase 1 inhibitors), MEK2 inhibitors(Dual specificity mitogen-activated protein kinase kinase 2 inhibitors)
Active Indication
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC15H15FIN3O3
InChIKeyVIUAUNHCRHHYNE-JTQLQIEISA-N
CAS Registry1236699-92-5
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pancreatic CancerPhase 2
ES
-
Pancreatic CancerPreclinical
FR
-
Pancreatic CancerPreclinical
ES
-
Pancreatic CancerPreclinical
BE
-
Pancreatic CancerPreclinical
FR
-
Pancreatic CancerPreclinical
GB
-
Pancreatic CancerPreclinical
US
-
Pancreatic CancerDiscovery
US
-
Pancreatic CancerDiscovery
GB
-
Pancreatic CancerDiscovery
BE
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
Metastatic melanoma
BRAF Mutation | NRAS Mutation
93
(Nine of the 11 responders had tumors with BRAF (n = 6) and/or NRAS (n = 3) mutations.)
(itvjfczocv) = kqqmysuyti rpylvrnwta (iswveukbix )
Positive
01 Jan 2021
(ocular melanoma)
(lizlyxuqbs) = bprhvlxijq zqwlcucned (huyvubdkkn )
Phase 1
180
(rhiycwzqjr) = kochllxkox xgkmjdromm (jvdhzyecxe )
-
01 Jan 2021
Phase 2
194
(fqmgrfknmt) = monnpbaous xdylytgchy (hxforlbtcw )
Positive
29 Jun 2020
(fqmgrfknmt) = flmutkgkqu xdylytgchy (hxforlbtcw )
Phase 2
65
(rknnftmnob) = fblmbkfzzo xrccrkcivt (vfrbeoyjqj, 3.5 - 19.7)
Negative
01 Feb 2020
Placebo+pimasertib
(rknnftmnob) = ncjjbqezlw xrccrkcivt (vfrbeoyjqj, 5.4 - 22.8)
Phase 1
26
(teppzkrzdb) = SAR405838 200 mg QD plus pimasertib 45 mg BID qsqanrlykf (xbnuyrkwze )
Positive
01 Feb 2019
Phase 1
146
(khsppqeckw) = pimasertib 60 mg and voxtalisib 70 mg vpaxpuqdzu (qkrbifxruw )
Negative
01 Dec 2018
Phase 1/2
141
pimasertib+gemcitabine
(kjuzllaozm) = bcrhlpwbsd xmgvvixxjw (vycvvkreil )
Negative
15 Oct 2018
gemcitabine+placebo
(kjuzllaozm) = tvexclijhb xmgvvixxjw (vycvvkreil )
Phase 1
33
(Pimasertib 45 mg+Temsirolimus 12.5 mg)
pupdghnino(iugwtpdaue) = odrvxrvxvi xuuojachte (yfyxlceylt, xuwsruhyci - dibbcdsuss)
-
30 Jul 2018
(Pimasertib 45 mg+Temsirolimus 25 mg)
pupdghnino(iugwtpdaue) = xajsxayclk xuuojachte (yfyxlceylt, pneoovshja - iycgeandgy)
Phase 2
194
(Dacarbazine)
(ocrcetemhk) = ggmsdvkaoq pvteiuhcoj (zvovhwozdl, qzttlsabji - cofttmywvt)
-
05 Jan 2018
(Pimasertib)
(ocrcetemhk) = shohwpmdoe pvteiuhcoj (zvovhwozdl, zdfhitdmbt - vpoljtogsa)
Phase 1
33
(oicmwncues) = tnrxeleird vkkzpeowvb (vmjnowvbtr )
Negative
01 Oct 2017
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