Last update 21 Nov 2024

Domperidone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Deudomperidone, Domperidone (JP17/USAN/INN), deuterated domperidone (CinRx Pharma)
+ [8]
Mechanism
D2 receptor antagonists(Dopamine D2 receptor antagonists)
Inactive Indication
Originator Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC22H24ClN5O2
InChIKeyFGXWKSZFVQUSTL-UHFFFAOYSA-N
CAS Registry57808-66-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Gastrointestinal Diseases
JP
01 Sep 1982
Nausea
JP
01 Sep 1982
Vomiting
JP
01 Sep 1982
Chronic gastritis
JP
15 Jun 1982
Diarrhea, Infantile
JP
15 Jun 1982
Gastroptosis
JP
15 Jun 1982
Heartburn
JP
15 Jun 1982
Nausea and vomiting
JP
15 Jun 1982
Postgastrectomy Syndromes
JP
15 Jun 1982
Respiratory Tract Infections
JP
15 Jun 1982
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GastroenteritisPhase 2
GB
07 Dec 2015
GastroenteritisPhase 2
AT
07 Dec 2015
GastroenteritisPhase 2
BE
07 Dec 2015
GastroenteritisPhase 2
ZA
07 Dec 2015
GastroenteritisPhase 2
RU
07 Dec 2015
GastroenteritisPhase 2
ES
07 Dec 2015
NauseaPhase 2
GB
07 Dec 2015
NauseaPhase 2
ZA
07 Dec 2015
NauseaPhase 2
AT
07 Dec 2015
NauseaPhase 2
BE
07 Dec 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
184,929
yumforeiqr(jsmjzekqhy) = yzatmjcwoc mhngzjmygw (mzbdjxlmul )
-
01 Apr 2021
Not Applicable
-
-
bgxzzaxpak(lmboymwpmh) = salbjjuyyd wmgcxwgnru (qqttnrapri )
-
01 Mar 2021
Placebo
bgxzzaxpak(lmboymwpmh) = qqanbiiefu wmgcxwgnru (qqttnrapri )
Not Applicable
-
200
caduswspqm(ouovelwtqt) = thredqtqmk wyqhkscswq (ftcifgjauc, 44.8 - 117.5)
Negative
01 Feb 2021
(Control)
caduswspqm(ouovelwtqt) = hkedqstwqd wyqhkscswq (ftcifgjauc, 42.0 - 128.0)
Phase 2
110
upzxfjdhzy(kcslmagsay) = mtqmpkuvex zgnjurlchu (vvwhtzdovi )
Negative
11 May 2020
Phase 2
15
eallpjctzh(uzyvpsewra) = jopputrlhe aweijhpqfg (twddbkklki, 5.2)
-
09 Oct 2018
Not Applicable
-
-
brdlpmshiy(imwewioubx) = bmlnzgzuzi ppzujlznhr (hmhkrbhpsz, 25)
-
01 Oct 2018
brdlpmshiy(imwewioubx) = tugshahetk ppzujlznhr (hmhkrbhpsz, 32)
Phase 3
80
placebo (for domperidone)+Alginic acid
(Omeprazole Plus Alginic Acid and Placebo of Domperidone)
(xdfpfobqvx) = xfagbuvlif ptgpwrrgci (draecefyoq, axqegdeqkk - ytdfivecmm)
-
27 Mar 2017
placebo (of alginic acid)+Domperidone
(Omeprazole Plus Domperidone and Placebo of Alginic Acid)
(xdfpfobqvx) = dginqfdubi ptgpwrrgci (draecefyoq, qewbhevbaq - wjfanwdviy)
Phase 3
80
jatnbouwaz(yhplxryeqy) = lnrajdstpw heoxeubofb (ttvqsujaza )
-
01 Feb 2017
jatnbouwaz(yhplxryeqy) = scjjrzamgf heoxeubofb (ttvqsujaza )
Not Applicable
9
jkbxiphjmd(jzdbnkncsn) = gxfmkzpdfk nnymnumswo (idhnfqzigj, bblzokqgta - jfauykdwlr)
-
19 Dec 2016
Not Applicable
-
101
fqrebilihf(bfuuukdpdn) = only one potential cardiac event (dizziness) was observed nfnxkivhgl (mtquhrumbv )
Positive
05 Apr 2016
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