The objective of the paper is to establish the high performance liquid chromatog. anal. method of citalopram hydrobromide. The high performance liquid chromatog. separation and UV detector and use the external standard peak area method for quantification. The chromatog. column is YMC Basic B-02-5 (150 mm × 4.6 mm, 5 μm), the mobile phase is the mixed solution of acetonitrile and acetate buffer (pH 4.6, 20:80) (pH 5.0 ± 0.1) and the detection wavelength is 239 nm. The results showed that the range of 31.30-94.01 mg/L-1, the linear relationship is good, the mean recovery rate is 100.7% and RSD is 0.6%. The tested sample solution becomes stable after being kept under the room temperature for 6 days. It was concluded that the method is easy and accurate, which can be used to determine the active ingredients in citalopram hydrobromide.